Clinical trials: Lung Hyperinflation
Pulmonary Disease, Chronic Obstructive
Effects of Tiotropium on Breathing Capacity and Exercise Limitation in Early Stages of Chronic Obstructive Pulmonary Disease
Optimal clinical management in early stages of COPD is not established. Tiotropium has been shown to improve exercise tolerance during (CWR) cycle ergometry with GOLD stage II to IV COPD, improvements in constant speed treadmill…
- Trial name
- NCT01072396
- Testing
- Tiotropium
- Where
- 15 sites in United States, Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Secondhand Smoke, Air Trapping
Secondhand Smoke Respiratory Health Study
Exposure to secondhand tobacco smoke (SHS) is associated with diverse health effects in nonsmokers. Flight attendants (FA) who worked on commercial aircraft before the ban on tobacco smoking (exposed FAs) had high, long-term…
- Conditions
- Secondhand Smoke, Air Trapping, Tobacco, Airflow Limitation
- Trial name
- NCT02797275
- Testing
- Albuterol
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, San Francisco
Mechanically Ventilated Patients, Lung Compliance
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.
- Conditions
- Mechanically Ventilated Patients, Lung Compliance, Airway Clearance Impairment
- Trial name
- NCT06791798
- Testing
- Ventilator Hyperinflation, Vibrocompression, Traditional Chest Physical Therapy Program
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Pulmonary Arterial Hypertension
Bronchodilator's Effects on Exertional Dyspnoea in Pulmonary Arterial Hypertension
Activity-related dyspnoea appears to be the earliest and the most frequent complaint for which patients with PAH seek medical attention.
- Trial name
- BD-HTAP (NCT02782052)
- Testing
- Nebulized ipratropium bromide, Nebulized combination ipratropium bromide with salbutamol
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infections, Respiratory, Ventilator Associated Pneumonia
Comparison Between Different Ventilator Hyperinflation Maneuvers
The hyperinflation ventilator was performed in different modalities and ventilatory adjustments, with total pressure of 40cmH2O.
- Trial name
- NCT03631342
- Testing
- VCV20, VCV40, PCV
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Chronic Obstructive Pulmonary Disease
The Effects of a Positive Expiratory Pressure (PEP) on Dyspnea and Dynamic Hyperinflation During Exercise in Chronic Obstructive Pulmonary Disease (COPD) Patients
From the relationship between pathophysiology of chronic obstructive pulmonary disease (COPD), dyspnea, and dynamic hyperinflation during ventilatory increasing, the investigators hypothesize that 1.
- Trial name
- NCT00741832
- Testing
- Conical Positive Expiratory Pressure Device (C-PEP), Control breathing
- Where
- Thailand
- Volunteers
- 11 people
- Sponsor
- Khon Kaen University
Obstructive Sleep Apnea
The Effect of CPAP on Lung Hyperinflation in Patients With OSA
Assessment of the lung hyperinflation by bodypletysmography in patients with obstructive sleep apnoea treated with continuous positive airway pressure therapy.
- Trial name
- NCT04084899
- Testing
- Continuous Positive Airway Pressure therapy
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Chronic Obstructive Pulmonary Disease
Pursed-lips Breathing and Dynamic Hyperinflation
Background: Dynamic hyperinflation (DH) is an important factor leading to dyspnea and consequent limitations in functional capacity of chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT02203058
- Testing
- Pursed-lips breathing, No pursed-lips breathing
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- University of the State of Santa Catarina
Pulmonary Disease, Chronic Obstructive
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients.
The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD.
- Trial name
- NCT01533935
- Testing
- Tiotropium + Olodaterol, Tiotropium, Olodaterol
- Where
- 33 sites in United States, Argentina and 6 more
- Volunteers
- 291 people
- Sponsor
- Boehringer Ingelheim
Dynamic Lung Hyperinflation, COPD Patients
Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients
Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles.
- Conditions
- Dynamic Lung Hyperinflation, COPD Patients, Activities of Daily Livin.
