Clinical trials: Lung Infection
Malaria, Pneumonia
Home Management of Malaria and Pneumonia
A well-implemented community-based program of early and appropriate treatment of fevers/malaria episodes and pneumonia,will improve child survival as measured by a reduction of the less than five mortality rate.
- Trial name
- HMM/P (NCT02151578)
- Testing
- home/community case management
- Where
- Burkina Faso
- Volunteers
- 11,500 people
- Sponsor
- World Health Organization
Rheumatoid Arthritis
Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders
The objective of this study was to evaluate the safety of Enbrel (etanercept) in rheumatoid arthritis (RA) subjects with greater than or equal to 1 documented comorbid disease (diabetes mellitus; chronic pulmonary disease…
- Trial name
- NCT00132418
- Testing
- Enbrel
- Volunteers
- 564 people
- Sponsor
- Amgen
Fever, Pneumonia
The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines
Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.
- Trial name
- NCT01089218
- Testing
- oral amoxicillin/clavulanate 1g (875/125mg), control
- Volunteers
- 241 people
- Sponsor
- Seoul National University Hospital
COVID-19
Immunogenicity，Safety and Cross - Immune Response With Mutant Strains of a Third Dose of an Inactivated COVID-19 Vaccine
This is a phase Ⅳ follow-up clinical trial based on the previous Phase Ⅳ clinical trial of an inactivated COVID-19 vaccine (CoronaVac) manufactured by Sinovac Life Sciences Co., Ltd.The purpose of this study is to evaluate the…
- Trial name
- NCT05329038
- Testing
- Inactivated COVID-19 Vaccine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Sedentary Behavior, Mental Health Wellness 1
Influence Physical Activity Psychological Responses COVID-19 Pandemic
The on-going Wuhan coronavirus (COVID-19) outbreak has become the world's leading health headline and is causing major panic and public concerns.
- Trial name
- NCT04352517
- Testing
- Online Survey
- Where
- 3 sites in Brazil, Chile and 1 more
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
COVID-19 Infection
Extension Study in a Cohort of Adult Patients With COVID-19 Infection
The main objective of this study is to evaluate the incidence of post-COVID morbidity and characterize the complications profile in patients who participated in the APLICOV-PC study.
- Trial name
- E-APLICOV-PC (NCT05121740)
- Testing
- Plitidepsin 1.5 mg / day, Plitidepsin 2.0 mg / day, Plitidepsin 2.5 mg / day
- Where
- 10 sites in Spain
- Volunteers
- 34 people
- Sponsor
- PharmaMar
COVID-19
TXA and Corona Virus 2019 (COVID19) in Outpatients
A controlled trial of the drug tranexamic acid (TXA) in outpatients who were recently diagnosed with COVID-19. It is hypothesized that TXA will reduce the infectivity and virulence of the virus.
- Trial name
- TCOutpatient (NCT04338074)
- Testing
- Tranexamic acid tablets
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Covid19
A Study of Inhaled Ampion in Adults With Respiratory Distress Due to COVID-19
This is phase II study to evaluate the safety and efficacy of inhaled Ampion in adults with respiratory distress due to COVID-19
- Trial name
- NCT04868890
- Testing
- Ampion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
COVID-19, SARS-CoV-2
A Study of AZD1222, a Vaccine for the Prevention of COVID-19 in Immunocompromised Adults
The aim of this study is to assess the immunogenicity and safety of AZD1222 for prevention of COVID-19 in immunocompromised adults.
- Trial name
- VICTORIA (NCT05057897)
- Testing
- AZD1222
- Where
- 4 sites in Thailand, Ukraine
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Respiratory Failure, Acute Respiratory Failure Requiring Intubation
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated…
- Conditions
- Respiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, Pneumonia
- Trial name
- NCT02399878
- Testing
- Inspiratory oxygen
- Volunteers
- 70,000 people
- Sponsor
- Massachusetts General Hospital
Sepsis, Acute Respiratory Distress Syndrome
Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARDS
In this interventional clinical trial, researchers will administer electroacupuncture versus sham electroacupuncture to sepsis patients with ARDS and collect objective outcome measures. The study will be divided into 2 groups.
