Clinical trials: Luteal Support
Infertility, Embryo Transfer
Progesterone as Luteal Support in Frozen IVF Natural Cycles
The ProFET study aims to investigate if luteal phase support by vaginal progesterone, is superior to no luteal phase support, in terms of live birth rate per woman after a frozen embryo transfer (FET), in a natural cycle (NC)…
- Trial name
- ProFET (NCT04725864)
- Testing
- Progesterone vaginal tablet
- Where
- Sweden
- Volunteers
- 1,800 people
- Sponsor
- Vastra Gotaland Region
Infertility
GnRHa for Luteal Phase Support in GnRH Antagonist Protocol Cycles
Evaluation of the effect of adding a single dose of gonadotropin releasing hormone agonist (GnRHa) as a luteal phase support on the outcomes of intracytoplasmic sperm injection (ICSI) following GnRH antagonist protocol
- Trial name
- NCT02312089
- Testing
- Triptorelin
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Infertility
Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)
The study to compare to the efficacy and safety of Crinone versus combination medication in infertile women receive frozen-thawed embryo transfer (FET) in artificial cycles (AC).
- Trial name
- NCT03858049
- Testing
- Crinone, Duphaston
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
IVF
RIOTC: Reducing the Impact of Ovarian Stimulation. Novel Approaches to Luteal Support in IVF-Study 2
The goal of the randomised controlled study (RCT) is to identify novel strategies that can improve the luteal phase endocrinology after ovarian stimulation, with the aim of using less or no luteal support in IVF while making the…
- Trial name
- RIOTC (NCT04524026)
- Testing
- Letrozole 5 mg
- Where
- 2 sites in Denmark
- Volunteers
- 25 people
- Sponsor
- Nicholas Macklon
Abnormal Menstrual Cycle
The Need for Luteal Support in NC-FET
The investigators are going to examine prospectively the need of luteal support after NC-FET.
- Trial name
- NCT01483365
- Testing
- Vaginal tablet Endometrin twice a day
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Wolfson Medical Center
Embryo Transfer, Luteal Support
Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study
This study evaluates the outcomes of frozen-thawed embryo transfer (FET) success rate with modified luteal support - addition of a single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively vs.
- Trial name
- NCT02825290
- Testing
- Choriogonadotropin alfa, Triptorelin acetate
- Where
- Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility
Evaluation of Different Luteal Phase Support Methods in Patients With Poor Ovarian Response
This study is a randomized clinical trial to investigate the efficacy of different luteal phase support methods in patients with poor ovarian response undergoing IVF and intracytoplasmic sperm injection (ICSI) cycles.
- Trial name
- NCT02798653
- Testing
- Choriomon® injection, Choriomon® injection+Endometrin ®, Endometrin ® vaginal tablets
- Where
- Iran
- Volunteers
- 210 people
- Sponsor
- Royan Institute
Infertility
Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle
To test the hypothesis that adding estradiol (E2) to progesterone supplementation later in the luteal phase of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, rather than earlier in the luteal phase…
- Trial name
- NCT01367912
- Testing
- estradiol tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Luteal Phase Defect
Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support
The purpose of this study is to compare efficacy and tolerability of the dydrogesterone and the vaginal progesterone, used for luteal phase support.
- Trial name
- NCT01178931
- Testing
- Oral dydrogesterone, Crinone 8% gel
- Where
- Croatia
- Volunteers
- 853 people
- Sponsor
- University of Zagreb
Female Infertility
Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support
Hormonal milieu during implantation is crucial to embryo-endometrium interaction and to the viability of the conceptus. Alterations in the peri-implantation environment are considered to impair perinatal outcomes in…
- Trial name
- NCT05286554
- Testing
- gonadotropin releasing hormone-agonist, Progesterone
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Alexandria University
IVF, Luteal Phase Defect
Luteal Phase Support In IVF Women Using GnRH Agonist
Lately, the role of GnRH agonist as luteal phase support has been recommended by various studies though the mechanism is still debatable.
- Trial name
- NCT04174378
- Testing
- Decapeptyl 0.2mg
- Where
- Malaysia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Infertility
Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG
Study Objectives: 1. To prove that the use of GnHR agonist for final oocyte maturation results in a higher percentage of mature oocytes than the use of hCG. 2.
- Trial name
- NCT01638026
- Testing
- TRIPTORELIN ACETATE, hCG
- Where
- Israel
- Volunteers
- 93 people
- Sponsor
- HaEmek Medical Center, Israel
Infertility
GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles
Evaluation of the effect of adding a single dose of gonadotropin releasing hormone agonist (GnRHa) as a luteal phase support on the outcomes of intracytoplasmic sperm injection (ICSI) following long GnRHa protocol
- Trial name
- NCT02312076
- Testing
- Triptorelin
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Infertility
GnRH Agonist and Progesterone Versus Progesterone Only for Luteal Phase Support in Antagonist Cycles
In-Vitro Fertilisation (IVF) is the term commonly applied to a form of treatment for infertility that involves controlled ovarian hyperstimulation, egg maturation, egg collection, fertilisation, embryo culture and finally embryo…
- Trial name
- GALA (NCT02262416)
- Testing
- leuprolide
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queensland Fertility Group
Pregnancy Early, Miscarriage
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Gonadotropin Releasing Hormone agonist (GnRHa) triggering is used as an alternative to human chorionic gonadotropin (hCG) in GnRH antagonist protocol to eliminate the risk of ovarian hyperstimulation syndrome (OHSS).
- Conditions
- Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
- Trial name
- NCT04797338
- Testing
- Synarel, 0.2 Mg/Inh Nasal Spray, Estrofem, Utrogestan
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Obesity, Maternal
The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Women
This study aims to explore whether the application of low-dose HCG in luteal support can improve the pregnancy outcomes of natural cycle frozen embryo transfer in obese patients
- Trial name
- NCT07633002
- Testing
- Human Chorionic Gonadotropin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
In Vitro Fertilization
Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support in Patients Undergoing In-Vitro Fertilization (IVF)
Prospective, open, randomised, parallel, multicentre, two arm trial comparing a new form of luteal support (S.C.) to an approved comparator (vaginal gel).
- Trial name
- NCT00827983
- Testing
- Progesterone
- Where
- 14 sites in Germany, Hungary and 3 more
- Volunteers
- 683 people
- Sponsor
- IBSA Institut Biochimique SA
Infertility
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.
- Trial name
- NCT01046708
- Testing
- micronized progesterone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
In Vitro Fertilization, Psychological Stress
Does Emotional Support Decrease In Vitro Fertilization Stress?
In vitro fertilization for infertility has been associated with a significant amount of treatment related stress for patients. In addition,stress levels increase between embryo transfer and pregnancy test, during this waiting…
- Trial name
- NCT01406028
- Testing
- Phone calls
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Brigham and Women's Hospital