Clinical trials: Lung Lesions
Brain Metastases, Generalized Malignancy, Primary
Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases
The main purpose of this study is to see whether addition of TPI 287 to FSRT is safe and tolerable. Researchers also want to find out if adding TPI 287 to FSRT can help with better controlling the growth of brain lesions in…
- Conditions
- Brain Metastases, Generalized Malignancy, Primary, Brain Lesions
- Trial name
- NCT02187822
- Testing
- TPI 287, Fractionated Stereotactic Radiotherapy (FSRT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Peripheral Pulmonary Nodules, Ablation Techniques
Diagnosis and Treatment of Lung Lesions
To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).
- Trial name
- NCT07642986
- Testing
- A single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Jisong Zhang
Pulmonary Coin Lesion
Pilot Study to Measure Lung Biopsy Diagnostic Yield Using Always On Electromagnetic Tip Tracked Devices
The objective of the prospective, multi-center study is to evaluate the ease of use and effectiveness of the SPiN Drive Electromagnetic (EM) Tip Tracked Steerable Devices as a method of sampling subsegmental, less than 3.0 cm…
- Trial name
- ALOSPNDY (NCT01389154)
- Testing
- Lung biopsy using Always On EM Tip Tracked Device
- Sponsor
- Veran Medical Technologies
Lung Nodule, Lung Mass
Cone Beam CT Guided Robotic Navigational Bronchoscopy
Navigational bronchoscopy (NB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lung Cancer
- Trial name
- CBCTRNB (NCT05358041)
- Testing
- Robotic Bronchoscopy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbus Regional Health
Peripheral Pulmonary Lesion
Diagnostic Value of UTB and TB for PPL
The purpose of the study is to evaluate the diagnostic value and safety of ultrathin and thin bronchoscope (UTB and TB) for peripheral pulmonary lesions (PPLs) without X-ray fluoroscopy.
- Trial name
- NCT04571476
- Testing
- Ultrathin bronchoscope, Thin bronchoscope, Virtual bronchoscopic navigation combined with endobronchial ultrasound
- Where
- China
- Volunteers
- 578 people
- Sponsor
- Shanghai Chest Hospital
Lung Carcinoma Metastatic to the Brain
MRI Perfusion on T1 and T2 Brain Lesion(s)
This study therefore aims to assess current treatment recommended by scientific societies [ 6-13 ] , brain MRI with injection of contrast for the diagnosis and monitoring of brain metastases .
- Trial name
- METAPERF (NCT02250755)
- Testing
- MRI T1 T2 sequences
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Lung Neoplasms, Diagnosis
Benefit of Cone-beam CT and Robotic-Assisted Bronchoscopy During Bronchoscopy
This randomized controlled trial evaluates the integration of cone-beam computed tomography (CBCT) and robotic-assisted bronchoscopy (RAB) for diagnosing pulmonary lesions, hypothesizing improved diagnostic yield compared to…
- Conditions
- Lung Neoplasms, Diagnosis, Lung Cancer
- Trial name
- NCT06489678
- Testing
- Robotic Assisted Bronchoscopy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Oral Lesions, COVID-19
Prevalence of Oral Lesions in COVID-19 Patients
Recently, a new coronavirus disease 2019 (COVID-19) has appeared and caused an unprecedented pandemic which is considered as an urgent threat to health authorities worldwide.
- Conditions
- Oral Lesions, COVID-19, Angiotensin-converting Enzyme 2
- Trial name
- NCT04917549
- Testing
- detection of oral lesions
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Kafrelsheikh University
Stereotactic Body Radiation Therapy, Lung Lesions
Impact of a Hypnotic Recording on Artifacts in 4D CT in the Context of Stereotactic Body Radiation Therapy for Lung Cancer
This is a single-center prospective cohort study evaluating the impact of a simple audio recording hypnosis system on the occurrence of artifacts on 4D CT scans in patients requiring SBRT radiotherapy for lung lesions (peripheral…
- Trial name
- HYPNOCT-4D (NCT07334990)
- Testing
- Hypnotic record
- Volunteers
- 25 people
- Sponsor
- Centre Leon Berard
Lung Cancer, Pneumothorax
Effectiveness of the Autologous Blood Patch Method in Lung Biopsies
In this retrospective study, investigators aimed to evaluate the effectiveness of the autologous blood patch method in percutaneous transthoracic lung biopsies performed with the coaxial technique.
