Clinical trials: Lung Lesions
Lesion, Lung Cancer
Real-Time Optical Biopsy in Improving Lung Cancer Diagnosis in Patients Undergoing Lung Biopsy
This pilot early phase I trial studies how well real-time optical biopsy works in improving lung cancer diagnosis in patients undergoing lung biopsy.
- Conditions
- Lesion, Lung Cancer, Diagnoses Disease
- Trial name
- NCT03376971
- Testing
- Biopsy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Arizona
Esophagus Injury, Atrial Fibrillation
Prevalence and Predictors of Esophageal Thermal Lesions in High-power-Short-duration Ablation of Atrial Fibrillation
Patients with documented atrial fibrillation who were referred to our clinic for catheter ablation will undergo standard HPSD ablation and subsequent esophagoscopy.
- Trial name
- VISUAL-AF (NCT05709756)
- Where
- 2 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Helios Health Institute GmbH
Lung Cancer, Tuberculosis
A Trial of Radial EBUS Versus VBN for the Peripheral Pulmonary Lesions
Peripheral pulmonary lesions are of growing importance in respiratory field. Early detection of lung cancer, tuberculosis and other diseases often needs a bronchoscopic investigation with different types of navigation.
- Conditions
- Lung Cancer, Tuberculosis, Pneumonia
- Trial name
- NCT05739695
- Testing
- Virtual bronchoscopy navigation, radial EBUS
- Where
- 6 sites in Russia
- Volunteers
- 118 people
- Sponsor
- Ilya Sivokozov
Lung Carcinoma Metastatic in the Brain, Stage IV Lung Non-Small Cell Cancer AJCC v7
Pembrolizumab and Magnetic Resonance Imaging With Ferumoxytol in Treating Patients With Non-small Cell Lung Cancer and Brain Metastases
This pilot phase II trial study evaluates the usefulness of the ferumoxytol steady state magnetic resonance imaging (MRI) technique for response assessment after pembrolizumab and radiation therapy in non-small cell lung cancer…
- Trial name
- NCT03325166
- Testing
- Ferumoxytol, Laboratory Biomarker Analysis, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Lung Cancer
VBN-EBUS-GS-TBLB With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the feasibility, efficacy and safety of transbronchial lung biopsy (TBLB) and bronchial brushing by using virtual bronchoscopic navigation (VBN) combined with endobronchial ultrasound…
- Trial name
- NCT02484066
- Testing
- VBN, EBUS-GS, X-ray
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Jiayuan Sun
Lung Cancer
Comparing Diagnostic Yield Between R-EBUS Guided Cryo Biopsy Vs. CT Guided Biopsy for PPL
Obtaining a tissue sample to diagnose a PPL suspected of cancerous origin is of utmost importance. The current gold standard; Transthoracic CT guided needle biopsy approach with a success rate of >90% comes at the expense of an…
- Trial name
- CT-CROP (NCT02395939)
- Testing
- CT guided core biopsy, Cryo-biopsy via Radial EBUS navigation
- Where
- New Zealand
- Volunteers
- 158 people
- Sponsor
- Middlemore Hospital, New Zealand
Cystic Fibrosis
A Study of Sweat Testing Using a Quantitative Patch
The primary aim of the study is to determine if the CF Quantum Sweat Test provides sweat chloride results that are equivalent to the results from traditional sweat testing.
- Trial name
- NCT01345617
- Where
- 3 sites in United States
- Volunteers
- 170 people
- Sponsor
- Polychrome Medical, Inc.
Sarcoma
BORIS - aBlação pOR mIcro-ondaS [Microwave Ablation]
Patients with sarcoma and lung metastases have few therapeutic options, with poor response to systemic treatment. Many of them are not eligible to surgical treatments due to the high number and distribution of pulmonary lesions…
- Trial name
- BORIS (NCT04510714)
- Testing
- Image guided percutaneous microwave ablation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Atrial Fibrillation
SOLAR & ATRILAZE Atrial Fibrillation Trial
The purpose of study is to conduct a pivotal evaluation of the EndoPhotonix™ SOLAR™ System and ATRILAZE™ System in order to obtain a labeling claim on the devices for the treatment of atrial fibrillation.
- Trial name
- SAAF-T (NCT00734058)
- Testing
- Laser MAZE by Ablation of Cardiac Tissue
- Volunteers
- 90 people
- Sponsor
- EndoPhotonix, Inc.
Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions
Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions
Dacryocystitis and nasolacrimal duct obstruction are the main common causes of epiphora. Dacryocystorhinostomy (DCR) is a widely used and effective treatment for dacryocystitis and nasolacrimal duct obstruction.
