Clinical trials: Lymph Node
Esophageal Cancer, Sentinel Lymph Node
The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy
Sentinel lymph nodes, as the primary site of tumor metastasis, play a pivotal role in assessing patient prognosis and planning subsequent treatment strategies.
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green
- Trial name
- NCT07303231
- Testing
- Minimally invasive surgery for esophageal cancer using near-infrared indocyanine green fluorescence to visualize the sentinel lymph node
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Breast Cancer, Melanoma
Second Echelon Node Study With Methylene Blue
The investigators plan to study the ability to identify the lymph nodes beyond the sentinel lymph node that may harbor cancer using methylene blue dye.
- Trial name
- NCT01823172
- Testing
- Methylene blue dye injection of sentinel lymph node
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Prostate or Bladder Cancer
Effect of TachoSil® on Incidence of Symptomatic and Radiographic Lymphoceles After Extended Pelvic Lymph Node Dissection in Prostate and Bladder Cancer.
Pelvic lymph node dissection (PLND) is the most accurate staging tool to determine lymph node involvement in prostate and bladder cancer.
- Trial name
- NCT02001857
- Testing
- 1 TachoSil hemostatic sponge (9,5 cm x 4,8 cm) placed on each side on the external iliac artery.
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Prostatic Neoplasms, Lymphatic Metastasis
MR-Lymphography and Lymph Node Staging in Prostate Cancer
This proposal is targeted at all patients with prostate cancer who are candidates for either curative surgery or curative radiotherapy in whom lymph node staging is indicated.
- Trial name
- NCT00185029
- Testing
- Ferumoxtran-10 enhanced MRI (MRL)
- Where
- 3 sites in Netherlands
- Volunteers
- 396 people
- Sponsor
- Radboud University Medical Center
Oligometastatic Hormone-Sensitive Prostate Cancer, Prostate Adenocarcinoma
Prospective Study on the Role of Radical Prostatectomy in Oligo-metastatic Hormone-sensitive Prostate Cancer in Patients on Androgen Deprivation Therapy
MAZINGA is a prospective, single-group pilot study evaluating disease control after robot-assisted radical prostatectomy with extended pelvic lymph-node dissection in men with oligometastatic hormone-sensitive prostate…
- Trial name
- MAZINGA (NCT07766486)
- Testing
- Robot-Assisted Radical Prostatectomy With Extended Pelvic Lymph-Node Dissection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Stage I Adrenal Cortical Carcinoma AJCC v7, Stage II Adrenal Cortical Carcinoma AJCC v7
Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor
This phase III clinical trial is studying how well cisplatin-based chemotherapy and/or surgery works in treating young patients with stage I, stage II, stage III or stage IV adrenocortical cancer.
- Conditions
- Stage I Adrenal Cortical Carcinoma AJCC v7, Stage II Adrenal Cortical Carcinoma AJCC v7, Stage III Adrenal Cortical Carcinoma AJCC v7, Stage IV Adrenal Cortical Carcinoma AJCC v7
- Trial name
- NCT00304070
- Testing
- Cisplatin, Conventional Surgery, Doxorubicin Hydrochloride
- Where
- 91 sites in United States, Australia and 2 more
- Volunteers
- 78 people
- Sponsor
- Children's Oncology Group
Cervical Cancers
A Clinical Study Comparing Chemotherapy Combined With PD-1 Inhibitor Versus Concurrent Chemoradiotherapy in Cervical Cancer Patients With Positive Lymph Nodes After Surgery: A Multicenter Randomized Controlled Clinical Trial
This study aims to conduct a prospective, multicenter, randomized controlled trial targeting patients with cervical cancer who have been pathologically confirmed to have lymph node metastasis after surgery.
- Trial name
- NCT06866951
- Testing
- Chemo-immunotherapy, CCRT
- Where
- China
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Prostate Cancer
Dose Optimization and Diagnostic Performance in Prostate Cancer (SPARROW [Staging Prostate Cancer With Advanced RM2 Radiotracer Oncologic Workup])
This is an open-label, nonrandomized, multicenter study conducted in two sequential parts: an initial Phase 2 Dose Optimization Period followed by the Phase 3 Diagnostic Performance Period.
- Trial name
- SPARROW (NCT07831824)
- Testing
- [68Ga]-LNTH-2401
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- Lantheus Medical Imaging
Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS)
Sirolimus for Autoimmune Disease of Blood Cells
Treatment for patients with autoimmune destruction of blood cells is poor. The part of the body that fights infections is called the immune system and white blood cells (WBCs) are part of the immune system.
- Conditions
- Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS), Evans Syndrome, Idiopathic Thrombocytopenic Purpura
- Trial name
- NCT00392951
- Testing
- sirolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Head and Neck Squamous Cell Carcinoma HNSCC
[68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
The trial focuses on assessing the role of [68Ga]Ga-FAPI-46 in head and neck squamous cell carcinomas (HNSCC) staging before surgery.