- Trial name
- NCT05904574
- Testing
- Autologous blood patch, Percutaneous transthoracic biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Trakya University
Mechanical Ventilation, Tracheal Intubation
Simple Mechanical Device to Control Pressure in the Balloon of the Endotracheal Tube to Prevent Ventilator-acquired Pneumonia
Hypothesis: Nosten® device is able to reduce the time of underinflated balloon and removes excess pressure. This device may thus reduce the risk of ventilator-acquired pneumonia (VAP) and early tracheal lesions resulting from…
- Conditions
- Mechanical Ventilation, Tracheal Intubation, Ventilator-acquired Pneumonia, Intubation -Related Tracheal Lesions
- Trial name
- PAV-PROTECT (NCT02514655)
- Testing
- Nosten® pressure control (it's not an antibiotic, but simple device), Manual pressure control
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Pulmonary Lesions
Study on the Influence of Fluoroscopy in the Diagnosis of Peripheral Lung Lesions With Endobronchial Ultrasound Guidance
The purpose of this study is to determine whether the use of fluoroscopy improves the diagnostic yield of peripheral pulmonary lesions' biopsy guided by radial endobronchial ultrasound (with the use of a guide sheath).
- Trial name
- NCT01863836
- Testing
- Fluoroscopy, Radial EBUS-guided biopsy
- Where
- Canada
- Volunteers
- 133 people
- Sponsor
- Laval University
Non-small Cell Lung Cancer, Pancreatic Cancer
EGF Ointment for Erlotinib Skin Lesion
Epidermal growth factor receptor-tyrosin kinase inhibitor (EGFR-TKI, Erlotinib) has demonstrated its efficacy in patients with non-small cell lung cancer and pancreatic cancer.
- Trial name
- NCT01593995
- Testing
- Epidermal growth factor (EGF) ointment
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Dong-A University Hospital
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Cryobiopsy Versus Forceps Biopsy for Pulmonary Lesions
Purpose: Patients with peripheral lung nodules require evaluation for lung cancer. Our aim is to assess the diagnostic yield of a new technique, transbronchial cryobiopsies, in patients at risk for lung cancer.
- Trial name
- NCT02983903
- Testing
- transbronchial biopsy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pennsylvania
Pulmonary Function Test, Phrenic Nerve Irritation
Physical Therapy on Phrenic Nerve Function
This study was conducted to investigate the effects of a designed physical therapy program on respiratory function and phrenic nerve activity in cervical disc compression.
- Conditions
- Pulmonary Function Test, Phrenic Nerve Irritation, Cervical Disc Lesion
- Trial name
- NCT05817565
- Testing
- Ultrasound (Phyaction 190 I); with a frequency of 3 MHz was used
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Lung Diseases
Post-Market Optimization Study of the EMPOWER® RF Catheter to Ablate Soft Tissue Lesions in the Lung
A post-market study to assess the performance and safety of a RF ablation catheter to bronchoscopically ablate lung lesions will be evaluated in patients with confirmed diagnosis of non-small cell lung cancer or metastatic lung…
- Trial name
- NCT04131777
- Testing
- Radiofrequency (RF) catheter
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Broncus Medical Inc
Lung Cancer, Peripheral Pulmonary Lesions
EBUS-Miniprobes Sampling for Peripheral Lung Lesions
There is an interest in characterazing asymptomatic peripheral lung lesions beacause they could be an early form of neoplasm. These lesions are invisible in the endoscopic exam, so the samples must be made with a guiding…
- Trial name
- NCT03422744
- Testing
- trans bronchial biopsy guided by echo-endoscopic miniprobes, if first one negative: samples under fluoroscopic control
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Lung Cancer, Pulmonary Nodule
A Retrospective Multicenter Review to Evaluate the Performance of the Ion Endoluminal System in Sampling Pulmonary Lesions
This study is a retrospective multi-center chart review of patients who underwent an attempted biopsy of one or more pulmonary lesion(s) with the Ion Endoluminal System with the aim of assessing the overall performance of the…
- Trial name
- NCT05160571
- Testing
- Ion Endoluminal System
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Intuitive Surgical
Pulmonary Lesions, Pulmonary Nodules
Ultrathin Bronchoscope and Radial Endobronchial Ultrasound (R-EBUS) With Fluoroscopy Versus Standard Fiberoptic Bronchoscopy (FB) (P00029233 )
The purpose of this study is to compare the yield of two methods for obtaining a lung tissue sample: Procedure #1: standard fiberoptic bronchoscopy (FB) with fluoroscopy, and Procedure #2: ultrathin bronchoscope procedure with…
- Conditions
- Pulmonary Lesions, Pulmonary Nodules, Pulmonary Mass
- Trial name
- NCT02146131
- Testing
- Standard FB with fluoroscopy, R-EBUS with ultrathin bronchoscope
- Where
- 5 sites in United States
- Volunteers
- 339 people
- Sponsor
- Medical University of South Carolina
Lung Cancer
Prospective Cohort of Diagnostic Bronchoscopy for Peripheral Lung Lesions
The primary objective is To evaluate the usefulness and safety of advanced guided bronchoscopy for histological diagnosis of peripheral pulmonary lesions.
- Trial name
- NCT05804786
- Testing
- Guided bronchoscopy
- Where
- 11 sites in South Korea
- Volunteers
- 1,240 people
- Sponsor
- Seoul National University Bundang Hospital