Clinical trials: Lung Disease
AI (Artificial Intelligence), Mammary Cancer
Experiment on the Use of Innovative Computer Vision Technologies for Analysis of Medical Images in the Moscow Healthcare System
It is planned to integrate various services based on computer vision technologies for analysis of the certain type of x-ray study into Moscow Unified Radiological Information Service (hereinafter referred to as URIS).
- Conditions
- AI (Artificial Intelligence), Mammary Cancer, Lung Cancer, X-Rays; Lesion
- Trial name
- NCT04489992
- Where
- Russia
- Volunteers
- 133,000 people, healthy volunteers welcome
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Endocrine/Neuroendocrine, Non-Small Cell Lung Cancer
Non-Viral TCR Gene Therapy
Background: A person s white blood cells can be modified in a lab to recognize certain changes in their tumor. Many of these cells are collected from the person, modified, then given back to the person.
- Conditions
- Endocrine/Neuroendocrine, Non-Small Cell Lung Cancer, Breast Cancer, Gastrointestinal/Genitourinary Cancers
- Trial name
- NCT04102436
- Testing
- Fludarabine, Cyclophosphamide, Aldesleukin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer
Studying Patterns, Causes, and Control of Disease in Patients With Lung Cancer in the North Trent (England) Region
RATIONALE: Gathering information about genetic and environmental factors from patients with lung cancer and their partners and first-degree relatives may help doctors learn more about the disease.
- Trial name
- NCT00693836
- Testing
- genetic linkage analysis, loss of heterozygosity analysis, mutation analysis
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cancer Research Centre at Weston Park Hospital
Lung Diseases
Continuous Erector Spinae Plane Block or Thoracic Epidural Analgesia Following Video Assisted Thoracic Surgery
Video assisted thoracic surgery (VATS) has recently been evaluated as the standard surgical procedure for lung surgery. Although VATS is less painful than thoracotomy, patients may feel severe pain during the first hours at…
- Trial name
- NCT03960736
- Testing
- ESP block (Group A), TEA group (Group B)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Asthma
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin
Leukotrienes are potent inflammatory molecules produced mainly by mast cells, eosinophils, monocytes/macrophage and neutrophils in response to allergic or inflammatory stimuli.
- Trial name
- NCT01411111
- Testing
- Rosuvastatin 10 mg, GSK2190915 30mg, GSK2190915 100mg
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
SARS-CoV-2 Infection
Study to Evaluate the Efficacy of COVID19-0001-USR in Patients With Mild/or Moderate COVID-19 Infection in Outpatient
Determine the efficacy and safety of COVID19-0001-USR in the treatment of SARS-COV-2 infection in mild to moderate manifestations administered via nebulization/inhalation.
- Trial name
- COVID-19 (NCT04595136)
- Testing
- Drug COVID19-0001-USR, normal saline
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- United Medical Specialties
Covid19, SARS-CoV Infection
Prevalence and Outcome of SARS-CoV-2 Infection & COVID-19 in Transplant Recipients: The COVITRA Study
This project will provide novel data using a large cohort of more than 3000 transplanted patients. Risk and protective factors for SARS-CoV-2 infection and COVID-19 disease severity will be identified.
- Conditions
- Covid19, SARS-CoV Infection, Transplantation Infection
- Trial name
- COVITRA (NCT04579471)
- Testing
- SARS-CoV-2 IgG
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Interstitial Pneumopathy/Pneumopathy Interstitial Diffuse, Paediatric and Adult Patients
RaDiCo PID Cohort (RaDiCo-ILD Cohort in English)
The main objective is to describe the phenotypic features of the paediatric and adult patients with Idiopathic Interstitial Pneumopathy/Pneumopathy Interstitial Diffuse (IIP/PID), at diagnosis and during the follow-up.
- Trial name
- RaDiCo-PID (NCT04238871)
- Where
- 2 sites in France
- Volunteers
- 1,600 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Non-small Cell Lung Cancer
Concurrent Endostar, Paclitaxel/Carboplatin and Radiotherapy for Locally Advanced Non-small Cell Lung (RT0902)
Concomitant chemoradiotherapy is the standard treatment of locally advanced, non-resectable, non-small cell lung cancer (NSCLC). However, the optimal chemotherapy regimen is still controversial.
