Clinical trials: Lung Surgery
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
Non Small Cell Lung Cancer
Multicentric Analysis of Predictors of N1 Upstaging After Resection of cStage-I NSCLC
Five papers showed a lower N1 nodal upstaging with video-assisted thoracic surgery (VATS) compared to open surgery in patients with cStage-I NSCLC .
- Trial name
- NUTS (NCT02730897)
- Testing
- Central/Peripheral
- Volunteers
- 956 people
- Sponsor
- University Hospital, Gasthuisberg
Postoperative Complications, Abdominal Surgery
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
- Trial name
- REMAIN-1 (NCT05556174)
- Testing
- periodic lung recruitment maneuvers
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Non Small Cell Lung Cancer, Stage III Lung Cancer
Post-operative Radiotherapy After Neodjuvant Chemo-immunotherapy and Surgery in Stage III NSCLC
This study investigates whether postoperative radiotherapy (PORT) improves outcomes for patients with stage III non-small cell lung cancer (NSCLC) who have residual disease after neoadjuvant chemo-immunotherapy and surgery.
- Trial name
- RESCUE (NCT06878274)
- Testing
- Post-operative radiotherapy
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
End-stage Lung Disease
BREATHE Study: Spontaneous Breathing-Preserved Anesthesia and Surgical Strategy for Hospital Recovery in Lung Transplantation
The goal of this study is to learn whether a spontaneous-breathing ("tubeless") anesthesia and surgery strategy can improve early recovery and remain safe for adults who receive a lung transplant.
- Trial name
- BREATHE-LTx (NCT07384546)
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer
Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer.
- Trial name
- NCT00897117
- Testing
- gene expression analysis, microarray analysis, protein expression analysis
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Cardiac Perfusion
Del Nido Cardioplegia Randomized Trial
The use of a modified depolarizing cardioplegia solution in adult cardiac surgery would allow for prolonged re-dosing intervals while providing equivalent myocardial protection.
- Trial name
- NCT02442050
- Testing
- del Nido solution, Blood-based cardioplegia
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Inova Health Care Services
COVID-19
COVID-19 Surveillance of Patients and Healthcare Workers in a Hospital Department
Doctors, nurses and staff members of ear-nose and throat (ENT) departments are at high risk due to aerosol-inducing diagnostic procedures and surgery during the COVID-19 epidemic.
- Trial name
- NCT04356560
- Testing
- COVID-19 test, polymerase chain reaction for SARS-CoV-2
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lung Cancer, Non Small Cell Lung Cancer
Perioperative Rehabilitation in Operation for Lung Cancer
Background: Improved surgical techniques combined with effective adjuvant chemotherapy, has led to a better survival in individuals with NSCLC.
- Trial name
- PROLUCA (NCT01893580)
- Testing
- Experimental: 1. Experimental, Experimental: 2. Experimental, Experimental: 3. Experimental
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lung Surgery, Enhanced Recovery After Surgery, ERAS
Evaluation of the Effectiveness of Enhanced Recovery After Surgery (ERAS) Program in Pediatric Lung Surgery
This study aims to evaluate the clinical effectiveness of the Enhanced Recovery After Surgery (ERAS) program for pediatric lung surgery at our institution.
- Conditions
- Lung Surgery, Enhanced Recovery After Surgery, ERAS, Pediatric
- Trial name
- NCT07241286
- Testing
- Enhanced Recovery After Surgery, ERAS
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Scoliosis, Restrictive Pulmonary Disease
Cardiorespiratory Assessment Prior to Scoliosis Surgery: a 10-year Experience at a Specialized Scoliosis Center
this study involves adult patients who underwent scoliosis surgery within the last 10 years. The aim of this study is to assess the frequency of scoliosis-related respiratory complications in patients requiring orthopedic…
- Conditions
- Scoliosis, Restrictive Pulmonary Disease, Pulmonary Hypertension, Restrictive Breathing Pattern
- Trial name
- RespiSco (NCT07760441)
- Testing
- respiratory function test
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Poitiers University Hospital
Lung Cancer, Stage IIIA-cN2
Molecular Signature From Tumor to Lymph Nodes
Mediastinal lymph node (LN) involvement (N2) in non-small cell lung cancer (NSCLC) concerns 15% of resectable tumors and is associated with a poor prognosis and an overall survival reaching 9 to 49%.
- Conditions
- Lung Cancer, Stage IIIA-cN2, Operated With Curative Intent, Primary Tumor Tissue Available
- Trial name
- N2-3S (NCT04677205)
- Where
- 12 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Vein Thrombosis, Pulmonary Embolism
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin
The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT03516656
- Testing
- Standard heparin dose, Real time heparin dose adjustment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Lung Diseases, Interstitial
Interstitial Lung Disease (ILD). Diagnostic Yield of Surgical Lung Biopsy Versus Cryobiopsy in the Same Surgical Stage.
In patients with interstitial lung disease (ILD) with inconsistent clinical and radiological features, establishing a reliable diagnosis of ILD requires a surgical lung biopsy Transbronchial cryobiopsy is a minimally invasive…
- Trial name
- NCT03596528
- Testing
- Lung biopsy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Pulmonary Arterial Hypertension, Right Ventricular Dysfunction
Consistency of Electrical Cardiometry and Pulmonary Artery Catheter
Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios.
- Trial name
- NCT05587400
- Testing
- passive leg raising, dobutamine test, inhaled nitric oxide
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer Stage I, Lung; Node
Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection
In patients undergoing minimally invasive thoracoscopic surgery (video-assisted thoracoscopic surgery, or VATS), a still unsolved issue is represented by intraoperative alveolar air leaks (IOAALs), which if prolonged beyond the…
- Conditions
- Lung Cancer Stage I, Lung; Node, Air Leak From Lung
- Trial name
- NCT06544200
- Testing
- Polymeric Hydrogel Matrix
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University Hospital Padova
Shoulder Pain, Laparoscopic Surgery
Reducing Shoulder Tip Pain Following Laparoscopic Surgery
Laparoscopic surgery is becoming a major procedure, owing to smaller incisions, shorter hospitalizations, and less post-operative pain as compared with traditional laparotomies.
- Trial name
- NCT01135836
- Testing
- Pulmonary recruitment maneuver, Intraperitoneal normal saline, Control group
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
URTI, Postoperative Complications
Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic
The goal of this observational study is to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional…
- Conditions
- URTI, Postoperative Complications, COVID - 19, Elective Non-cardiac Surgery
- Trial name
- URTI (NCT07157111)
- Where
- China
- Volunteers
- 2,392 people
- Sponsor
- aijun xu
Surgery, Pain
Evaluation of the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain After Laparoscopic Cholecystectomy in Ambulatory Care
Known to reduce analgesics and length of hospitalization in conventional surgery, laparoscopy is characterized by frequent post-operative pain and can decrease the patient's quality of immediate postoperative life and sometimes…
- Trial name
- VSD (NCT02819544)
- Testing
- Sodium chloride administration, Ropivacaine administration
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk