Clinical trials: Lung Transplant Recipients
Lung Diseases, Depression
Investigational Study of Psychological Intervention in Recipients of Lung Transplant (INSPIRE)
The purpose of this study is to examine the effectiveness of a telephone-based cognitive behavioral therapy intervention to alleviate psychological distress among lung transplant patients.
- Trial name
- INSPIRE (NCT00113139)
- Testing
- Telephone-based coping skills/stress management, Usual Care
- Volunteers
- 389 people
- Sponsor
- Duke University
Graft Dysfunction, Interstitial Fibrosis
Novartis Everolimus Transition
Transition from tacrolimus based triple therapy with Mycophenolate Mofetil (MMF) and steroids in stable renal transplant patients to low intensity tacrolimus, everolimus and prednisone will be associated with improvement in…
- Trial name
- NCT02096107
- Testing
- Everolimus, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
SARS-CoV-2
A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult Participants
This is an open-label study to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1273 Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) vaccine in adults with a kidney or liver solid organ transplant (SOT)…
- Trial name
- NCT04860297
- Testing
- mRNA-1273
- Where
- 15 sites in United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Pulmonary, Pneumonia
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop…
- Conditions
- Pulmonary, Pneumonia, Hematopoietic System--Cancer
- Trial name
- NCT05041140
- Testing
- 29-XeMRI imaging
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Sleep Wake Disorders, Lung Transplantation
Low-Frequency rTMS for In-Hospital Sleep Disturbance After Lung Transplantation
This randomized, double-blind, sham-controlled trial will evaluate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve in-hospital sleep quality in adult lung transplant recipients during early…
- Trial name
- TMS-SLEEP-LTx (NCT07796425)
- Testing
- Active Low-Frequency Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 152 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Heart Transplant Patients, Kidney Transplant Patients
Multidisciplinary Non-Pharmacological Intervention to Improve Quality of Life in Solid Organ Transplant Recipients
This is a single-center interventional study aimed at evaluating the feasibility of a multidisciplinary non-pharmacological approach based on acupuncture, telerehabilitation-based physical rehabilitation, and brain health…
- Conditions
- Heart Transplant Patients, Kidney Transplant Patients, Lung Transplant, Liver Transplanted Patients
- Trial name
- TAO (NCT07870811)
- Testing
- Acupuncture, Telerehabilitation-Based Physical Rehabilitation, Psychological Support Program
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
For Oncologic Patients, Potentially Operable Lung Tumor
DECT Ventilation Imaging
Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation.
- Conditions
- For Oncologic Patients, Potentially Operable Lung Tumor, With a Recent (Less Than 1 Month) VQ Scan, For Lung Transplant Recipients
- Trial name
- NCT02377518
- Testing
- Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Transplant Rejection
An Open Label Trial Evaluating the Safety, Tolerability, Efficacy and Pharmacokinetic Profile of Tacrolimus Inhalation Powder in Adult Lung Transplant Recipients
Part A: This is an open label, single-arm study that will evaluate the safety, tolerability, efficacy and PK of Tacrolimus Inhalation Powder over 12 weeks in lung transplant patients who require reduced blood levels of tacrolimus…
- Trial name
- NCT05501574
- Testing
- Tacrolimus Inhalation Powder, Plastiape RS00 Dry Powder inhaler device
- Where
- 2 sites in Australia
- Volunteers
- 14 people
- Sponsor
- TFF Pharmaceuticals, Inc.
Constrictive Bronchiolitis, Bronchiolitis Obliterans
Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome
Background: Bronchiolitis obliterans or bronchiolitis obliterans syndrome is a lung disorder that occurs as a complication of either lung transplantation or bone marrow/blood stem cell transplantation.
- Conditions
- Constrictive Bronchiolitis, Bronchiolitis Obliterans, Graft vs Host Disease, Bronchiolitis, Exudative
- Trial name
- NCT01287078
- Testing
- Cyclosporine Inhalation Solution
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Covid19, Kidney Transplant Infection
Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients
An open-label, 56 day, single-center, exploratory, proof-of-concept study of the anti-viral effect of voclosporin (VCS) with an extended safety follow-up, up to 1 year.
- Trial name
- VOCOVID (NCT04701528)
- Testing
- Voclosporin, Tacrolimus
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
Lung Transplant, Well-Being, Psychological
A Study of Latin Dance for Post- Lung Transplant
The purpose of this research study is to see if participating in Latin dance for 12 sessions can improve wellbeing in several areas including balance, fear of movement, anxiety, depression and spirometry.
- Trial name
- NCT05924113
- Testing
- Latin Dance
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Chronic Rejection in Lung Transplant, Cytokine Production in Bos Post Lung Transplant
Early Indicators of Chronic Rejection in Lung Transplant
The purpose of this research is to discover the different patterns of cytokine production in patients who may develop Bronchiolitis Obliterans Syndrome-0p (BOS-0p) which means ongoing rejection.
- Trial name
- BOS (NCT00449332)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Lung Transplant Failure
Lung PGD Biomarkers in Organ Donors
PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive…
- Trial name
- NCT03089489
- Testing
- lung biomarkers in organ donor for PGD in lung recipient
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Pulmonary Veno-Occlusive Disease, Hepatic Veno-Occlusive Disease
Effects on Glutamine on the Outcome of Allogeneic Bone Marrow Transplant Recipients
The primary purpose of this project is to investigate if addition of glutamine, an amino acid, to standard parenteral nutrition, may improve the clinical outcome of the bone marrrow transplantation reducing the occurrence of…
- Conditions
- Pulmonary Veno-Occlusive Disease, Hepatic Veno-Occlusive Disease, Mucositis
- Trial name
- NCT00563498
- Testing
- Glutamine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Hospital Authority, Hong Kong
Hematopoietic Stem Cell Transplantation
Effects of Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Recipients
Stem cell transplantation is a process in which stem cells are harvested from either a patient's or donor's bone morrow or peripheral blood for intravenous infusion.
- Trial name
- NCT03625063
- Testing
- Exercise training group, Control training group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Lung Transplantation
Comparison of Two Chest Physiotherapy Protocols in Lung Transplant Recipients
Chest infection is a common complication following lung transplant (LTx). Chest physiotherapy is widely accepted as an integral part of the management of chest infections, however there is no evidence available regarding the…
- Trial name
- NCT00163891
- Testing
- Chest physiotherapy
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Bayside Health
Transplant Recipient
Upper Limb Exercise Capacity: Lung Transplant vs. Healthy Controls
Lung transplantation is a surgical intervention for end-stage lung diseases (e.g., COPD, cystic fibrosis, idiopathic pulmonary fibrosis).
- Trial name
- NCT07065981
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Kidney Transplant Recipients, Liver Transplant Recipients
COVID Protection After Transplant-Immunosuppression Reduction
This study will enroll individuals who have: Completed primary series of mRNA COVID-19 vaccine, and An antibody response ≤ 2500 U/mL measured at least 30 days after the last dose of vaccine.
- Trial name
- CPAT-ISR (NCT05077254)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine 2023-2024, Moderna COVID-19 Vaccine 2023-2024, SOC IS Regimen
- Where
- 15 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19, Kidney Transplant Infection
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle East
Methods: Out of 2000 kidney transplant recipients in our center in Kuwait, collecting data was started for all COVID-19-positive kidney transplant recipients till August 2020.
- Conditions
- Covid19, Kidney Transplant Infection, Risk Factor, Cardiovascular, Immunosuppression
- Trial name
- OMC-KTR (NCT04542954)
- Testing
- Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience from the Middle East
- Where
- Kuwait
- Volunteers
- 104 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico