Clinical trials: Lung Function Changes
Complication,Postoperative, Lung Cancer
Relationship Between Hand Dynamometer Measurements, PFT, and mFI With Postoperative Outcomes
The study will take place at SBÜ Ankara Atatürk Sanatorium Training and Research Hospital and will include 100 patients over the age of 40 who are scheduled for lung malignancy surgery after 01 April 2024.
- Trial name
- NCT06338007
- Testing
- Hand Dynamometer, Pulmonary Function Test, Modified Frailty Index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Myotonic Dystrophy
Postural Spirometry Changes in Ambulatory Myotonic Dystrophy Patients
Myotonic dystrophy Type 1 (MD1, Steinert's disease), an autosomal dominant multisystem disease, is of the most common muscular dystrophies in adults, with a European prevalence of 3-15/100 000.
- Trial name
- NCT01242007
- Testing
- Supine spirometry
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University of Nancy
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
COPD, COPD Exacerbation
A Retrospective rEal-life daTa Study to Assess the exaceRbations and Lung functIon in Chronic Obstructive Pulmonary Disease ( COPD ) patiEnts receiVing Fluticasone/Salmeterol Comparing to Those Εscalating in Open-triple Fluticasone/Salmeterol, Long Acting Muscarinic Antagonist (LAMA) Combination
Inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) combination is commonly prescribed to treat COPD; we will perform a retrospective analysis on the effect of adding a long-acting muscarinic receptor antagonist (LAMA) to…
- Trial name
- RETRIEVE (NCT03858348)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Rheumatoid Arthritis, Inflammatory Myositis
Rituximab-induced Pulmonary Function Changes
Measuring lung function (FVC, FEV1, DLCO) before, during and after treatment with rituximab in patients with rheumatoid arthritis or inflammatory myositis.
- Trial name
- NCT01632124
- Testing
- Lung function measurement
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Obesity
Postural Changes in Lung Volumes in Obesity
Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position.
- Trial name
- NCT02207192
- Testing
- Postural change in lung volumes: sitting to Supine
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Association pour la Formation du Personnel à la Medecine d'Urgence
Healthy
Hemodynamic and Respiratory Function in Healthy Pregnant Women
This study looks at hemodynamic and respiratory function in healthy pregnant women; it is a longitudinal study.
- Trial name
- NCT00199693
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Respiratory Function Tests, Long COVID
Late Respiratory Consequences of SARS-CoV-2 Pneumonia
The goal of this observational study is to learn about the respiratory system in post-COVID syndrome. The main question aims to answer: how the post-COVID syndrome alters the lung function Participants will be asked to perform…
- Trial name
- NCT05812196
- Testing
- Lung function test, COVID infection
- Where
- Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Szeged University
Cancer, Cachexia
Mitochondrial Respiratory Function in Mammalian Skeletal Muscle
The purpose of this study is to determine whether skeletal muscle mitochondrial function is altered in patients with head and neck cancer compared to healthy controls.
- Trial name
- NCT02650570
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Asthma
Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
As a non-selective bronchodilator, magnesium sulfate (MgSO4) is effective when administered intravenously in the treatment of the patients with acute severe asthma not responding to conventional therapy (oxygen, nebulized…
- Trial name
- NCT01856959
- Testing
- Magnesium Sulfate, magnesium sulfate & albuterol, Albuterol
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Metastatic Melanoma
Ipilimumab-induced Lung Toxicity: Observational Study
Serial spirometries and measurements of CO-diffusion capacity (DLCO) in patients with MM before and during treatment with ipilimumab are performed.
- Trial name
- Ipi-Lu-Tox (NCT02755233)
- Testing
- Pulmonary Function
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Evaluation With CT Scan of Possible Changes in Airways After Treatment With Daxas® in Severe Chronic Obstructive Pulmonary Disease Patients
In this study the possible changes in airway geometry and function induced by 6 month oral treatment with Daxas® (roflumilast) will be evaluated.
- Trial name
- NCT01480661
- Testing
- Roflumilast, Functional Respiratory Imaging
- Where
- 2 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- FLUIDDA nv
Cerebral Palsy
Change of Pulmonary Function After Incentive Spirometer Training in Children With Cerebral Palsy
This study was designed to examine the effect of incentive spirometry in pulmonary rehabilitation of children with cerebral palsy.
- Trial name
- NCT02406404
- Testing
- Incentive spirometer training
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Yonsei University
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Cystic Fibrosis, Lung Disease
Magnetic Resonance Imaging (MRI) for Early Diagnosis of Cystic Fibrosis (CF)
In patients with Cystic Fibrosis (CF) the clinical course of lung disease is crucial for individual prognosis and life expectancy.
- Trial name
- NCT00760071
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
NSCLC Stage IV
Cachexia in NSCLC Patients: Diagnosis, Characterization, Prognosis, Functional and Skeletal Muscle Implications
LUCAX01 is a cohort study with patients with advanced NSCLC in tobacco users. in this study, patients will be submitted to baseline physical tests, blood and biopsy sample collection, and the main objective is to study the…
- Trial name
- LUCAX01 (NCT03960034)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Small Cell Lung Cancer
Memory and MRI Changes With Hippocampus Avoidance Prophylactic Cranial Irradiation(HA-PCI) for Small Cell Lung Cancer(SCLC)
This is a prospective, randomized phase-II study observing the memory preservation and functional brain MRI changes with conformal avoidance of the hippocampal neural stem-cell compartment during prophylactic cranial irradiation…
- Trial name
- NCT02906384
- Testing
- hippocampus avoidance
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhejiang Cancer Hospital
Lung Cancer (Diagnosis), Patient-Reported Symptom Burden
Symptoms, Physical Function, and Recovery in Patients Receiving Lung Cancer Treatment Before Surgery
This study will examine how symptoms and physical abilities change during lung cancer treatment given before planned surgery, and how these changes relate to recovery after surgery.
- Conditions
- Lung Cancer (Diagnosis), Patient-Reported Symptom Burden, Physical Function
- Trial name
- NCT07853443
- Testing
- Longitudinal Assessment of Symptoms, Physical Function, and Postoperative Recovery
- Volunteers
- 360 people
- Sponsor
- Aerospace Center Hospital
Acute Lung Injury
Changes in Alveolar Macrophage Function During Acute Lung Injury
In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.
- Trial name
- NCT02693912
- Testing
- Bronchoscopy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco
Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms
The aim of the proposed trial in assessment of effects of Kalydeco™ treatment on sinonasal involvement in CF patients with at least one mutation of G551D receiving a new therapy with the CFTR potentiator.
- Trial name
- KPNSI (NCT02311140)
- Testing
- nasal lavage (routine diagnostic procedure in our centre), assessment of symptoms
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Jena