Clinical trials: Luteal Support
Pregnancy, Progesterone Supplementation
Individualized Prolonged Luteal Support After Fresh Embryo Transfer in Women With Low Progesterone
The goal of this clinical trial is to compare live birth rate in a control group versus an interventional group in subjects aged 18 to 37, pregnant after a fresh embryo transfer and with a serum progesterone level below 17 ng/mL…
- Conditions
- Pregnancy, Progesterone Supplementation, Low Serum Progesterone
- Trial name
- ProLIS (NCT07613528)
- Testing
- Progesterone Injectable, Progesterone Vaginal Suppository
- Where
- France
- Volunteers
- 214 people
- Sponsor
- University Hospital, Montpellier
Subfertility
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the…
- Trial name
- NCT04064840
- Testing
- IVF: Decapeptyl and hCG, FET: Decapeptyl, IVF: hCG and normal saline
- Where
- China
- Volunteers
- 784 people
- Sponsor
- The University of Hong Kong
Infertility, Female, Frozen Embryo Transfer
Luteal Phase Support During Frozen Embryo Transfer Cycle
We aimed to decrease quantity of exogenous estrogen and evaluated the success rate of ongoing pregnancy in women undergone artificial FET who have a surplus embryos at previous fertility treatment cycles.
- Trial name
- NCT04013438
- Testing
- Strogen
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Subfertility
A Study of Human Chorionic Gonadotrophin as Luteal Phase Support in Frozen Embryo Transfer
A randomised trial on the use of luteal phase support in frozen-thawed embryo transfer cycles. The hypothesis of the study is that the use of luteal phase support with human chorionic gonadotrophin would increase the pregnancy…
- Trial name
- NCT01931384
- Testing
- Human chorionic gonadotrophin
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- The University of Hong Kong
GnRHa;LPS
Gonadotrophin Releasing Hormone Agonist Addition for Luteal Support in In-vitro Fertilization and Embryo Transfer Cycles
The study was designed to investigate the effect of luteal-phase administration of gonadotrophin releasing hormone agonist(GnRHa) on pregnancy outcomes in in-vitro fertilization-embryo transfer.
- Trial name
- NCT02908438
- Testing
- Gonadotrophin releasing hormone agonist(GnRHa)
- Volunteers
- 400 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Ivf, Frozen Embryo Transfer (FET)
Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone
Background: The capability to transfer frozen embryos reduces embryo loss following in vitro fertilization (IVF) and results in higher pregnancy rates compared to a single IVF cycle.
- Trial name
- NCT06870266
- Testing
- Nafarelin nasal spray, Utrogestan®
- Volunteers
- 150 people
- Sponsor
- Shaare Zedek Medical Center
Infertility, IVF
Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer
Randomized controlled study, open label to compare effectiveness of addition of dydrogesterone 20mg to the standard luteal phase support treatment after fresh embryos transfer.
- Trial name
- NCT04408144
- Testing
- Dydrogesterone 10mg Oral Tablet
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Pregnancy
Endometrial Injury Versus Luteal Phase Support in Intrauterine Insemination Cycles
The investigators will try to assess the effect of endometrial injury preceding the intrauterine insemination cycle on the pregnancy rates compared to cycles with luteal phase support and the control group.
- Trial name
- NCT02492451
- Testing
- Endometrial Injury, progesterone (Crinone® %8 vaginal progesterone gel)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Luteal Support, Frozen Embryo Transfer (FET)
Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles
Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product.
- Trial name
- NCT06875752
- Testing
- no luteal support, Vaginal Progesterone, Progesterone plus HCG
- Where
- 5 sites in Hungary
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Effect of Adding GnRHa as Luteal Phase Support in Antagonist ART Cycles
Role of Triptorelin 0.1 mg as a Luteal Phase Support in Assisted Reproductive Technique After Embryo Transfer : a Randomized Controlled Trial
There is still controversy over the best LPS agent and protocol and its dose and duration as well as the time of initiation and cessation.
- Trial name
- NCT04087408
- Testing
- Effect of adding gonadotropins releasing hormone agonist to progesterone for luteal phase support in assisted reproductive technique )antagonist cycles(: a randomized controlled trial
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Moustafa Mohammed Abouelea
Infertility, Female, Infertility, Male
Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles
The aim of this randomized controlled trial is to compare the efficacy of oral dydrogesterone vs. micronized vaginal progesterone for luteal phase support in frozen-thawed embryo transfer cycles.
- Conditions
- Infertility, Female, Infertility, Male, Embryo Transfer, Fertilization in Vitro
- Trial name
- NCT04124913
- Testing
- Dydrogesterone 10 MG Oral Tablet, Progesterone Vaginal Gel [Crinone]
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Memorial Sisli Hospital, Istanbul
Infertility
GnRH Agonist as Luteal Support in FET Cycles
Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.
- Trial name
- NCT02620124
- Testing
- Natural cycle: Triptorelin acetate 0.1 mg, Hormone replacement cycle and triptorelin acetate 0.1 mg
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Infertility
the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer .
The aim of the present prospective randomized controlled study was to determine the effects of GnRHa add up to routine luteal phase support on frozen embryo implantation in frozen embryo transfer (FET).
- Trial name
- NCT02655146
- Testing
- triptorelin 0.1, E2, Progesterone
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Chong Qing Reproducive and Genetic Institute
Pregnancy
Effect of Luteal Progesterone Support on Pregnancy Rates With Combined Clomid/ Gonadotropin & IUI
To determine the difference in clinical pregnancy rates with and without luteal progesterone support in a young reproductive aged population having undergone ovulation induction with combined clomiphene citrate and gonadotropin…
- Trial name
- NCT02510534
- Testing
- Menopur 150 international units, Endometrin 100 mg
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Infertility and Reproductive Endocrinology
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Endometrial Receptivity
Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
Both controlled ovarian stimulation (COS) and frozen embryo transfer has become an integral part of in vitro fertilization (IVF) treatment.
- Trial name
- HormoSenoRec (NCT06280560)
- Testing
- Controlled Ovarian Stimulation + Luteal Phase Support, Hormonal Replacement Therapy programmed artificial cycle, Natural Cycle (NC)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundación IVI
Infertility
Intrauterine Insemination and Luteal Fase Support
The objective is to test the hypothesis that luteal phase support with vaginal progesterone leads to a higher clinical pregnancy rate (primary outcome) and live birth rate (secondary outcome) when compared to no luteal phase…
- Trial name
- NCT01826747
- Testing
- crinone (progesterone 8%, vaginal application)
- Where
- Belgium
- Volunteers
- 393 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Frozen Embryo Transfer, Hormone Replacement Therapy
Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles
To investigate the efficacy of dydrogesterone 30 mg compared to micronized vaginal progesterone 800 mg daily for luteal phase support in hormone replacement therapy frozen embryo transfer cycles, as confirmed by visualization of…
- Conditions
- Frozen Embryo Transfer, Hormone Replacement Therapy, Dydrogesterone, Infertility, Female
- Trial name
- REMODEL (NCT04758871)
- Testing
- Dydrogesterone 10 MG Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- CRG UZ Brussel
In Vitro Fertilization
Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF)
Prospective, open, randomized, parallel, multicenter, two-arm trial to evaluate the efficacy and tolerability of a new progesterone formulation to be used for luteal support in IVF (Progesterone-IBSA) administered subcutaneously…
- Trial name
- NCT00828191
- Testing
- Progesterone
- Where
- 8 sites in United States
- Volunteers
- 800 people
- Sponsor
- IBSA Institut Biochimique SA