- Trial name
- Hyperinflation (NCT01475812)
- Testing
- Hyperinflation and ADL
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Federal University of São Paulo
Hypoxaemia During Surgery, Lung Hyperinflation
HFHO vs CPAP During Thoracic Surgery
A single institutional cross-over study design to compare between high flow humidified oxygen (HFHO) device versus conventional CPAP for non-ventilated lung during thoracic surgery.
- Trial name
- NCT03894072
- Testing
- CPAP, HFHO
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Mahidol University
Emphysema, Pulmonary, Emphysema or COPD
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe.
- Trial name
- CONVERT_II (NCT06035120)
- Testing
- AeriSeal System
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 200 people
- Sponsor
- Pulmonx Corporation
Air Trapping, Emphysema
Xenon MRI to Evaluate Changes to Lung Function Following Bronchoscopic Treatment of Air Trapping in Emphysema
The objective of this study is to provide a regional, mechanistic characterization of pulmonary ventilation changes following treatment with the Apreo BREATHE System, using hyperpolarized ¹²⁹Xe MRI, in BREATHE-3 participants.
- Conditions
- Air Trapping, Emphysema, Hyperinflation
- Trial name
- BREATHE-Xe (NCT07896902)
- Testing
- Hyperpolarized Xenon MRI, Apreo BREATHE Airway Scaffold
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Apreo Health, Inc.
Pulmonary Disease, Chronic Obstructive
Mechanisms of Dyspnea Relief During Exercise in COPD Patients Following Treatment With Tiotropium (Spiriva)
To explore the mechanisms of dyspnea relief during exercise in patients with COPD following treatment with tiotropium bromide (Spiriva)
- Trial name
- NCT00274027
- Testing
- tiotropium bromide
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Boehringer Ingelheim
Emphysema, COPD
Mind The Gap - Crossing Borders Study
Rationale: A big step forward and great opportunity to improve overall efficacy of bronchoscopic lung volume reductioen is to combine treatment modalities aiming to close the dependent collateral channels and then proceed with…
- Conditions
- Emphysema, COPD, Hyperinflation Lung
- Trial name
- NCT04256408
- Testing
- Bronchoscopic transparenchymal interlobar fissure closure using Aeriseal
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- University Medical Center Groningen
Pulmonary Disease, Chronic Obstructive
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients
The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD
- Trial name
- NCT01533922
- Testing
- Tiotropium, Olodaterol, tiotropium + olodaterol
- Where
- 44 sites in United States, Argentina and 8 more
- Volunteers
- 295 people
- Sponsor
- Boehringer Ingelheim
Emphysema
Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil
Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil (HEAT-LVRC) on Hyperinflation in Severe Emphysema
- Trial name
- HEAT-LVRC (NCT02835001)
- Testing
- Bronchoscopy, Lung Volume Reduction Coil (HEAT-LVRC)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Heart Diseases
The Use of Pulmonary Hyperinflation With the Mechanical Ventilator in Cardiac Patients
Mechanical ventilation (MV) is used to reduce work and reverse or prevent fatigue of the respiratory muscles, decrease oxygen consumption and maintain gas exchange.
- Trial name
- NCT04583371
- Testing
- MECHANICAL PULMONARY HYPERINFLUATION
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Asthma
Prevalence and Reversibility of Lung Hyperinflation in Asthma
The aim of this observational study is to evaluate the pulmonary hyperinflation and its immediate reversibility to a short acting beta2 agonist test in uncontrolled persistent asthmatic patients with dyspnea.
- Trial name
- Dist'air2 (NCT01573364)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Disease, Chronic Obstructive
Effect of Expiratory Positive Pressure on Dynamic Hyperinflation and Ability to Exercise With Upper Limbs in COPD
The study will evaluate the effect of positive airway expiratory pressure (EPAP) on patients with chronic obstructive pulmonary disease (COPD) during submaximal upper limb exercise.
- Trial name
- NCT03073564
- Testing
- Endurance test for upper limbs, Functional test
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital de Clinicas de Porto Alegre