Clinical trials: Lung Lesions
Carcinoma, Non-Small-Cell Lung
A Study to Examine Biomarkers From Lung and Blood Samples in Participants With Suspected Lung Cancer
The purpose of this study is to assess spontaneous residual viable tumor cells (RVT) in the surgically resected tumor (Non-small cell lung cancer [NSCLC]).
- Trial name
- NCT04951154
- Testing
- Bronchoscopic Biopsy, Blood Sample
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Janssen Research & Development, LLC
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Heart Defects, Congenital, Pulmonary Arterial Hypertension
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions
Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality.
- Conditions
- Heart Defects, Congenital, Pulmonary Arterial Hypertension, Genetic Testing
- Trial name
- NCT02691689
- Testing
- Genetic testing
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Lesions, Mediastinal and Hilar Lymph Node Enlargement
A Study of Contrast-enhanced EBUS in Lung Lesions and Intrathoracic Lymph Nodes
Exploring the Clinical Application Value of Contrast Enhancement Features in CE-EBUS Images for the Diagnosis of Pulmonary Lesions and Intrapulmonary Lymph Nodes
- Trial name
- NCT07060378
- Testing
- Contrast-enhanced endobronchial ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer Metastatic
K-SAB Trial - Sotorasib Followed by SBRT to 1-3 Lesions in Advanced NSCLC With KRASG12C Mutation
The goal of this interventional study is to learn about the combination of sotorasib and stereotactic radiation therapy (SBRT) in patients with metastatic non-small cell lung cancer (NSCLC) with KRASG12C mutations.
- Trial name
- K-SAB (NCT06127940)
- Testing
- Stereotactic body radiation therapy (SBRT), Temporary Stopping
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska University Hospital
Bronchiolitis Obliterans, Acute Obliterating Bronchiolitis
Use of Clarithromycin in Mustard-Induced Bronchiolitis
We looked for the effectiveness of low-dose long-term prescription of clarithromycin in mustard-induced chronic pulmonary lesions, especially bronchiolitis obliterans
- Trial name
- NCT00381147
- Testing
- Clarithromycin
- Where
- Iran
- Sponsor
- Baqiyatallah Medical Sciences University
Peripheral Pulmonary Nodules
Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions
To collect data on diagnostic yield of thin and ultrathin bronchoscopes with radial probe endobronchial ultrasound (radial EBUS) and transbronchial needle aspiration (TBNA) during routine standard of care bronchoscopy for…
- Trial name
- NCT04331587
- Testing
- BF-P190 4 mm thin bronchoscope, BF-MP190F 3 mm ultrathin bronchoscope, Radial ultrasound probe (UM S20-17S)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Pulmonary Lesions
Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO)
With the advent of CT screening for lung cancer, there is an increase in the detection of pulmonary lesions with focal pure ground-glass opacity (pGGO).
- Trial name
- pGGO (NCT01429649)
- Testing
- cryotherapy or radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Cystic Fibrosis
A Study of Sweat Testing Using a Quantitative Patch
The primary aim of the study is to determine if the CF Quantum Sweat Test provides sweat chloride results that are equivalent to the results from traditional sweat testing.
- Trial name
- NCT01345617
- Where
- 3 sites in United States
- Volunteers
- 170 people
- Sponsor
- Polychrome Medical, Inc.
Cystic Fibrosis, Adherence, Medication
The Impact of Patch Rx Technologies on Adherence to Vitamin and Trikafta Therapies in Patients With Cystic Fibrosis
This proposed pilot study will assess if the Patch Technology system will increase adherence in patients with cystic fibrosis followed at the UTHSCSA Cystic Fibrosis Center.
- Trial name
- NCT04684823
- Testing
- Patch Cap, Patch App
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Small-cell Lung Cancer, Residual Tumor
Chemoimmunotherapy Plus Residual Lesion Irradiation for the Treatment of Extensive Stage Small-cell Lung Cancer
This is a phase II trial studies the effect of chemoimmunotherapy sequential residual tumor irradiation in treating patients with extensive stage small cell lung cancer.
- Conditions
- Small-cell Lung Cancer, Residual Tumor, Radiation
- Trial name
- NCT06514118
- Testing
- residual tumor irradiation
- Where
- 3 sites in China
- Volunteers
- 70 people
- Sponsor
- Qingdao Central Hospital
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD
Oral Lesions, COVID-19
Prevalence of Oral Lesions in COVID-19 Patients
Recently, a new coronavirus disease 2019 (COVID-19) has appeared and caused an unprecedented pandemic which is considered as an urgent threat to health authorities worldwide.
- Conditions
- Oral Lesions, COVID-19, Angiotensin-converting Enzyme 2
- Trial name
- NCT04917549
- Testing
- detection of oral lesions
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Kafrelsheikh University
Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions
Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions
Dacryocystitis and nasolacrimal duct obstruction are the main common causes of epiphora. Dacryocystorhinostomy (DCR) is a widely used and effective treatment for dacryocystitis and nasolacrimal duct obstruction.
- Conditions
- Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions, Color Doppler Ultrasound, Computed Tomography
- Trial name
- NCT05500950
- Testing
- CDU and CT-DCG or CT examination
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Wenzhou Medical University
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Intravenous Indocyanine Green for Localization of Intra-thoracic Lesions
This is a clinical trial to evaluate the intravenous administration of indocyanine green (ICG) as a method of intra-thoracic lesion localization.
- Trial name
- NCT03097627
- Testing
- ICG Intervention, Near Infrared Camera
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Brigham and Women's Hospital
Lung Cancer, Secondary Lung Cancer
Conventional Bronchoscopy Plus Rose Versus Electromagnetic Navigation (EMN) Plus Rose in Small Peripheral Lesions
The aim of this study is to evaluate if Electromagnetic navigation (ENB) in combination with rapid on site evaluation (ROSE) can improve diagnostic accuracy in those patients who fail to be diagnosed with conventional…
- Conditions
- Lung Cancer, Secondary Lung Cancer, Benign Lung Lesions
- Trial name
- NCT00880945
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Atrial Fibrillation
Lesion Formation With Pulsed Field Versus Cryobaloon Ablation as Assessed by Cardiac Magnetic Resoncance
This randomised study will compare pulsed field ablation and cryoballoon ablation with respect to ablation lesion quality as assessed by late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) at 3 months…
- Trial name
- PULSED-ICE-CMR (NCT06220006)
- Testing
- Pulmonary vein isolation
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Clinic of Barcelona
Lung Neoplasm
Exploration of Optical Coherence Tomography-Guided Transbronchial Biopsy in Peripheral Pulmonary Lesions
In this prospective analysis, investigators collected and evaluated data from patients who underwent TBB at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital.
- Trial name
- OCTGTBIPPL (NCT06419114)
- Testing
- Optical Coherence Tomography
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sichuan Provincial People's Hospital
Breast Cancer, Benign Breast Condition
ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health
AUDIBLE is a multi-site, clinical study conducted in the United States aimed at gathering data on 3D Automated Breast Ultrasound imaging using the iSono Health ATUSA system.
- Conditions
- Breast Cancer, Benign Breast Condition, Breast Fibroadenoma, Breast Neoplasms
- Trial name
- AUDIBLE (NCT07505797)
- Testing
- ATUSA 3D Automated Breast Ultrasound System
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- iSono Health, Inc.