Clinical trials: Lung Cancer Screening, open to volunteers
Liquid Biopsy for Early Screening of Lung Cancer
A Prospective Interventional Study on Early Screening for Lung Cancer Using Liquid Biopsy
This project aims to establish the MERCURY pilot screening program as part of the "Love Lung Project," employing a novel concept of lung cancer screening with the assistance of low-dose computer tomography (LDCT).
- Trial name
- NCT06422637
- Testing
- Liquid Biopsy Early Screening
- Where
- China
- Volunteers
- 5,944 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer
Cutting-edge IMAGING Technologies to Improve the SAFEty and the Sustainability of LUNG Cancer Screening and the Accuracy of Non-invasive Lung Nodules Characterization
Low-dose computed tomography (LDCT) is used in individuals at high risk of developing lung cancer (smokers over 50 years of age), as it allows for the identification of pulmonary nodules, which, in a small percentage of cases…
- Trial name
- NCT06963515
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Lung Cancer, Lung Neoplasms
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening.
- Conditions
- Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening
- Trial name
- NCT07358715
- Testing
- Liquid Biopsy (SPOT-MAS Assay), Exosome-Based Liquid Biopsy Assay, Low-Dose CT Thorax (LDCT)
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Lung Cancer Screening
Community-Based Engagement to Improve Lung Cancer Screening and Outcomes: The "Our Lungs Our Health" Study
The main goal of this pilot study is to understand the impact of a mobile lung cancer screening clinics in individuals from neighborhoods and communities with less access to resources in Boston, Massachusetts who are at high risk…
- Trial name
- NCT06909981
- Testing
- Low-Dose Computed Tomography Scan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lung Cancer
China Lung Cancer Screening (CLUS) Study Version 3.0
CLUS version 1.0, had proven that LDCT led to a 74.1% increase in detecting early-stage lung cancer compare to usual care (NCT02898441).
- Trial name
- NCT05494021
- Testing
- Whole-process management software, LDCT detection
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Health Screening
Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT
The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation.
- Conditions
- Lung Cancer, Health Screening, Early Cancer Detection, Deep Learning
- Trial name
- NCT06910956
- Testing
- CXR-LC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Increasing Equity in Lung Cancer Screening
The overall objective of this mixed methods study is to: 1) Refine the Emergency Department Lung Cancer Screening (ED-LCS) intervention using qualitative interviews among key stakeholders; 2) pilot test the ED-LCS intervention…
- Trial name
- LUCARE (NCT06360822)
- Testing
- ED-LCS
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Indiana University
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Lung Cancer
Association Between Screening Behaviors and Lung Cancer Spectrum
The goal of this observational study is to describe the clinical epidemiological characteristics and disease spectrum distribution of newly diagnosed primary lung cancer patients in a real-world setting.
- Trial name
- NCT07626177
- Where
- China
- Volunteers
- 5,390 people
- Sponsor
- Fudan University
Lung Cancer
Adaptation and Pilot Testing of a Lung Cancer Screening Decision Aid for Patients From a Safety-Net Healthcare System
The goal of the study is to adapt and test a participant decision aid about lung cancer screening for use with patients in theHarris Health System (HHS).
- Trial name
- NCT07382557
- Testing
- Surveys, Focus groups, Cognitive Interviews
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Lung Carcinoma
Evaluating the Impact of Centralized Interventions on Lung Cancer Screening Adherence in Community Settings, ACCELL Trial
This clinical trial tests the impact of lung cancer screening care coordination interventions implemented at the system-level on lung cancer screening adherence in community settings.
- Trial name
- NCT06324110
- Testing
- Electronic Health Record Review, Interview, Patient Navigation
- Where
- United States
- Volunteers
- 6,772 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Lung Cancer, Cancer of the Lung
Evaluating the Implementation and Effectiveness of the Pink and Pearl Campaign on Lung Cancer Screening at Christian Hospital
Inspired by the ongoing Pink \& Pearl Campaign, the breast radiology service of Christian Hospital in north St. Louis County will partner with Siteman Cancer Center to pilot this campaign in its mammography clinics in order to…
- Trial name
- NCT07146568
- Testing
- Pink and Pearl Campaign
- Where
- United States
- Volunteers
- 5,515 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infection, Tobacco-Related Carcinoma
Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study
This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking.
- Trial name
- NCT04949464
- Testing
- Computed Tomography, Smoking Cessation Intervention
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- AIDS Malignancy Consortium
Chronic Obstructive Pulmonary Disease (COPD)
Temple Health Chest Initiative (THCI 2.0)
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare…
- Trial name
- NCT06933758
- Testing
- Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Temple University
Lung Cancer
Research on Early Screening and Diagnosis of Pulmonary Nodules Based on Novel Non-invasive Technologies.
This is a prospective observational study designed to address the clinical challenge posed by the high false-positive rate associated with CT imaging in early lung cancer screening.
- Trial name
- NCT07370077
- Testing
- Employing multi-omics diagnostic approaches to enhance diagnostic efficacy
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Chen KeZhong
Lung Cancer, Lung Cancer Screening
Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Lung Cancer
The purpose of this research study is to test a new process for diagnosing lung cancer by examining changes to your DNA that can be detected from a blood test.
- Conditions
- Lung Cancer, Lung Cancer Screening, Healthy Volunteers (HV), Unhealthy Volunteers
- Trial name
- NCT07008664
- Testing
- Epigenetic Signature Assay
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lung Cancer (Diagnosis), Smoking Cessation
Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers
Lung cancer is common and serious, but when detected early, the chances of recovery are significantly better. Tobacco use is the leading cause.
- Conditions
- Lung Cancer (Diagnosis), Smoking Cessation, Lung Neoplasm
- Trial name
- NCT07860359
- Testing
- Image-Based Counseling, Smoking Cessation Coaching, Low-Dose Chest Computed Tomography (LDCT)
- Where
- Switzerland
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Hôpital Fribourgeois
Lung Disease, NSCLC (Non-small Cell Lung Cancer)
Cognitive Screening in Lung Cancer Patients
This study aims to investigate the occurrence of cancer and adjuvant therapy-related cognitive impairment in patients with both NSCLC and SCLC.
- Conditions
- Lung Disease, NSCLC (Non-small Cell Lung Cancer), SCLC
- Trial name
- NCT06727370
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- European Institute of Oncology
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
Melanoma, Gastrointestinal Cancer
Harvesting Cells for Experimental Cancer Treatments
Background: The NCI Surgery Branch has developed experimental therapies that involve taking white blood cells from patients' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells…
- Conditions
- Melanoma, Gastrointestinal Cancer, Metastatic Cancer, Breast Cancer
- Trial name
- NCT00068003
- Testing
- Anti-CD19 CAR PBL
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)