Clinical trials: Lymph Node
Breast Cancer
Characterizing Breast Cancer With 68Ga-FAPI PET/CT (PFB-01)
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts (CAFs), which constitute a major proportion of cells within the tumor microenvironment, especially in breast cancer.
- Trial name
- NCT05574907
- Testing
- 68Ga-FAPI PET/CT scan
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer
The Value of Preoperative Sentinel Lymph Node Mapping by Pelvic MR Lymphangiography and SPECT-CT in Cervical Cancer
Objective of the study: To study the concordance of sentinel node (SN) localization between preoperative Magnetic Resonance Lymphangiography and SPECT-CT SN mapping and the intra-operative SN procedure for low stage cervical…
- Trial name
- NCT01777230
- Testing
- SPECT-CT sentinel node mapping, Magnetic Resonance Lymphangiography sentinel node mapping, Intra-operative sentinel node procedure
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Sentinel Lymph Node, Ovarian Cancer Stage I
SEntine Lymph Node in earLY Ovarian Cancer (SELLY)
The present study aims at investigating the feasibility, the detection rate and the negative predictive value of sentinel node in predicting the presence or absence of lymph node metastasis in ovarian cancer patients
- Trial name
- SELLY (NCT03563781)
- Testing
- Sentinel node detection
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metastatic Cancer
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates
Stereotactic ablative body radiotherapy (SABR) can be considered for patients with so-called "oligometastatic" disease. However, since this is a relatively new technique, information on the optimal scheduling is lacking.
- Trial name
- Destroy (NCT03486431)
- Testing
- Stereotactic Ablative Radiotherapy (SABR)
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Cancer Research Antwerp
Gastric Cancer
Identification of Complete Lymph Node Removal by Application of Near Infrared Fluorescence Imaging in Laparoscopic and Robotic Gastrectomy
Lymph node dissection in gastric cancer surgery is a very important factor not only for exact acquisition of stage but also proper treatment.
- Trial name
- NCT01926743
- Testing
- Near infrared fluorescence imaging during laparoscopic or robotic gastrectomy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Breast Neoplasms
ICG and Blue Dye Guided Sentinel Lymph Node Biopsy in Patients Underwent Neoadjuvant Therapy
The value of sentinel lymph node biopsy (SLNB) in patients underwent neoadjuvant chemotherapy is controversial. Lower detection rate and higher false negative rate are the main problem.
- Trial name
- NCT02869815
- Testing
- ICG+Methylene Blue
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Lymph Node Metastasis, Gynecologic Cancer
Image-guided Ultrasound Robotic Intraoperative Evaluation of Lymph-nodes Status in Gynecological Malignancies
The assessment of lymph node status is of crucial importance in gynaecological malignancies. Indeed, the prognosis and adjuvant treatment regimens are strongly influenced by the presence of nodal involvement.
- Trial name
- R-LYNUS (NCT06621823)
- Testing
- image-guided surgery technique
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stomach Neoplasms, Cancer of Lymph Node
Lymph Node Metastasis in Extended Lymphadenectomy for Gastric Cancer From a CLASSIC Trial
The pattern of lymph node metastasis of the gastric cancer to each geographic lymph nose stations and the relation between each metastasis and survival are to be analyzed by retrospective review of medical records of who enrolled…
- Trial name
- NCT02298010
- Testing
- Capecitabine, oxaliplatin
- Volunteers
- 899 people
- Sponsor
- Seoul National University Hospital
Head and Neck Neoplasms, Recurrence Tumor
Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment
The aim of the study is to determine the feasibility and efficacy of moderate weekly whole Body hyperthermia Treatment during radiochemotherapy for pre-irradiated locally or regionally recurrent head and neck squamous cell…
- Trial name
- GKH-TMM (NCT03547388)
- Testing
- Moderate whole body hyperthermia using water-filtered IR-A-radiation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Non-Small Cell Lung Cancer, Lymph Node Metastasis
XR-Assisted PET/CT Navigation for Cervical Lymph Node Dissection in Lung Cancer
