Clinical trials: Lung Disease Chronic
Pulmonary Disease, Chronic Obstructive
Drug Interaction Study to Investigate Co-administration of GW642444M With Ketoconazole
This will be a single-centre, randomised, double blind, placebo controlled, two-way crossover study in healthy male and female subjects. There will be two treatment periods each consisting of 7 days.
- Trial name
- NCT00866515
- Testing
- Ketoconazole + GW642444M
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, ILD
SWEEP: Shuttle Walking Test for Exercise Evaluation in Pulmonary Resection
This is a prospective observational study that evaluates whether the Shuttle Walking Test (SWT) can predict postoperative symptoms, particularly dyspnea, in patients with chronic respiratory diseases undergoing lung resection.
- Conditions
- COPD, ILD, Bronchiectasis, Lung Cancer NOS
- Trial name
- SWEEP (NCT07102589)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Chronic Obstructive Pulmonary Disease, Muscle Weakness Conditions
Effects of Inspiratory Muscle Training on Breathing Pattern in Patients With Chronic Obstructive Pulmonary Disease
The improvement in inspiratory muscle function might result in beneficial changes in breathing pattern during whole body exercise.
- Trial name
- NCT02186340
- Testing
- Inspiratory muscle training
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- KU Leuven
COPD, Pulmonary Rehabilitation
Assessment of Utility of accelerateIQ in the Care of Patients Participating in a Pulmonary Rehabilitation Program
The proposed study seeks to assess the performance of continuous biosensor data and machine learning analytics in assessment of health patient status in a pulmonary rehabilitation program.
- Trial name
- GASSP (NCT03879291)
- Testing
- pinpointIQ
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Karen Larimer
COPD
Exercise Training and Inflammatory Mediators in COPD
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1].
- Trial name
- NCT03853174
- Testing
- Endurance Training ET, Resistance Training RT
- Where
- Tunisia
- Volunteers
- 28 people
- Sponsor
- Faculty of Medicine, Sousse
Chronic Inflammatory Pulmonary Diseases
Cohort for Research and Innovation in Chronic Inflammatory Respiratory Diseases
Chronic inflammatory pulmonary diseases including chronic obstructive pulmonary disease (COPD), interstitial lung diseases (ILD), bronchiectasis, and cystic fibrosis (CF) are characterized by lung inflammation and remodelling.
- Trial name
- RINNOPARI (NCT02924818)
- Testing
- Clinical assessment, questionnaires, pulmonary function test
- Where
- France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Chronic Obstructive Pulmonary Disease (COPD)
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of KIT2014 in Patients With Moderate to Severe COPD
Study investigating the safety, tolerability, pharmacokinetics and early efficacy with KIT2014 over 7 days of treatment in moderate to severe chronic obstructive pulmonary disease patients.
- Trial name
- NCT07668518
- Testing
- KIT2014
- Where
- 3 sites in Australia
- Volunteers
- 36 people
- Sponsor
- Kither Biotech Srl
Asthma Chronic, Asthma in Children
Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With Asthma
This study evaluated the efficacy of doxophylline as a steroid sparing treatment in Mexican children with asthma treated with medium ir high doses of inhaled corticosteroids (ICS).
- Trial name
- NCT03879590
- Testing
- Doxophylline, Budesonide
- Volunteers
- 60 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on cognition in lowlanders with chronic obstructive pulmonary disease travelling from 760 m to 3200 m.
- Trial name
- NCT03165890
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 78 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
The London COPD Exacerbation Cohort
The London COPD exacerbation (EXCEL) cohort builds on an established cohort started in 1995 and designed to study COPD exacerbations and their impact on health-status and disease progression.
- Trial name
- EXCEL_Cohort (NCT02755974)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Post-COVID19 Condition
Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study
PAX is a prospective, randomized (1:1), double-blind, placebo-controlled study, that have as a objective to evaluate the safety and tolerability of plasma exchange (PE) in patients with Post Acute Covid-19 Syndrome (PCC)…
- Trial name
- NCT05445674
- Testing
- Plasma Exchange Procedure
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Chronic Obstructive Pulmonary Disease Severe, Interstitial Lung Disease
Effect of HIgh-flow Therapy in Long-term Oxygen Therapy
This is a registry-based, randomized, controlled clinical trial of the effect of added high-flow oxygen therapy (using the device Lumis HFT) during one year in people with long-term oxygen therapy (LTOT) for chronic obstructive…
- Conditions
- Chronic Obstructive Pulmonary Disease Severe, Interstitial Lung Disease, Chronic Respiratory Failure With Hypoxia
- Trial name
- HILOT (NCT06247397)
- Testing
- Added high-flow oxygen therapy, Standard care
- Where
- 2 sites in Sweden
- Volunteers
- 310 people
- Sponsor
- Skane University Hospital
Post COVID-19 Condition, Long COVID Syndrome
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of…
- Conditions
- Post COVID-19 Condition, Long COVID Syndrome, Persistent COVID-19, Persistent COVID Condition
- Trial name
- THALASSA (NCT06766825)
- Testing
- Plitidepsin 1.5 mg/day
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Bronchodilators in Mild Chronic Obstructive Pulmonary Disease (COPD)
In people with mild COPD, the ability to exhale air from the lungs is partly limited because of narrowing and collapse of the airways.
- Trial name
- NCT00202176
- Testing
- Ipratropium Bromide
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Queen's University
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy of L-menthol on Breathlessness in Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- Ment-COPD (NCT05888597)
- Testing
- L-menthol
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Pulmonary Embolism, Pulmonary Hypertension
Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus Anticoagulation Alone
Clinical presentation of acute pulmonary embolism (PE) is complex and varied and not uncommonly involves respiratory failure with dyspnea or hypoxia.
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- VQPE (NCT05133713)
- Testing
- Catheter directed therapy, Systemic anticoagulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Cystitis, Interstitial, Painful Bladder Syndrome
- Trial name
- NCT04275297
- Testing
- Psychosocial Treatment, Attention Control
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University Medical Center
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Emphysema
Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD
COPD is a significant health problem worldwide. It affects more than 10% of patients over the age of 40. According to the World Health Organization, it is the third most common cause of death among adults in the world, and the…
- Conditions
- COPD, Emphysema, Chronic Bronchitis, Smoking
- Trial name
- NCT06826560
- Where
- Poland
- Volunteers
- 92 people
- Sponsor
- Medical University of Warsaw
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