Clinical trials: Lung Nodule
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary
The Watch the Spot Trial
This study will compare two clinically accepted protocols for surveillance imaging in individuals who are found to have a small pulmonary nodule on chest computed tomography (CT) scans.
- Conditions
- Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms, Carcinoma, Non-small-cell Lung
- Trial name
- WTS (NCT02623712)
- Testing
- More Frequent Surveillance Strategy, Less Frequent Surveillance Strategy
- Where
- United States
- Volunteers
- 34,686 people
- Sponsor
- Kaiser Permanente
Lung Neoplasms
Pre-operative Localization of Ground Glass Solitary Pulmonary Nodules
Objectives: The main drawback of the hook-wire technique for locating ground glass nodules before video assisted thoracoscopic surgery (VATS) resection is the risk of the hook dislodging during single lung ventilation as the lung…
- Trial name
- SLIDINGWIRE (NCT06195657)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Carcinoma, Non-Small-Cell Lung
SLND or Not in cT1 GGO Invasive Lung Adenocarcinoma (ECTOP-1009)
This is a study from Eastern Cooperative Thoracic Oncology Project, numbered as ECTOP-1009. Systematically mediastinal lymph node dissection or not in clinical stage T1 ground-glass dominated invasive lung adenocarcinoma: a…
- Trial name
- NCT04527419
- Testing
- No mediastinal lymph node dissection
- Where
- China
- Volunteers
- 545 people
- Sponsor
- Fudan University
Peripheral Pulmonary Nodules
Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions
To collect data on diagnostic yield of thin and ultrathin bronchoscopes with radial probe endobronchial ultrasound (radial EBUS) and transbronchial needle aspiration (TBNA) during routine standard of care bronchoscopy for…
- Trial name
- NCT04331587
- Testing
- BF-P190 4 mm thin bronchoscope, BF-MP190F 3 mm ultrathin bronchoscope, Radial ultrasound probe (UM S20-17S)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Progression
A Prospective, Two-center, Single Arm Phase II Clinical Study to Evaluate Safety and Effectiveness of Ablation Therapy in the Treatment of Lung Cancer Presenting as Ground-glass Nodules
A prospective, two-center, single arm phase II clinical study to evaluate safety and effectiveness of ablation therapy in the treatment of lung cancer presenting as ground-glass nodules
- Trial name
- NCT04905056
- Testing
- Ablation therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Solitary Lung Nodule, Multiple Pulmonary Nodules
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules
Some studies have shown that the model for judging and predicting the growth of sub-solid pulmonary nodules through big data and deep learning can detect nodule growth earlier.
- Trial name
- NCT06458673
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Cancer
Safety and Effectiveness of Disposable Pulmonary Surgical Markers in the Localization of Pulmonary Nodules
During the VATS procedure, some pulmonary nodules are relatively small or far away from the pleura, resulting that they are difficult to be accurately located during the procedure.
- Trial name
- NCT04139408
- Testing
- Disposable Pulmonary Surgical Marker
- Where
- 3 sites in China
- Volunteers
- 76 people
- Sponsor
- Hangzhou Broncus Medical Co., Ltd.
Lung Nodules
Bronchoscopic Approach to the Peripheral Lung Nodule - Endobronchial Ultrasound, Electromagnetic Navigation and Cryobiopsy
In patients with peripheral lung nodules, what is the additional diagnostic yield of biopsies obtained with flexible cryoprobes compared to standard techniques? For patients with peripheral nodules, we hypothesize use of the…
- Trial name
- NCT02196974
- Testing
- cryobiopsy
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Calgary
Solitary Pulmonary Nodules
Near Infrared Fluorescence Imaging With Indocyanine Green
This research study will evaluate how Near Infrared Fluorescence imaging (NIFI) with indocyanine green (ICG) contrast dye can assist in the identification and diagnosis of lung nodules during surgery.
- Trial name
- NIFI-ICG (NCT02851368)
- Testing
- near infrared fluorescence imaging (NIFI), Indocyanine Green
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Pulmonary Cancer
Quantification of microRNAs in Diagnosis of Pulmonary Nodules
One of the main challenges of thoracic oncology lies in earlier diagnosis of lung cancer to improve survival rate, wich is about 15% at 5 years. This poor prognosis is often linked to late diagnosis.
