Clinical trials: Lung Transplant Recipients
Lung Transplantation, Hypoxia
Adaptation of Lung Transplant Recipients at Extreme Altitude
This prospective observational study investigates the effects of intermittent hypoxic conditioning and real high-altitude exposure in lung transplant recipients compared with healthy controls.
- Conditions
- Lung Transplantation, Hypoxia, Altitude, High-altitude Adaptation
- Trial name
- NCT07479511
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Lung Diseases
Prophylaxis Guided by Cytomegalovirus-specific T Cell Immunity to Prevent Cytomegalovirus Disease in Lung Transplant Recipients
The purpose of this study is to evaluate the clinical outcomes of Cytomegalovirus (CMV) virus in the participants' body. Therefore, the study team will follow the participants' immunological response based on the Cytomegalovirus…
- Trial name
- NCT06494033
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Lung Transplant Infection, Fungal Infection
Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients
This is a single center, observational study of posaconazole PK sampling in lung transplant recipients. The patients enrolled will have up to 6 (3ml) pk samples (a total of 18 ml) and one 10ml blood sample for a total collection…
- Trial name
- NCT01419678
- Testing
- collection of blood samples for PK testing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Lung Transplant
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
The purpose of this study is to see if taking the study drug, Belumosudil, for 52 weeks in addition to your usual care and medication, will prevent Chronic Lung Allograft Dysfunction (CLAD) in participants who have a lung biopsy…
- Trial name
- CLAD (NCT06476132)
- Testing
- Belumosudil
- Where
- 12 sites in United States, Canada
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exhaled Breath Condensate
"Exhaled Breath Condensate" in Allogeneic Stem Cell Recipients and the Value in Follow-up
The most effective treatment of hematologic malignancies and some benign hematological diseases is allogeneic stem cell transplantation therapy. Pulmonary complications can occur after allogeneic stem cell transplantation.
- Trial name
- NCT02318316
- Testing
- Exhaled breath condensate
- Volunteers
- 80 people
- Sponsor
- Gazi University
Lung Diseases
Transplanting Hepatitis C Lungs Into Negative Lung Recipients
This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with…
- Trial name
- SHELTER (NCT03724149)
- Testing
- Zepatier, Epclusa
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Lung Transplantation, Chronic Obstructive Pulmonary Disease
Confocal Laser Micro-endoscopy in Chronic Obstructive Pulmonary Disease (COPD) and Lung Transplant Recipients
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described…
- Trial name
- NCT01204970
- Where
- Belgium
- Volunteers
- 176 people
- Sponsor
- KU Leuven
Endocrine System Diseases, Thyroid Diseases
Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
The aim of this study is to assess the impact of endocrine changes and their correction on survival and organ function in heart and lung transplant recipients.
- Conditions
- Endocrine System Diseases, Thyroid Diseases, Cortisol Deficiency, Diabetes Insipidus
- Trial name
- NCT04351945
- Testing
- Blood test
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Lung Transplantation, Influenza Vaccines
Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy
The purpose of this study is to test the specific humoral response after an intramuscular and intradermal influenza vaccination in lung transplant recipients
- Trial name
- NCT00402805
- Testing
- Trivalent Inactivated Influenza Vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Lung Transplant; Complications, Disability Evaluation
Assessment of Lung Transplant Recipients Within The Scope of International Classification of Functioning, Disability and Health
This study was aimed to evaluate the patients undergoing lung transplantation under the International Classification of Functionality, Disability and Health (ICF) and to examine the relationships between the age at which lung…
- Trial name
- NCT05376605
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Ankara City Hospital Bilkent
Solid Organ Transplant Recipients
TIXAGEVIMAB/CILGAVIMAB Protection of Covid-19 in Transplanted Patients
Covid-19 has a very bad prognosis in solid organ transplant recipients with a 60 days-mortality exceeding 20%. For this reason, transplant patients were prioritized to receive Covid-19 vaccination since December 2020 in France.
- Trial name
- TIXCI-TRANS (NCT05234398)
- Testing
- Blood and saliva samplings
- Where
- 2 sites in France
- Sponsor
- Hospices Civils de Lyon
Transplant Recipients
COVID-19 Research in Organ Transplant Recipients
COVID-19 is a global major public health emergency that disproportionately affects patients with risk factors such as advanced age, heart and lung disease, diabetes, hypertension, as well as compromised immunity.
- Trial name
- CORONA (NCT04407221)
- Where
- Sweden
- Volunteers
- 1,100 people
- Sponsor
- Vastra Gotaland Region
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
COVID19
Role of Immune and Inflammatory Response in Recipients of Allogeneic Haematopoietic Stem Cell Transplantation (SCT) Affected by Severe COVID19
COVID19 pandemic currently represents a public health emergency. Based on current data, 15% of the affected individuals will develop a severe form of the disease requiring admission to hospital and respiratory support.
- Trial name
- (COVID19_BMT) (NCT04349540)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Influenza Virus, Influenza Vaccine
Intradermal Versus Intramuscular Trivalent Influenza Vaccine in Adult Lung Transplant Recipients
The influenza virus, commonly called the flu, is a common source of infection in lung transplant patients and can often lead to pneumonia and possibly rejection.
- Trial name
- NCT00760175
- Testing
- Vaxigrip (Aventis-Pasteur Canada)
- Where
- 2 sites in Canada, Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Alberta
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Severely Underweight Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm clinical study is to learn whether a spontaneous breathing-preserving perioperative management strategy can improve recovery and is safe in lung transplant recipients with…
- Trial name
- NCT07384572
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Mycoses, Fungemia
Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients
- Conditions
- Mycoses, Fungemia, Central Nervous System Fungal Infections, Lung Diseases, Fungal
- Trial name
- NCT00841971
- Testing
- Anidulafungin, Fluconazole
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation
Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients
Introduction: After haematopoietic stem cell transplantation (HSCT), patients often experience complications such as respiratory difficulties, fatigue and decreased quality of life.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation, Inspiratory Muscle Training
- Trial name
- NCT07061444
- Testing
- Inspiratory Muscle Training, Functional Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ceren Derya Gültekin
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Bone Marrow Transplant
Pneumonia Vaccine in Bone Marrow Transplant Recipients: Usefulness of Donor Vaccination
Streptococcus pneumoniae, also known as Pneumococcus, is a common cause of pneumonia in transplant patients. There has been a vaccine available for this infection called Pneumovax.
- Trial name
- NCT00143780
- Testing
- The polysaccharide vaccine used is Pneumovax (Merck vaccines), The conjugate vaccine used is Prevnar (Wyeth-Ayerst vaccines)
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto