Clinical trials: Lung Disease Airways
COPD
Effects of Long Term Macrolide Antibiotic Therapy in Patients With COPD
The purpose of this study is to determine whether long term treatment with oral erythromycin is effective in the treatment of subjects with Chronic Obstructive Pulmonary Disease (COPD) by reducing the number of exacerbations and…
- Trial name
- NCT00147667
- Testing
- Erythromycin
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Royal Free and University College Medical School
Bronchial Asthma, Airway Disease
FeNO Detection in Asthma Diagnosis: A New Technology Approach
The detection of exhaled nitric oxide (FeNO) represents a non-invasive, safe, and rapid approach for assessing endogenous nitric oxide (NO) levels within the airway.
- Trial name
- NCT06852911
- Testing
- Chemiluminescent FeNO Analyzer, Electrochemical FeNO Analyzer
- Where
- 2 sites in China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Novlead Inc.
Cystic Fibrosis
A Short-term Comparative Study of Aerosure for Airway Clearance in Patients With Cystic Fibrosis
This is a double-blind randomised controlled crossover study to investigate whether high frequency airflow oscillation (HFAO), delivered using Aerosure, improves sputum clearance in patients admitted to hospital with infective…
- Trial name
- NCT01923753
- Testing
- Aerosure at 15 Hz, Aerosure at 25 Hz
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Actegy Ltd.
Asthma
Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Bronchial asthma is a common chronic respiratory disease. Patients usually manifest variable symptoms (such as short of breath, chest tightness, cough, etc.) and variable airflow limitation and often associated with airway…
- Trial name
- NCT02574975
- Testing
- methacholine, adenosine monophosphate, leukotriene D4
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on exercise performance at altitude in patients with COPD.
- Trial name
- NCT03177837
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 176 people
- Sponsor
- University of Zurich
Tumor Motion, "Continuous Positive Airway Pressure"
Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy
This is a clinical study on patients to compare the effects of CPAP on lung volume diaphragm motion, heart position and tumor motion compared to free breathing.
- Conditions
- Tumor Motion, "Continuous Positive Airway Pressure", Lung Cancer, Breast Cancer
- Trial name
- NCT02324530
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Chronic Airway Disease and Multimorbidity Cohort
Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Bronchiectasis
- Trial name
- CAM Cohort (NCT06798077)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- China-Japan Friendship Hospital
Asthma
A Blinded Study To Examine The Ability Of PF-610,355 To Open The Airways In Asthmatic Patients.
A study to determine the ability of different doses of PF-610,355 to open the airways in asthmatic patients by comparison with placebo and a marketed drug that also opens the airways in asthmatic patients.
- Trial name
- NCT00468975
- Testing
- PF-610,355, Salmeterol
- Where
- 6 sites in Germany, Sweden and 1 more
- Volunteers
- 42 people
- Sponsor
- Pfizer
Asthma
Mometasone and Markers of Airway Inflammation
A post-marketing study to look at the effects of Asmanex on markers of airway inflammation.
- Trial name
- NCT00711165
- Testing
- Mometasone Furoate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Creighton University
Respiratory Distress Syndrome, Newborn
Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome
In this study, newborn babies with respiratory distress syndrome (RDS), receiving oxygen via nasal continuous airway pressure (CPAP) modalities, and needing surfactant treatment will be randomized to standard delivery of…
- Trial name
- NCT02164734
- Testing
- Endotracheal intubation, Laryngeal mask airway, remifentanil
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Albany Medical College
Smoking, Airway Obstruction
Effect of the Salbutamol on Mechanical Properties of Respiratory System
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
- Trial name
- NCT01521572
- Testing
- Salbutamol sulphate
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Pulmonary Diseases
Airways Dysfunction Following WTC Dust Exposure
In the weeks following the terrorist attacks of September 11, 2001, many patients presented to their physicians with complaints related to exposure to the debris.
- Trial name
- NCT00395330
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Protocol Early Used in Acute Respiratory Distress Syndrome
The aim of this study is to assess the effects and safety of the early application of BILEVEL-APRV protocol and conventional ventilation strategy that used low tidal volume and adequate PEEP level in ARDS patients .
- Trial name
- NCT02639364
- Testing
- Nellcor Puritan Bennett 840 ventilator system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Chronic Obstructive Pulmonary Disease, Lung Disease Causing Persistent Narrowing of the Airways
AZD2115 Single Ascending Dose Study
AZD2115 Single Ascending Dose Study
- Trial name
- NCT01283984
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
Effects of Montelukast in Children With Asthma
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (FENO) concentrations in children with asthma, but the effect of LTRA withdrawal on FENO and lung function is unknown.
- Trial name
- NCT00675285
- Testing
- montelukast sodium
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Catholic University of the Sacred Heart
Pulmonary Disease, Chronic Obstructive
Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD
The goal of this clinical trial was to compare the action of long-acting ß2-agonists (LABA-olodaterol) and muscarinic antagonists (LAMA-tiotropium) on tissue oxygenation in COPD considering their impact on proximal and peripheral…
- Trial name
- NCT05927155
- Testing
- LABA, LAMA
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Cystic Fibrosis
Comparison of Airway Clearance Efficacy of Two High Frequency Chest Wall Oscillation (HFCWO) Devices in Cystic Fibrosis
Patients with cystic fibrosis (CF) must perform daily bronchial drainage therapy (BD) to keep their airways clear of secretions.
- Trial name
- NCT00308958
- Testing
- High frequency chest wall oscillator
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Airway Remodeling, Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
This randomized, open-label, three-arm clinical trial evaluated the effects of tiotropium on airway remodeling in patients with GOLD stage 1 COPD using endobronchial optical coherence tomography (EB-OCT).
- Trial name
- NCT03842839
- Testing
- Tiotropium Inhalation Powder [Spiriva] 0.018mg, Salbutamol sulphate aerosol (Ventolin) 0.1mg
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Transient Tachypnea of the Newborn
High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation
The primary objective is to determine whether High Flow Nasal Cannula (HFNC) is a superior respiratory modality for neonates ≥36 weeks with transient tachypnea of the newborn (TTN) when compared to the standard of care modality…
- Trial name
- NCT01270581
- Testing
- High Flow Nasal Cannula, Bubble Nasal CPAP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bronchopulmonary Dysplasia (BPD)
Continued Pressure for Alveolar Protection (CPAP Trial)
The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at…
- Trial name
- CPAP (NCT07417111)
- Testing
- CPAP, Nasal Cannula
- Where
- 15 sites in United States
- Volunteers
- 860 people
- Sponsor
- NICHD Neonatal Research Network
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