- Trial name
- miR-Nod (NCT03293433)
- Testing
- Blood punction
- Where
- 2 sites in France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Toulouse
Lung Cancer (Diagnosis)
Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.
Evaluate FlowPath Lung Diagnostic Test of Sputum Samples to Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, >6 to <30 mm in Diameter, Determined by LDCT.
- Trial name
- BA-004 (NCT07168993)
- Testing
- Standard medical treatment
- Where
- 11 sites in United States
- Volunteers
- 2,063 people
- Sponsor
- bioAffinity Technologies Inc.
Neoplasms
Chest Imaging of Lung Nodule(s) Under High-frequency Non-invasive Ventilation (HF-NIV)
Imaging of chest disorders is mainly achieved by using computed tomography. This is especially the case for detection, morphologic assessment and followup of pulmonary nodules.
- Trial name
- NCT03553368
- Testing
- HF-NIV-MR, HF-NIV-PET, MR
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Pulmonary Nodule, Liposomal Bupivacaine
Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in VATS Partial Pneumonectomy
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive approach for partial pneumonectomy, but postoperative pain remains a major challenge affecting recovery.
- Trial name
- NCT07512635
- Testing
- Bupivacaine Hydrochloride, Bupivacaine liposome
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Sanming First Hospital
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules
Correlate performance of LungLB Test with outcome of a scheduled biopsy.
- Trial name
- NCT05171491
- Where
- 12 sites in United States
- Volunteers
- 425 people
- Sponsor
- LungLife AI
Pulmonary Nodules, Early Stage Lung Cancer (I and II)
Tubeless Strategy for Enhanced Recovery After Sublobar Resection
This is a prospective, randomized controlled clinical trial conducted at a single center. The study aims to evaluate whether a "tubeless" strategy can enhance recovery for patients undergoing minimally invasive thoracoscopic…
- Conditions
- Pulmonary Nodules, Early Stage Lung Cancer (I and II), Thoracoscopic Surgery, Sublobar Resection
- Trial name
- NCT07409129
- Testing
- Laryngeal Mask Airway, Thoracic Paravertebral Block with Local Anesthetic, Non-intubated Anesthesia
- Where
- China
- Volunteers
- 138 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer
Osimertinib to Suppress the Progression of GGN(EGFR Mutation-positive)
This study designed to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR mutation-positive stage I lung…
- Trial name
- NCT04591002
- Testing
- Osimertinib 80 MG
- Where
- 2 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Lung Cancer
Thoracoscopic Localization of Pulmonary Nodules Using Direct Intracavitary Thoracoscopic Ultrasound
Pulmonary nodules are one of the most common thoracic radiographic abnormalities. They are usually found accidentally as discrete well emarginated pulmonary lesions found within the lung parenchyma during a routine chest x-ray.
- Trial name
- CT0007 (NCT01201824)
- Testing
- intracavitary ultrasound
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pulmonary Nodules, Early-Stage Lung Cancer
Application of Electromagnetic Navigation System in Pulmonary Nodule Localization
This study aims to design and conduct a multicenter, prospective, randomized controlled post-market clinical trial to validate the clinical efficacy of high-precision electromagnetic navigation technology.
- Trial name
- NCT07595120
- Testing
- Electromagnetic Navigation-Guided Percutaneous Localization of Pulmonary Nodules, CT-Guided Percutaneous Localization of Pulmonary Nodules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Lung Nodules, Biopsy
Efficacy and Safety of Robotic-assisted Bronchoscopy Combined With the ICNVA Strategy in Biopsy of Peripheral Pulmonary Nodules
To assess the efficacy and safety of robotic-assisted bronchoscopy system (bronchial navigation and positioning device) combined with ICNVA strategy for peripheral pulmonary nodule biopsy through a prospective, single-center…
- Conditions
- Lung Nodules, Biopsy, Navigation, Spatial
- Trial name
- NCT07136961
- Testing
- Robot-Assisted Bronchoscopy (RAB)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Lung Nodules
Clinical Study of Trap-(FAPI)3 PET Imaging in the Diagnosis of Pulmonary Nodules
The excellent tumor-targeting efficacy of FAP has been confirmed by multiple clinical studies. The results unequivocally establish FAPI as a tumor-targeting ligand with significant potential, demonstrating important application…
- Trial name
- NCT07448441
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University