Clinical trials: Lymph Node
Melanoma
Complete Lymph Node Dissection vs Watchful Waiting in Patients With Malignant Melanoma (Thickness of 1,0mm+ and Evidence of Metastases in the Sentinel Node)
Sentinel lymph node biopsy (SLNB) is considered as standard diagnostic procedure in melanoma patients carrying a reasonable risk for metastases.
- Trial name
- DeCOG-SLT (NCT02434107)
- Testing
- Completion Lymphadenectomy, Clinical Monitoring (Palpation and node ultrasound)
- Where
- 41 sites in Germany
- Volunteers
- 483 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer
Efficacy and Safety Of Xeloda as Sequential Adjuvant Therapy After Chemotherapy in Breast Cancer
Select 600 cases of women with breast cancer of triple negative or Her-2 positive or with more than 4 axillary lymph node metastasis. All the patients were accepted the chemotherapy of Anthracycline and/or Taxane.
- Trial name
- NCT01662128
- Testing
- Xeloda
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Tianjin Medical University
Gastric Cancer After D2 Lymph Node Dissection
Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection
Gastric cancer radical surgery related complications are common.Somatostatin is a conventional medical therapy for bleeding.This study explore the effect of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node dissection.
- Trial name
- NCT01914692
- Testing
- Somatostatin
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Cervical Cancer, Adjuvant Chemotherapy
A Trial Comparing Adjuvant Chemotherapy With Observation After Concurrent Chemoradiotherapy of Cervical Cancer (With Pelvic or Para-aortic Node Involvement)
Cervical cancer with pelvic or para-aortic node involvement has a poor prognosis. Despite low-quality data, the routine practice to treat these patients is radiation with concurrent cisplatin.
- Conditions
- Cervical Cancer, Adjuvant Chemotherapy, Radiation, Lymph Node Metastases
- Trial name
- NCT03468010
- Testing
- chemoradiation, Paclitaxel, Cisplatin
- Where
- 8 sites in China
- Volunteers
- 432 people
- Sponsor
- Sun Yat-sen University
Prostatic Neoplasms, Lymphatic Metastasis
MR-Lymphography and Lymph Node Staging in Prostate Cancer
This proposal is targeted at all patients with prostate cancer who are candidates for either curative surgery or curative radiotherapy in whom lymph node staging is indicated.
- Trial name
- NCT00185029
- Testing
- Ferumoxtran-10 enhanced MRI (MRL)
- Where
- 3 sites in Netherlands
- Volunteers
- 396 people
- Sponsor
- Radboud University Medical Center
Non-Small Cell Lung Cancer
Station 4L Lymph Node Dissection Versus No Dissection in Clinical Stage I Solid Nodule-Type Invasive NSCLC
This multicenter, prospective, randomized clinical trial will enroll adults aged 18 to 75 years with resectable clinical stage I (T1-T2aN0M0) invasive non-small cell lung cancer presenting as a single solid nodule…
- Trial name
- NCT07801430
- Testing
- Station 4L Lymph Node Dissection
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Fudan University
Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8
Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial
This phase II trial studies how well personalized neck radiation therapy directed by sentinel lymph node biopsy (SLNB) works in treating patients with oral cavity squamous cell carcinoma (OCSCC).
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8, Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8
- Trial name
- NCT07121595
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan Rogel Cancer Center
Melanoma, Head and Neck Cancer
Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes
The aim of this study is to investigate whether the Sentinella camera improves intraoperative detection and removal of sentinel lymph nodes (SLNs) when used in conjunction with standard detection methods.
- Conditions
- Melanoma, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02416336
- Testing
- Sentinella Intraoperative imaging protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oncovision Inc
Prostate Cancer, Lymph Node Metastases
Accuracy of Lymph Node Imaging in Prostate Cancer: PSMA PET-CT and Nano-MRI
Following curative intended therapy in prostate cancer patients, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence.