- Conditions
- Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions, Color Doppler Ultrasound, Computed Tomography
- Trial name
- NCT05500950
- Testing
- CDU and CT-DCG or CT examination
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Wenzhou Medical University
Atrial Septal Defects, Ventricular Septal Defects
Evaluation of Latent Pulmonary Arterial Hypertension in Congenital Shunt Lesions
Prospective, monocentric study for the evaluation of latent pulmonary arterial hypertension in patients with congenital shunt lesions lost to follow-up. Lost to follow-up is defined as latest clinical control ≥ 5 years.
- Trial name
- NCT02552485
- Testing
- No intervention was applied, because it is an observational study
- Where
- Belgium
- Volunteers
- 93 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Lesions, Robotic Assisted Bronchoscopy
Robotic-assisted Bronchoscopy Under Moderate Sedation With Propofol
In this study, the investigators want to find out whether robot-assisted bronchoscopy also works with moderate sedation (Propofol), as is already used in standard bronchoscopies. The study is being conducted as a pilot study.
- Conditions
- Lung Lesions, Robotic Assisted Bronchoscopy, Propofol, Bronchoscopy
- Trial name
- Robofol (NCT07006311)
- Testing
- Robotic-assisted bronchoscopy under propofol
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Primary Immune Deficiency
A Prospective Monocentric Study to Assess the Concordance of Lung MRI Compared to Chest CT Scan to Assess the Extent and Severity of Bronchial and Parenchymal Pulmonary Lesions in Adult Patients With Primary Immune Deficiency (PID) .
Currently, there is no official recommendations for the respiratory surveillance of patients with PID.However, it is recommended to perform a chest CT scan each 5 years or before any significant therapeutic change.
- Trial name
- IRMvsSCANNER (NCT05476653)
- Testing
- MRI procedure
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopital Foch
Lung Neoplasm
Feasibility of Mobile-CT-Assisted Bronchoscopy for the Diagnosis of Lung Lesion
This study investigates whether using a mobile-CT-assisted bronchoscopy (M-CAB) during a bronchoscopy procedure will better enable the study staff to reach the lung tumor, perform a biopsy, and obtain a diagnosis.
- Trial name
- NCT04995172
- Testing
- Computed Tomography, Electronic Health Record Review, Endobronchial Ultrasound Bronchoscopy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- M.D. Anderson Cancer Center
Peripheral Lung Lesions
The Effectiveness and Safety of Electromagnetic Navigation Real-time Guided Percutaneous Lung Biopsy
The goal of this clinical trial is to evaluate the diagnostic efficacy and safety of percutaneous lung biopsy guided by electromagnetic navigation real-time positioning technology in peripheral lung lesions.
- Trial name
- NCT05799014
- Testing
- CT-guided percutaneous lung biopsy, Percutaneous lung biopsy guided by electromagnetic navigation real-time positioning technology
- Volunteers
- 200 people
- Sponsor
- China-Japan Friendship Hospital
Dysplasia, Metaplasia
Erlotinib Hydrochloride in Preventing Cancer in Patients With Precancerous Lesions of the Lung
This phase I trial studies the side effects and best dose of erlotinib hydrochloride in preventing cancer in patients with precancerous lesions of the lung.
- Conditions
- Dysplasia, Metaplasia, Pulmonary Precancerous Condition
- Trial name
- NCT01013831
- Testing
- Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer, Extensive-stage Small-cell Lung Cancer
Durvalumab Combined With Consolidation Radiotherapy After First-line Treatment in Extensive Stage Small Cell Lung Cancer With Oligometastases
In patients with oligometastatic (1-5 lesions) extensive-stage small cell lung cancer, to explore the efficacy and safety of Durvalumab immunotherapy combined with chemotherapy followed by consolidation radiotherapy, to provide…
- Conditions
- Lung Cancer, Extensive-stage Small-cell Lung Cancer, Radiotherapy
- Trial name
- NCT05484583
- Testing
- Durvalumab + carboplatin/cisplatin + etoposide, Consolidation radiotherapy, Durvalumab
- Volunteers
- 58 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
SARS-COV2
Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients
The coronavirus disease (COVID-19) epidemic represents a major therapeutic challenge. The highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) and the long duration of the disease have led to a massive…
- Trial name
- NICOVID (NCT04608201)
- Testing
- Nicotine 7 mg/ 24h Transdermal Patch - 24 Hour
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Persistent Atrial Fibrillation
Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation
The overall objective of the study is to compare and assess the clinical outcomes of the standard of care hybrid ablation using epicardial ablation in conjunction with endocardial PVI alone versus epicardial ablation in…
- Trial name
- NCT02344394
- Testing
- Medtronic Cryoballoon, Thermocool Catheter, nContact
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Lung Cancer
Functional Imaging in Lung SBRT
Little is known about the safety of body radiation therapy (SBRT), especially the impact on pulmonary function, quality of life, and on functional changes within the lung itself.
- Trial name
- NCT03121300
- Testing
- CT Scan, Lung CT, MRI
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan Rogel Cancer Center