Clinical trials: Lung Lesions
PET/CT, COVID-19
Study for Quantitative Analysis of the Recovered COVID-19 Patients by 18F-FDG-PET/CT
In this study, clinically cured patients with severe COVID-19 were used to evaluate the therapeutic effect of COVID-19 and the recovery and health status of patients over time with highly sensitive PET/CT imaging technology.
- Conditions
- PET/CT, COVID-19, Respiratory Function, Inflammatory Lesions
- Trial name
- NCT04519255
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Lung Cancer, Peripheral Lung Lesions
Diagnosing peRipheral Lung Lesions With CRYO Biopsies
Lung cancer is the leading course of cancer related deaths world-wide. Lung cancer screening will increase the number of small lung lesion in need of biopsy to confirm the diagnosis.
- Trial name
- DR CRYO (NCT06844344)
- Testing
- forceps biopsies, Cryo biosies
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Non Small Cell Lung Cancer, Lung Metastases
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis ≥ G3.
- Trial name
- STRILL (NCT04455438)
- Testing
- SBRT dose escalation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Vaccination; Infection, COVID-19
Establishing Immunogenicity and Safety of Needle-free Intradermal Delivery of mRNA COVID-19 Vaccine
COVID-19 vaccines are limited in supply, especially in low- and middle-income countries, leading to substantial morbidity and mortality.
- Trial name
- MILESTONE (NCT05315362)
- Testing
- solid microneedle skin patch, mRNA-1273, standard needle
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Stage III Non-small-cell Lung Cancer
Radiotherapy Dose Complement in the Treatment of Hypoxic Lesions Patients With Stage III Non-small-cell Lung Cancer
This study will assess the efficacy and safety of a radiotherapy dose complement (boost) in the treatment of hypoxic lesions, measured by F-miso PET/CT, in patients with stage III NSCLC not amenable to surgery and candidate for…
- Trial name
- RTEP-5 (NCT01576796)
- Testing
- Radiotherapy
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Henri Becquerel
Lung Neoplasms
A Study of Robot-Assisted Bronchoscopy in Chinese Participants With Lung Lesions
Robot-assisted bronchoscopy biopsy procedure will be conducted for all eligible subjects under general anesthesia status by trained investigators in hospital.
- Trial name
- NCT05426213
- Testing
- Robot-assisted Bronchoscopy (Monarch Platform)
- Sponsor
- Auris Health, Inc.
Lung Cancer, Stereotactic Body Radiotherapy
Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System
Stereotactic Body Radiotherapy (SBRT) delivers an ablative dose of radiation to tumours, with high precision. This technique offers an alternative to surgery for lung lesions.
- Conditions
- Lung Cancer, Stereotactic Body Radiotherapy, Lung Diseases, Lung Cancer Metastatic
- Trial name
- SBRT_LOV (NCT06722885)
- Testing
- Standard radiotherapy treatment
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Lung Cancer
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak.
- Trial name
- NCT04954625
- Testing
- Autologous Blood Patch, Standard of Care (per Physician)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Lung Cancer, Multiple Pulmonary Nodules
Real World Registry for Use of the Ion Endoluminal System
The primary objective of this study is to evaluate the performance of the Ion Endoluminal System with real-world use for pulmonary lesion localization or biopsy.
- Conditions
- Lung Cancer, Multiple Pulmonary Nodules, Lung Neoplasms, Respiratory Tract Neoplasms
- Trial name
- NCT06004440
- Testing
- Ion Endoluminal System
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Intuitive Surgical
Lung Cancer
Cost-effectiveness Evaluation of Robotic Surgery in the Removal of Lung Lesions in the ATS of Milan
The goal of this observational study is to compare cost-effectiveness of robotic surgery with open surgery and video-assisted thoracoscopy surgery (VATS) in adult patients, resident in the ATS of Milan area, operated for lung…
- Trial name
- NCT05674227
- Testing
- Robotic surgery, Video-assisted thoracoscopy, Open surgery
- Volunteers
- 5,400 people
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Lung Lesion(s) Requiring Evaluation
Transbronchial Lung Biopsy Guided by ENB
The purpose of this study is to evaluate the performance and safety of electromagnetic navigation bronchoscopy (ENB) system and system kit (iLungTM SuperNavigator) .
- Trial name
- NCT03628222
- Testing
- ENB-TBLB, X-ray-TBLB
- Where
- 8 sites in China
- Volunteers
- 226 people
- Sponsor
- Changzhou LungHealth Medtech Company Limited
Elastography
Application of Ultrasonic Elastography in Lung Lesions
Elastography is an imaging of tissue elasticity or stiffness and is currently emerging as a mainstream tool for ultrasound-based diagnosis.
- Trial name
- NCT02636985
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Peripheral Lung Lesions
Localization of Peripheral Pulmonary Lesions: A Pilot Study
Despite technological advancements directed towards the diagnosis of peripheral pulmonary lesions, an optimal approach has yet to be designed.
- Trial name
- NCT03536026
- Testing
- Conventional bronchoscopy, VIDA Pulmonary Workstation 2, Biopsy
- Sponsor
- Washington University School of Medicine
Lung Neoplasms, Diagnosis
Benefit of Cone-beam CT and Robotic-Assisted Bronchoscopy During Bronchoscopy
This randomized controlled trial evaluates the integration of cone-beam computed tomography (CBCT) and robotic-assisted bronchoscopy (RAB) for diagnosing pulmonary lesions, hypothesizing improved diagnostic yield compared to…
- Conditions
- Lung Neoplasms, Diagnosis, Lung Cancer
- Trial name
- NCT06489678
- Testing
- Robotic Assisted Bronchoscopy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary
The Watch the Spot Trial
This study will compare two clinically accepted protocols for surveillance imaging in individuals who are found to have a small pulmonary nodule on chest computed tomography (CT) scans.
- Conditions
- Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms, Carcinoma, Non-small-cell Lung
- Trial name
- WTS (NCT02623712)
- Testing
- More Frequent Surveillance Strategy, Less Frequent Surveillance Strategy
- Where
- United States
- Volunteers
- 34,686 people
- Sponsor
- Kaiser Permanente
Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung
Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING Study
This phase II trial studies the use of Ion robotic bronchoscope with a mobile computed tomography (CT) scanner to biopsy tumors and inject a fluorescent dye called indocyanine green to mark the tumor during surgery in patients…
- Conditions
- Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung, Stage I Lung Cancer AJCC v8
- Trial name
- NCT04987281
- Testing
- Computed Tomography, Indocyanine Green Solution, Therapeutic Bronchoscopy
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Peripheral Pulmonary Lesion
Evaluate the Diagnostic Value of BTPNA for PPL: a Real-world Study
The study is designed as a multicenter prospective trial of BTPNA for the diagnosis of peripheral pulmonary lesions in the real world.
- Trial name
- NCT04597346
- Testing
- Bronchoscopic Transparenchymal Nodule Access
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Smoking Cessation
Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer
The goal of this clinical research study is to offer lung cancer screenings to smokers who want to change their smoking behaviors.
- Trial name
- NCT03059940
- Testing
- Questionnaires, Low Dose Computed Tomography Scan, Shared Decision Making + Video
- Where
- United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Lung Cancer, Pneumothorax
Effectiveness of the Autologous Blood Patch Method in Lung Biopsies
In this retrospective study, investigators aimed to evaluate the effectiveness of the autologous blood patch method in percutaneous transthoracic lung biopsies performed with the coaxial technique.
- Trial name
- NCT05904574
- Testing
- Autologous blood patch, Percutaneous transthoracic biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Trakya University