Clinical trials: Lung Disease Airways
Lung Disease
The Effectiveness of BreatheMAX Breathing Device on Secretion Clearance
The purpose of this study is to determined effects of BreatheMAX on secretion clearance.
- Trial name
- ESMOSC (NCT01090804)
- Testing
- BreatheMAX breathing device
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Khon Kaen University
Asthma
Assessing the Expression and the Activity of Rac1 Protein in the Airway Smooth Muscle of Asthmatic Patient
Asthma is a chronic inflammatory respiratory disease affecting 6 to 7% of the French adult population and responsible of 1000 deaths in France every year.
- Trial name
- NaRacAS (NCT03325088)
- Testing
- Bronchial endoscopy, Bronchial biopsies, Bronchial alveolar enema
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Nantes University Hospital
Asthma, Chest Syndrome
Clinical Characteristics and Treatment of Chest Tightness Variant Asthma
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Clinical Anxiety, Clinical Depression
- Trial name
- NCT04322422
- Testing
- Inhaled corticosteriod/long-acting beta-agonist plus Montelukast, Inhaled corticosteriod/long-acting beta-agonist only
- Where
- 33 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Obstructive Pulmonary Disease, Bronchiectasis
Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD
The purpose of this study is to evaluate the safety and efficacy of four times daily Positive Expiratory Pressure (oPEP) (Aerobika ®) maneuvers over three weeks in individuals with bronchiectasis and chronic obstructive pulmonary…
- Trial name
- NCT02282202
- Testing
- Oscillating Positive Expiratory Pressure (Aerobika ®)
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Western University, Canada
Asthma
Study of the Mechanisms of Asthma
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.
- Trial name
- MAST (NCT00595153)
- Testing
- Pulmicort
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asthma, COPD
A Comparison of Two Nebulisers for Sputum Induction
Sputum induction is considered a relatively non-invasive, reliable procedure, which can be utilised to characterise the inflammatory profile of the airways. However, the procedure can be slightly uncomfortable for patients.
- Trial name
- FLAME (NCT04182009)
- Testing
- Omron NE-U17 Ultrasonic nebuliser, Akita Jet Inhalation System
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Nottingham
Pulmonary Aspiration of Gastric Contents
Videolaryngoscopy Compared to Direct Laryngoscopy
Videolaryngoscope (Macintosh-type blade) compared with direct laryngoscopy for rapid sequence intubation in the operating room
- Trial name
- LARA (NCT04794764)
- Testing
- McGrath Mac, Macintosh Laryngoscope
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Copd
FEV1/FEV6 and FEV6 as an Alternative for FEV1/FVC and FVC in Bolivian Subjects
Comparison of FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FCV in the detection of airway obstruction in a Bolivian population
- Trial name
- NCT03534557
- Testing
- FEV6 spirometry
- Where
- Bolivia
- Volunteers
- 70 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Respiratory Distress Syndrome
High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome
To compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated…
- Trial name
- NCT02587832
- Testing
- HHHFNC, NCPAP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidra Medicine
Cystic Fibrosis
Macrolide Antibiotic Therapy for Patients With Cystic Fibrosis
The purpose of this study is to evaluate whether Biaxin (clarithromycin) improves sputum abnormalities, lung function, and overall feeling of well-being in people with cystic fibrosis (CF).
- Trial name
- NCT00205634
- Testing
- Biaxin ( clarithromycin)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University
COPD
Evaluation of Airway Gene Expression in COPD and Controlled Populations
To explore potential proteins that may be used to develop novel therapies for COPD. This will be accomplished by acquiring material from the lower respiratory tract via endobronchial brushings.
- Trial name
- NCT00571792
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
Asthma
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma
The purpose of this study is to determine whether an inhaled corticosteroid (fluticasone) alters the expression of any gene expressed in the lining of the airways of asthmatics.
- Trial name
- NCT00187499
- Testing
- Inhaled fluticasone 500 ug BID for 8 weeks
- Where
- United States
- Sponsor
- University of California, San Francisco
Reactive Airways Disease (RAD)
Study of Levalbuterol and Racemic Albuterol in Pediatric Subjects With Reactive Airways Disease (RAD)
The purpose of this study is to compare the efficacy of two dose levels of levalbuterol compared with one dose level of racemic albuterol in pediatric subjects aged birth to 48 months old.
- Trial name
- NCT00685126
- Testing
- Levalbuterol HCl Inhalation Solution, Albuterol HCl Inhalation Solution
- Where
- 34 sites in United States, Canada
- Volunteers
- 117 people
- Sponsor
- Sumitomo Pharma America, Inc.
COPD
What Influences Patient Outcome in Obstructive Airway Disease?
The aim of this observational study is to utilise the established record linkage data available in Tayside to investigate hospital admissions, exacerbations and mortality in COPD.
- Trial name
- NCT01221480
- Volunteers
- 5,977 people
- Sponsor
- University of Dundee
Asthma
Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies.
Comparison of two asthma treatments by lung function measures.
- Trial name
- NCT00370591
- Testing
- Salmeterol/fluticasone propionate and fluticasone propionate
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- GlaxoSmithKline
Bronchiectasis Adult
Characterization of Airway Mucus in Bronchiectasis Patients and Healthy Controls
Analysis of mucus, mucin and DNA concentration, MUC5B/5AC ratio, rheology, osmotic pressure, cohesion and nucleotides in sputum on 30 individual samples of good quality in healthy individuals and those with bronchiectasis.
- Trial name
- NCT03125174
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Previous investigations and anecdotal experience have shown safety and utility of Noninvasive Positive Pressure Ventilation/Bilevel Positive Airway Pressure (NIPPV/BiPAP) for the treatment of asthma in children.
- Trial name
- RCT BiPAP (NCT01497691)
- Testing
- NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants
The primary aim of this study is to quantify and compare changes in lung volumes (as measured by functional residual capacity) in premature infants stable on continuous positive airway pressure (CPAP), and then randomized to two…
- Trial name
- NCT02249143
- Testing
- CPAP and room air
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
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