Clinical trials: Lupus Nephritis
Systemic Lupus
Immune Adsorption Role in Treatment of Resistant Lupus
Background: lupus is a heterogeneous autoimmune disease with autoantibodies formation. Lupus nephritis carries the worst prognosis. C1q deficiency correlates with activity and renal involvement and may help in its evaluation.
- Trial name
- HFR (NCT04108611)
- Testing
- hemodiafiltration with endogenous re infusion (HFR)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr. Mohamed Ahmed El ghiriani
Systemic Lupus Erythematosus, Lupus Nephritis
Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus
This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus
- Trial name
- NCT06796569
- Testing
- systemic immune inflammatory index
- Where
- Egypt
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Sohag University
Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures .
- Trial name
- NCT07017868
- Testing
- interleukin- 17
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Lupus Nephritis
Exploring Biomarkers for Therapeutic Response of Lupus Nephritis Based on Multi Omics Analysis
This is an observational study of patients with lupus nephritis aiming to find biomarkers that can predict patients' response to immunosuppressants.
- Trial name
- NCT06167174
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese SLE Treatment And Research Group
Lupus Nephritis, IgG4-related Disease
Safety and Efficacy of PRG-2311 for Refractory Lupus Nephritis and IgG4-Related Disease
A Clinical Study on the Safety and Effectiveness of CD19/BCMA Chimeric Antigen Receptor T Cells in the Treatment of Refractory Lupus Nephritis and IgG4-Related Disease.
- Trial name
- NCT06497361
- Testing
- PRG-2311
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Systemic Lupus Erythematosus
Study of Systemic Lupus Erythematosus
This protocol will evaluate patients with systemic lupus erythematosus (SLE) and their relatives to learn more about how the disease develops and changes over time.
- Trial name
- NCT00001372
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Lupus Nephritis
TF, TFPI and Plasmin as Novel Bio-markers in Early Diagnosis of Lupus Nephritis
Urinary levels of plasmin ,TF , and TFPI are all elevated in active LN patients compared to inactive LN patients and healthy controls. All four proteins correlated with systemic disease activity and renal disease activity.
- Trial name
- NCT04218890
- Testing
- Urinary tissue factor (TF), tissue factor pathway inhibitor (TFPI) and plasmin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Uromodulin, SLE
Uromodulin as a Biomarker in Lupus Nephritis
Evaluation of Uromodulin as a biomarker of renal histological activity/ Chronicity indices in lupus nephritis
- Trial name
- NCT07763834
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Lupus Nephritis
Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Introduction and background : Glomerulonephritis and auto-immune diseases are often associated. Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which have a severe impact on…
- Trial name
- GOODLUPUS (NCT03664908)
- Testing
- Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Lupus Nephritis
Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis
Mesenchymal Stem Cell (MSC) has been shown to have immunosuppressive and repairing properties. Manifestations of systemic lupus eryhematosus(SLE) may in most patients be ameliorated with medications that suppress the immune…
- Trial name
- NCT00659217
- Testing
- mesenchymal stem cell
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Organ Transplant Institute, China
Lupus Nephritis
Study to Assess the Efficacy and Safety of FK506 Combined With Mycophenolate Mofetil (MMF) in Lupus Nephritis (III/IV/V)
This is an open, prospective study to assess the efficacy and safety of Tacrolimus (FK506) combined with MMF in the treatment of class III, IV, V + IV or V + III lupus nephritis.
- Trial name
- NCT00298506
- Testing
- Multitherapy
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Lupus Nephritis
Urine Exosomes to Identify Biomarkers for LN
Urine exosomes will be extracted from patients with lupus nephritis, healthy controls, and patients with systemic lupus erythematosus without lupus nephritis.
- Trial name
- NCT04894695
- Testing
- biomarkers detection in different groups
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Lupus Nephritis
To Compare the Efficacy and Safety of FK506 vs IVC in the Treatment of Class III-IV LN
1. To compare the efficacy of FK506 vs intravenous cyclophosphamide pulses in the treatment of class III-IV LN. 2. To compare the safety and tolerability of FK506 vs intravenous cyclophosphamide pulses in the treatment of class…
- Trial name
- NCT00302549
- Testing
- FK506
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Proteinuria, Kidney Injury
Inflammatory and Immune Profiling of Kidney Tissue Obtained From Patients With Newly Diagnosed Kidney Disease
This study will evaluate in patients with kidney disease, the role that certain inflammatory and immune mediators play in promoting kidney damage.
- Conditions
- Proteinuria, Kidney Injury, Chronic Kidney Disease
- Trial name
- NCT01156428
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Lupus Nephritis, IgA Nephropathy
The Correlation of Periostin and Renal Pathology in Chronic Kidney Disease Patients
The purpose of this study is to determine the location of periostin and urine periostin level in patients with lupus nephritis and IgA nephropathy.
- Trial name
- NCT02493101
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Lupus Nephritis
Wellness & Workforce Solution for Lupus/Lupus Nephritis
The investigators will test the hypothesis that culturally congruent coaching delivered via a technology application (Health360x) will improve the persistent disparities observed among women of color with lupus or lupus nephritis…
- Trial name
- NCT06217107
- Testing
- Micro-learning content, Health360x app, Culturally congruent coaching
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
S100A8, Serum
S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis
This study aims to evaluate both serum and urine S100A8 as potential biomarkers for Lupus nephritis (LN)
- Conditions
- S100A8, Serum, Urine, Biomarker
- Trial name
- NCT06872138
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Lupus Nephritis
Anti-alpha-actinin Antibodies and Lupus Nephritis Activity
Lupus nephritis (LN) develops in 30-60% of systemic lupus erythematosus (SLE) patients and remains a leading cause of morbidity, with 10-30% progressing to end-stage renal disease within 15 years.
- Trial name
- NCT07505576
- Testing
- renal biopsy, serum anti-alpha-actinin antibodies, CBC, serum creatinine and urea, estimated GFR, ESR, CRP, urine analysis, ANA, anti dsDNA, C3 & C4, serum albumin, 24-hrs urinary protein, and U. ACR
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University