- Trial name
- MAGNIFY (NCT03223064)
- Testing
- Ferumoxtran-10 enhanced MRI; MRI contrast agent, 68Ga PSMA PET-CT
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation
The aim of this study is to assess the outcomes of breast conserving therapy operation depending on the type of surgical tool used: classic electrocoagulation with higher operative temperatures and high frequency…
- Trial name
- NCT01216254
- Testing
- classic v high-frequency electrocoagulation
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Prostate Cancer
Evaluation of the SENSEI® Laparoscopic Tethered Gamma Probe for 99mTc-nanocolloid Sentinel Lymph Node Biopsy in Prostate Cancer
This study is a prospective, open label, single-arm study to examine the performance and safety of the SENSEI® laparoscopic tethered gamma probe in patients undergoing 99mTc-nanocolloid SLNB for prostate cancer (PCa) during RP…
- Trial name
- LPM-012 (NCT04632251)
- Testing
- SENSEI®
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 56 people
- Sponsor
- Lightpoint Medical Limited
Prostate Cancer Metastatic Disease, Oligometastatic Prostate Cancer (OMPC)
HIghly MetAstatic Life Prolonging Therapy-Resistant Prostate Cancer: Role of Stereotactic Radiotherapy for Bone and Lymph Node Metastases (HIMARS)
The investigators propose redefining this concept by focusing on volume rather than the number of metastases. To achieve this, the investigators aim to determine the Maximum Tolerated Volume (MTV) of metastatic lesions treatable…
- Trial name
- HIMARS (NCT06978296)
- Testing
- Stereotactic body radiotherapy (SBRT)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Sentinel Lymph Node Biopsy Versus no Axillary Surgery in Early Breast Cancer
The VENUS trial is a prospective, multicenter, noninferiority, randomized, controlled clinical trial that compares sentinel lymph node biopsy versus no axillary surgery in women with early breast cancer (tumor <5cm) and…
- Trial name
- VENUS (NCT05315154)
- Testing
- No axillary surgery, SLNB
- Where
- 18 sites in Brazil
- Volunteers
- 800 people
- Sponsor
- University of Campinas, Brazil
Breast Cancer
OPTimizing Irradiation Through Molecular Assesment of Lymph Node After Primary Systemic Treatment
Breast cancer management integrating surgery, systemic therapy and radiation therapy tends to systemic treatment as the first therapeutic option, continuing afterwards by surgery and radiation therapy with the scope of decreasing…
- Trial name
- OPTIMALIIa (NCT03972696)
- Testing
- Irradiation
- Where
- 20 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia
Bladder Urothelial Carcinoma, Lymph Node Metastasis
Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC
This is a prospective, multicenter, Phase Ib clinical study designed to evaluate the safety and preliminary efficacy of propranolol combined with tislelizumab plus gemcitabine/cisplatin (GC) as neoadjuvant therapy for patients…
- Trial name
- NCT07353294
- Testing
- propranolol, Tislelizumab, gemcitabine
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Surgery
Medico-economic Study of Three Strategies of Sentinel Lymph Node Analysis in Operable Breast Cancer
Breast carcinoma requires frequently an adjuvant therapy after surgical excision: in this way, one of the major criteria indicating the need of adjuvant chemotherapy is the diagnosis of a metastatic lymph-node invasion, mainly in…
- Trial name
- SAGE (NCT02056886)
- Testing
- SLN detection +/- complementary axillary lymphadenectomy
- Where
- 17 sites in France
- Volunteers
- 858 people
- Sponsor
- Institut Cancerologie de l'Ouest
Prostate Cancer, Oligometastasis
Comparison of Intermittent Androgen Deprivation Therapy With or Without Irradiation Recovery in Prostate Cancer Patients
Metastatic prostate cancer has traditionally been regarded as an incurable dissemination of disease, and treatment is focused on delaying progression rather than eliminating all tumor burden.
- Trial name
- OLIGOPELVIS2 (NCT03630666)
- Testing
- IADT, IADT + radiotherapy
- Where
- 16 sites in France
- Volunteers
- 256 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer, Chemotherapy
ALND vs ART in Positive Sentinel Node After Neoadjuvant Therapy in Breast Cancer
In the case of primary surgery, in patients with sentinel node involvement, it has already been shown that omitting axillary lymph node dissection (ALND), often combining axillary radiotherapy (RT), does not worsen the prognosis…
- Conditions
- Breast Cancer, Chemotherapy, Sentinel Lymph Node, Axillary Lymph Nodes Dissection
- Trial name
- ADARNAT (NCT04889924)
- Testing
- Axillary Radiotherapy, Lymphadenectomy
- Where
- 61 sites in Australia, Spain
- Volunteers
- 820 people
- Sponsor
- Hospital Universitari de Bellvitge
Mediastinal Lymph Node Enlargement, Sarcoidosis
Bronchoscopic Sampling Techniques in Sarcoidosis
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal lymph node (MLN) sampling.
- Conditions
- Mediastinal Lymph Node Enlargement, Sarcoidosis, Tuberculosis, Lymphomas
- Trial name
- NCT01836822
- Testing
- EBUS guided transbronchial forceps biopsy (EBUS-TBFB), EBUS guided transbronchial needle aspiration (EBUS-TBNA), large bore (19G) histologic needle biopsy of the mediastinal lymph nodes
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Warsaw
Melanoma
Nuclear and Near-Infrared (NIR) Imaging in Melanoma
Objectives: 1. To determine the feasibility of using microdose amounts of near-infrared (NIR) fluorescent contrast agent to image tumor-draining and contralateral lymphatics in melanoma patients prior to standard-of-care sentinel…
- Trial name
- NCT01295931
- Testing
- Indocyanine Green (IC-Green), Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
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