- Trial name
- NCT06006325
- Testing
- electroacupuncture treatment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tianjin Nankai Hospital
Healthy
Mental and Physical Well-Being of Frontline Health Care Workers During Coronavirus Disease 2019 (COVID-19)
Study to support the mental and physical well-being of US health care workers during the COVID-19 pandemic and ensure high-quality care for patients through Stress First Aid.
- Trial name
- COVER-HCW (NCT04723576)
- Testing
- Stress First Aid
- Where
- 2 sites in United States
- Volunteers
- 7,444 people, healthy volunteers welcome
- Sponsor
- RAND
Pneumonia, Probiotics
Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia
The study goal is to determine whether oral administration of a probiotic mixture can reduce the incidence of antibiotic-associated diarrhea in patients with community-acquired pneumonia.
- Conditions
- Pneumonia, Probiotics, Diarrhea
- Trial name
- PROBIO (NCT06990568)
- Testing
- Lacidofil
- Volunteers
- 100 people
- Sponsor
- National Health Insurance Service Ilsan Hospital
Covid19
Risk Stratification and Early Alerting Regarding COVID-19 Hospitalization
The purpose of this research is to remotely monitor individuals who have tested positive for COVID-19 to learn more about progression and recovery from the disease.
- Trial name
- RiskSEARCH (NCT04709068)
- Testing
- Current Health
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Current Health
Post-COVID19 Condition
Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study
PAX is a prospective, randomized (1:1), double-blind, placebo-controlled study, that have as a objective to evaluate the safety and tolerability of plasma exchange (PE) in patients with Post Acute Covid-19 Syndrome (PCC)…
- Trial name
- NCT05445674
- Testing
- Plasma Exchange Procedure
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Long COVID, Post COVID-19 Condition
Investigating the Effectiveness of Vimida
This randomized controlled trial (RCT) with 160 patients suffering from fatigue after COVID-19 infection aims to investigate the effectiveness of the unguided digital therapeutic vimida for reducing post-COVID-19 fatigue.
- Trial name
- InvidiCO (NCT06251518)
- Testing
- vimida
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Gaia AG
Covid19
Factors Influencing the COVID-19 Vaccine Immune Response According to Age and Presence or Not of a Past History of COVID-19
Age is the main risk factor associated with the severity of COVID-19. From the beginning of the vaccination campaign, elderly subjects are part of the priority population.
- Trial name
- COVIMMUNAGE (NCT05047718)
- Testing
- COVID-19 vaccine Pfizer (3 doses), COVID-19 vaccine Pfizer (2 doses), COVID-19 mRNA Vaccine Moderna (3 doses)
- Where
- 2 sites in France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Severe Pneumonia
Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study
This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe…
- Trial name
- MASS (NCT06114784)
- Testing
- Metagenomics
- Where
- 15 sites in China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Covid19
Pegylated Interferon - α2b With SARSCoV- 2 (COVID-19)
This is a phase II, multicenter, open-label, randomized, comparator-controlled study to evaluate the efficacy and safety of Pegylated Interferon -α2b in the treatment of adult patients diagnosed with SARS-CoV2 (COVID-19).Initial…
- Trial name
- NCT04480138
- Testing
- Pegylated Interferon-α2b, Standard of Care
- Where
- 2 sites in Mexico
- Volunteers
- 7 people
- Sponsor
- Zydus Lifesciences Limited
Pneumonia, Pneumocystis Carinii, HIV Infections
A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients
To evaluate the effectiveness of atovaquone (566C80) compared to a standard antipneumocystis agent, (SMX/TMP), for the treatment of mild to moderate Pneumocystis carinii pneumonia (PCP) in AIDS patients.
- Trial name
- NCT00000655
- Testing
- Atovaquone, Sulfamethoxazole-Trimethoprim
- Where
- 38 sites in United States, Belgium and 6 more
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)