- Trial name
- NCT01158144
- Testing
- Endostar, Paclitaxel/Carboplatin
- Where
- 2 sites in China
- Volunteers
- 134 people
- Sponsor
- Zhejiang Cancer Hospital
COPD Exacerbation, Bronchiectasis With Acute Exacerbation
Multi-omics Studies of Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis
Chronic obstructive pulmonary disease (COPD) and bronchiectasis are common chronic respiratory diseases in China. COPD is characterized by irreversible lung function decline due to airway inflammation, emphysema and alveolar…
- Trial name
- NCT05738044
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Fat Metabolism in OSA and COPD
Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by an obstruction of the upper airways. The obstruction results in periods of intermittent hypoxia and re-oxygenation, which lead to increased…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Obesity
- Trial name
- NCT02157844
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Bronchopulmonary Dysplasia, Encephalomalacia
Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants
The purpose of this study is to determine whether treatment of very preterm infants at high-risk for lung and brain injury with low dose hydrocortisone results in improved pulmonary and neurologic outcomes.
- Conditions
- Bronchopulmonary Dysplasia, Encephalomalacia, Premature Birth
- Trial name
- NCT00167544
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Nationwide Children's Hospital
Ivermectin, Hydroxychloroquine
A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh
COVID19 is a worldwide pandemic. Hence SARS-CoV-2 is a novel virus; there is no specific medication against it. Like other countries of the world, Bangladesh is also struggling in the case of treatment of this disease.
- Conditions
- Ivermectin, Hydroxychloroquine, COVID19
- Trial name
- NCT04434144
- Testing
- Ivermectin + Doxycycline, Hydroxychloroquine + Azithromycin
- Where
- Bangladesh
- Volunteers
- 116 people
- Sponsor
- Upazila Health & Family Planning Officer's (UHFPO) Office, Chakoria, Cox's Bazar
Premature Infants, Very Premature Infants
Anakinra Pilot 2 - A Study to Optimise Dose and Route of Administration of Anakinra in Preterm Infants
A phase 2 randomised, three-arm, parallel-group, dose-ranging trial to determine safety, efficacy and optimal dosing of intravenous anakinra in premature neonates, with subcutaneous pharmacokinetic sub-study.
- Conditions
- Premature Infants, Very Premature Infants, Inflammation
- Trial name
- AP2 (NCT07254000)
- Testing
- Anakinra (Kineret®)
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 24 people
- Sponsor
- Monash Medical Centre
Intercostal Nerve Block, Pulmonary Ventilation
EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade
This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery.
- Conditions
- Intercostal Nerve Block, Pulmonary Ventilation, Anesthesia, Local, Breast Neoplasms
- Trial name
- EIT (NCT07079436)
- Testing
- 0.25% ropivacaine, 0.375% Ropivacaine, 0.5% Ropivacaine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Fudan University
Chronic Cavitary Pulmonary Aspergillosis
Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis
The purpose of this study is to determine whether there itraconazole is effective in the treatment of chronic cavitary pulmonary aspergillosis
- Trial name
- ITRACONASP (NCT01259336)
- Testing
- Itraconazole, treatment in cavitary pulmonary aspergillosis
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Asthma
Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents
This is a multi-center, double-blind, placebo-controlled, randomized trial of dupilumab adjunctive therapy for prevention of asthma exacerbations in urban children and adolescents with T2-high exacerbation-prone asthma.
- Trial name
- PANDA (NCT05347771)
- Testing
- Dupilumab
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Obstructive Pulmonary Disease
A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.
This is a phase II clinical trial to evaluate the efficacy and safety of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05987371
- Testing
- TQC3721 suspension for inhalation, Salbutamol sulfate inhalation aerosol
- Where
- 11 sites in China
- Volunteers
- 75 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Cancer, Advanced Malignancies
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
The primary purpose of this study is to assess the safety and tolerability of AB598 in participants with advanced malignancies.
- Conditions
- Advanced Cancer, Advanced Malignancies, Bladder Cancer, Cervical Cancer
- Trial name
- ARC-25 (NCT05891171)
- Testing
- AB598, Zimberelimab, Fluorouracil
- Where
- 14 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Arcus Biosciences, Inc.
Severe, Refractory Asthma, Airway Inflammation
A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma
Background: Individuals who have severe asthma that is not easily controlled by current treatments are in need of new treatments to prevent potentially life-threatening asthma attacks.
- Conditions
- Severe, Refractory Asthma, Airway Inflammation, Airflow Obstruction
- Trial name
- NCT00994175
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)