- Trial name
- FAPIHN (NCT06794372)
- Testing
- [68Ga]Ga-FAPI-46 PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- John O. Prior
HIV/AIDS
Reducing HIV Persistence in Lymph Nodes by Interleukin-15 (IL-15) Receptor Super-agonist (N-803) in Acute HIV Infection
Reducing HIV persistence in lymph nodes by Interleukin-15 (IL-15) Receptor super-agonist (N-803) in Individuals with Acute HIV Infection
- Trial name
- NCT04505501
- Testing
- N-803
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Thai Red Cross AIDS Research Centre
Prostatic Neoplasms Benign, Radiotherapy Side Effect
Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis
Men with high risk prostate cancer who underwent radiotherapy of the prostate/seminal vesicles or underwent postoperative radiotherapy including pelvic lymph nodes between 2010 and 2016 are analyzed retrospectively.
- Conditions
- Prostatic Neoplasms Benign, Radiotherapy Side Effect, Lymph Node Disease
- Trial name
- NCT02998619
- Testing
- Radiotherapy
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Kantonsspital Graubünden
Melanoma
Excision of Lymph Node Trial (EXCILYNT) (Mel69)
The purpose of this study is to find out if removing only the cancerous lymph node (known as a lymph node excision) is effective at preventing cancer from coming back in the same area of the lymph node excision.
- Trial name
- EXCILYNT (NCT05839912)
- Testing
- Excision of clinically detected lymph node metastasis before any systemic therapy, Excision of clinically detected lymph node metastasis after neoadjuvant systemic therapy
- Where
- 7 sites in United States
- Volunteers
- 66 people
- Sponsor
- Craig L Slingluff, Jr
Locally Advanced Cervical Cancer
Predictors of Para-aortic Lymph Node Metastasis of Cervical Cancer
The goal of this observational study is to identify predictive factors and to develop a risk model predicting para-aortic lymph node metastasis in patients with locally advanced cervical cancer based on the analysis of surgical…
- Trial name
- NCT05717751
- Testing
- surgical staging
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Chongqing University Cancer Hospital
Detection Rate of SLN ; Accuracy Rate of Lymph Node Metastasis
Sentinel Lymph Node Navigation Surgery Using Near-infrared Imaging in Early Esophageal Cancer
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Trial name
- NCT04173676
- Testing
- Indocyanine Green for Injection
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Breast Cancer
Technetium Tc 99m Sulfur Colloid and Blue Dye In Detecting Sentinel Lymph Nodes in Patients With Breast Cancer
RATIONALE: It is not yet known whether injecting technetium Tc 99m sulfur colloid and blue dye near the tumor is more effective than injecting them near the nipple in identifying sentinel lymph nodes in patients with stage I or…
- Trial name
- NCT00052676
- Testing
- patent blue V dye, radionuclide imaging, sentinel lymph node biopsy
- Where
- 7 sites in France
- Sponsor
- Centre Paul Strauss
Breast Cancer
T1-T2 Breast Cancer: Comparison Between Removal and Preservation of Axillary Lymph Nodes (SINODAR ONE)
Italian Multicentric non inferiority two-arm randomized clinical trial to verify that the experimental treatment (omission of axillary lymph node intervention) in the presence of sentinel lymph node metastases does not lead to a…
- Trial name
- SINODAR ONE (NCT05160324)
- Testing
- Removal of axillary lymph nodes., Preservation of axillary lymph nodes
- Volunteers
- 889 people
- Sponsor
- Fondazione Humanitas per la Ricerca
Head and Neck Cancer
Lymph Drainage Mapping for Tailoring Elective Nodal Irradiation in Head and Neck Cancer
This study aims to explore the safety and outcome of lymph drainage mapping(LDM) to individually tailor the elective nodal irradiation (ENI) to the ipsilateral neck only.
- Trial name
- SUSPECT-2 (NCT03968679)
- Testing
- Unilateral elective nodal irradiation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Rectal Cancer Stage III, Rectal Cancer Stage IV
Sentinel Lymph Node Biopsy in Rectal Cancer
Rectal cancer is one of the most common malignant tumors, with 9% to 23% of patients experiencing pelvic sidewall lymph node metastasis.
- Trial name
- NCT05830890
- Testing
- Sentinel lymph node biopsy, Indocyanine green solution, fluorescence laparoscope
- Where
- China
- Volunteers
- 87 people
- Sponsor
- National Cancer Center, China
Alzheimer s Disease
Efficacy of Lymphatic-Venous Anastomosis Plus Donepezil Versus Donepezil Alone for Alzheimer's Disease
This study employed a multicenter, randomized controlled trial (RCT) design to evaluate the efficacy and safety of deep cervical lymphatic/lymph node-venous anastomosis combined with oral donepezil compared to donepezil…
- Trial name
- NCT07680660
- Testing
- Cervical lymph vessel/node-venous anastomosis surgery combined with oral donepezil, Oral treatment with donepezil
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
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