Clinical trials: Lung Mechanics
Copd
Impact of Inhaled PT003 on Complexity and Variability of Tidal Breathing and Oscillatory Mechanics in Stable COPD Patient
Prospective, single-arm, open label, multicentre, phase II pilot study to evaluate the immediate and short term (one month) impact of a new long acting double bronchodilator on innovative parameters in stable and moderate to…
- Trial name
- OSCIVARI (NCT04087590)
- Testing
- Formoterol-glycopyrronium co suspension (PT003)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Lille
Anesthesia
Effect of mgso4 on Oxygenation and Lung Mechanics in Morbidly Obese Patients During Bariatric Surgery
The purpose of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery
- Trial name
- NCT04769440
- Testing
- mg sulphate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
ARDS, Lung Protective Ventilation
Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors, leading to refractory hypoxemia. It has high incidence and mortality rates.
- Trial name
- ARDS (NCT06514209)
- Testing
- cisatracurium
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate
Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Chronic obstructive pulmonary disease (COPD) patients often undergo thoracic surgery due to lung cancer and emphysematous changes.
- Conditions
- Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe, Lungcancer
- Trial name
- NCT02962999
- Testing
- Ketamine, Saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Congenital Heart Disease
Effect of Retrograde Autologous Blood Priming on Pulmonary Mechanics in Pediatric Cardiac Surgery
The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.
- Trial name
- RAPCPB (NCT04260204)
- Testing
- Pediatric cardiac surgery
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
Elastic Tape Relieves Symptoms and Improves Health-related Quality of Life in COPD (Chronic Obstructive Pulmonary Disease)
The goal of this randomized controlled trial is to investigate the effects of elastic tape in individuals with mild to very severe COPD.
- Trial name
- COPD (NCT04415957)
- Testing
- Elastic Tape
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Acute Respiratory Distress Syndrome
Maneuver for Evaluating the Potential Recruitability of the Pulmonary Parenchyme in Patients With ARDS
This study will try to define the threshold of the recruitable volume (Vrec), obtained by a derecruitment maneuver, that permit to identify patients responder or not to alveolar recruitment maneuvers.
- Trial name
- MERP (NCT04387669)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Caen
Laparoscopy, Positive End Expiratory Pressure (PEEP)
Effects of Different Peep Applications on Tissue Oxygenation, Respiratory Mechanics and Postoperative Pulmonary Complications in Laparoscopic Hysterectomy Operations
This study aims to compare the effects of two different PEEP levels (5 cmH₂O and 10 cmH₂O) during laparoscopic hysterectomy on perioperative tissue and cerebral oxygenation, respiratory mechanics, and postoperative pulmonary…
- Conditions
- Laparoscopy, Positive End Expiratory Pressure (PEEP), Respiratory Mechanics
- Trial name
- NCT07105293
- Testing
- PEEP 5 cmH2o applied group, PEEP 10 cmH2o applied group
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Atelectasis
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning.
- Trial name
- optiPEEP (NCT04900714)
- Testing
- Decremental PEEP, Lung ultrasound score, Blood gas analysis
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Acute Respiratory Distress Syndrome, Acute Lung Injury
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
This study will examine the hypothesis that iloprost maintains and improves ventilation perfusion matching in patients with pulmonary hypertension and ARDS/ALI as reflected by 1) an improved PaO2/FIO2 ratio as calculated from the…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Pulmonary Hypertension
- Trial name
- NCT01274481
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Ventilator-Induced Lung Injury, Lung Ventilator
Respiratory Mechanics During One-lung Ventilation
Intraoperative lung protective ventilatory strategy has been widely recognized to reduce postoperative pulmonary complications in laparotomy and laparoscopic surgeries.
- Conditions
- Ventilator-Induced Lung Injury, Lung Ventilator, One-lung Ventilation
- Trial name
- NCT04519606
- Testing
- Optimal lung compliance during OLV
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- E-DA Hospital
Brain Injuries
Influence of Respiratory Mechanics on Brain-specific Monitoring in Brain-injured Patients
Increase in intracranial pressure (ICP) could be associated with increase in positive end-expiratory pressure (PEEP) level. Data are however disparate and interactions between ventilation with high PEEP and intracranial…
- Trial name
- ABIVENT (NCT04013698)
- Testing
- PEEP level 5 cmH2O, PEEP level 15 cmH2O
- Where
- Switzerland
- Sponsor
- Piquilloud Imboden Lise
Pulmonary Infection
Expiratory Rib Cage Compression in Mechanically Ventilated Patients
This is a randomized crossover study, designed to evaluate if the manual expiratory rib cage compression technique improves respiratory mechanics and is effective in secretion removal in mechanically ventilated patients.
- Trial name
- NCT01525121
- Testing
- Expiratory Rib Cage Compression
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Centro Universitário Augusto Motta
Anesthesia
Assessment of Airways Mechanical Properties by FOT and LIR During Anesthesia
The aims of the present study are: 1. To evaluate the effect of the induction of anaesthesia and paralysis in terms of changes in oscillatory mechanics parameters 2.
- Trial name
- NCT01506284
- Testing
- Forced oscillatory technique (FOT) and laser interferometry (LIR).
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Uppsala University Hospital
Chronic Obstructive Pulmonary Disease
Asymptomatic Versus Symptomatic Mild COPD: Comparisons at Rest and at Exercise
The current definition of chronic obstructive pulmonary disease (COPD) is based on the presence of persistent airflow obstruction assessed by spirometry. About half of the subjects with mild COPD (i.e.
- Trial name
- NCT02235025
- Testing
- Cardio-pulmonary exercise testing
- Where
- France
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Preterm Birth, Respiratory Distress Syndrome
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
Lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (FRC).
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Lung Diseases
- Trial name
- NCT02493920
- Testing
- Sustained lung inflation, mask using a T-piece system (Fabian,Acutronic Medical Systems AG, Switzerland).
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico