Clinical trials: Lung Pathogenesis
Asthma, Obesity
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
The purpose of this study is to examine whether there are higher levels of cysteinyl leukotrienes in obese subjects than in non-obese subjects.
- Trial name
- NCT01158573
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Michigan
COPD Exacerbation
Biomarker of Acute Exacerbation of COPD
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease.
- Trial name
- NCT04963244
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cystic Fibrosis
Viral Pathogenesis of Early Cystic Fibrosis Lung Disease
The purpose of this study is to test the hypothesis that early viral infections alter the bacterial flora and inflammatory profile in the airway and accelerate progression of pulmonary disease in infants with cystic fibrosis.
- Trial name
- Early CF (NCT01973192)
- Where
- 4 sites in United States, Australia
- Volunteers
- 65 people
- Sponsor
- Indiana University
COPD
Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)
This research is being conducted to examine the effects of nasal insufflation of warm and humidified air through a small nasal cannula on sleep, breathing pulmonary function, and daytime exercise capability.
- Trial name
- NCT01764165
- Testing
- Oxygen, High flow of room air
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infection, Pulmonary Hypertension
Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension
The purpose of this study is to describe the epidemiology of pulmonary hypertension in individuals with HIV infection and to investigate its pathogenesis.
- Conditions
- HIV Infection, Pulmonary Hypertension, Endothelial Function, HIV Infections
- Trial name
- NCT00845013
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- University of California, San Francisco
Chronic Rejection in Lung Transplant, Cytokine Production in Bos Post Lung Transplant
Early Indicators of Chronic Rejection in Lung Transplant
The purpose of this research is to discover the different patterns of cytokine production in patients who may develop Bronchiolitis Obliterans Syndrome-0p (BOS-0p) which means ongoing rejection.
- Trial name
- BOS (NCT00449332)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Influenza With Pneumonia, Invasive Pulmonary Aspergillosis
Influenza Associated Aspergillosis In-depth Investigation
This trial is aimed to study the immunological and pathological characteristics of influenza versus non-influenza severe community-acquired pneumonia patients in ICU.
- Trial name
- PIAS (NCT03748069)
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
HIV Infections, Emphysema
Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center
Despite the availability of highly active antiretroviral therapy (HAART), lung diseases remain a leading cause of morbidity and mortality in those with HIV infection.
- Conditions
- HIV Infections, Emphysema, Chronic Obstructive Pulmonary Disease, Pneumocystis
- Trial name
- MACS (NCT00870857)
- Where
- 2 sites in United States
- Volunteers
- 407 people
- Sponsor
- University of Pittsburgh
Respiratory Tract Infections, Tuberculosis, Pulmonary
TB Sequel: Pathogenesis and Risk Factors of Long-term Sequelae of Pulmonary TB
This is an observational cohort study. Pulmonary tuberculosis (TB) patients will be enrolled at the time of TB diagnosis and prospectively followed for at least two years after TB-treatment initiation with optional prolonged…
- Trial name
- TBSEQUEL (NCT03251196)
- Testing
- No Intervention, and Observational Study
- Where
- 4 sites in Mozambique, South Africa and 2 more
- Volunteers
- 1,500 people
- Sponsor
- The Aurum Institute NPC
Lymphangiomatosis, Lymphedema
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Background: Lymphatics are a type of vessel, similar to arteries and veins. Lymphatic disorders happen when these vessels don t work properly.
- Conditions
- Lymphangiomatosis, Lymphedema, Lymphangiectasia, Pulmonary Lymphangiectasia
- Trial name
- NCT02156115
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease
Evaluation of the Causes and Disease Processes of Chronic Lung Disease
Chronic lung diseases are disorders associated with abnormalities in any of the structures involved in the process of breathing and bringing oxygen into the lungs and blood.
- Trial name
- NCT00001183
- Where
- United States
- Volunteers
- 6,564 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease
Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease
This study will last for 5 years (2021.2.25-2025.12.31). 210 patients (70 cases in each group) will be enrolled in this study. Eight centers in China will participate in the study.
- Trial name
- NCT04849104
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Asthma
Viral Inception of Asthma: Prospective Study From Infancy to School-age
The purpose of this study is to study prospectively the early clinical and immunological events in children susceptible to rhinovirus induced early wheezing (i.e., recently found highest risk factor for recurrent wheezing/asthma)…
- Trial name
- VINKU2 (NCT00731575)
- Testing
- prednisolone
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Turku
Pulmonary Hypertension
Prevalence, Pathogenesis, and Prognosis of Pulmonary Hypertension in Dialysis Patients
This prospective multicenter longitudinal study aims to investigate the prevalence, pathogenesis, and prognosis of pulmonary hypertension in patients with end-stage renal disease undergoing chronic hemodialysis.
- Trial name
- NCT07563608
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lung Disease, Pneumothorax
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Conditions
- Lung Disease, Pneumothorax, Tuberous Sclerosis, Lymphangioleiomyomatosis
- Trial name
- NCT00001465
- Testing
- Toshibia Aquilion One CT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Immature Platelets, Deep Venous Thrombosis
Immature Plateletes in the Etiopathology of Deep Venous Thrombosis
The study is designed to evaluate the role of platelets and immature platelets in the ethiopathology of deep venous thrombosis and pulmonary embolism.
- Trial name
- iPLATELET (NCT02361294)
- Testing
- Blood samples
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Pulmonary Disease, HIV
Lung HIV Disease in a Large Cohort-Pitt
HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected patients, and it has been hypothesized that this accelerated disease progression is the result of one or more latent infections that…
- Conditions
- Pulmonary Disease, HIV, Emphysema
- Trial name
- MACS (NCT01326572)
- Where
- 2 sites in United States
- Volunteers
- 189 people
- Sponsor
- University of Pittsburgh
Healthy, Asthma
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase 1
The purpose of the study is to determine the role of nitric oxide (NO) in asthma. We determine the effect of promoter polymorphisms in the gene for the NO producing enzyme, nitric oxide synthase (NOS2), on exhaled NO in healthy…
- Trial name
- NCT00671229
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Kartagener Syndrome
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease
The overall short-term goals of this project include the following: 1) identify the genes that are key to the function of respiratory cilia to protect the normal lung; and 2) the effects of genetic mutations that adversely affect…
- Trial name
- NCT00807482
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Lung Diseases, Hypertension, Pulmonary
Genetic and Environmental Characteristics of Primary Pulmonary Hypertension
The goal of this study is to identify the modifying genes and environmental features that regulate the clinical expression of mutations in bone morphogenetic protein receptor 2 (BMPR2); to develop the understanding of how BMPR2…
- Trial name
- NCT00091546
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University