This single-arm, prospective feasibility study evaluates an Extended Reality (XR) headset-based preoperative surgical planning workflow that fuses 18F-FDG PET metabolic hotspots with CT anatomy on the OpVerse platform, in…
- Conditions
- Non-Small Cell Lung Cancer, Lymph Node Metastasis, Supraclavicular Lymph Node Metastasis
- Trial name
- XR-NeckLND (NCT07593872)
- Testing
- OpVerse XR Surgical Planning Platform with HoloLens HMD, Cervical / Supraclavicular Lymph Node Dissection
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Invasive Breast Cancer
Axillary Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
Data from cohorts, prospective studies and one randomized trial (ASCOG Z0011) support the hypothesis that omission of additional axillary dissection in case of positive sentinel node has a limited impact on overall survival and…
- Trial name
- NCT01717131
- Testing
- Surgery for standard axillary node dissection, No axillary lymph node dissection
- Where
- France
- Volunteers
- 2,228 people
- Sponsor
- Institut Paoli-Calmettes
Rectal Cancer
Low or High Ligation of the IMA With Apical Lymph Node Dissection in Rectal Cancer Laparoscopic Surgery
Laparoscopy colon surgery is accepted worldwide in the recent years. But there is still argument on the effect of laparoscopy rectal surgery.
- Trial name
- NCT03013153
- Testing
- Low ligation with apical lymph node dissection, High ligation
- Where
- China
- Volunteers
- 748 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Sentinel Lymph Node, Breast Cancers
EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast Cancers
For early breast cancer patients, breast-conserving surgery and sentinel lymph node biopsy have emerged as the cornerstone of precision oncology, harmonizing oncologic efficacy with the preservation of breast cosmetics and…
- Conditions
- Sentinel Lymph Node, Breast Cancers, Metastases, Margin Assessment
- Trial name
- NCT07018505
- Testing
- SERS detection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
Adenocarcinoma of the Prostate
Single Photon Emission Computed Tomography (SPECT) Lymph Node Mapping
The purpose of this study is to determine if the planning of radiation treatment of prostate cancer patient can be made more precise by comparing currently planning techniques to an imaging technique called SPECT.
- Trial name
- SPECT (NCT00608920)
- Testing
- Single Photon Emission Computed Tomography (SPECT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Non Small Cell Lung Cancer
Preoperative Lymph Node Staging With EBUS-TBNA in Clinical N0 Non Small-cell Lung Cancer
The introduction of modern staging systems has increased the detection of small peripheral lung cancers at an early stage [1]. Stage I non-small-cell lung cancers (NSCLCs) are confined to the lung without lymph node involvement…
- Trial name
- NCT04828850
- Testing
- Endobronchial ultrasound transbronchial needle aspiration lymph node staging
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Cervical Cancer, Lymph Node Metastasis
Development of an Imaging Prediction Model for Pelvic Lymph Node Metastasis of Cervical Cancer Using Artificial Intelligence Techniques.
This study is a retrospective exploratory trial conducted at a single center, aiming to develop and validate a preoperative lymphatic metastasis model for cervical cancer using artificial intelligence deep learning.
- Conditions
- Cervical Cancer, Lymph Node Metastasis, Artificial Intelligence
- Trial name
- NCT06448897
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Bladder Urothelial Carcinoma, Stage III Bladder Cancer AJCC v8
A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
This phase II trial studies the benefit of adding an immunotherapy drug called MEDI4736 (durvalumab) to standard chemotherapy and radiation therapy in treating bladder cancer which has spread to the lymph nodes.
- Trial name
- NCT04216290
- Testing
- Biopsy of Bladder, Biospecimen Collection, Cisplatin
- Where
- 216 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
ESCC, Adjuvant Treatment
Pembrolizumab in Post Radical Operation ESCC Patients With Lymph Node Positive ( KEYSTONE-004 )
The purpose of this study is to observe and evaluate the efficacy and safety of postoperative adjuvant treatment of pembrolizumab in patients with thoracic esophageal squamous cell carcinoma （ESCC） who have not received…
- Conditions
- ESCC, Adjuvant Treatment, Lymph Node Positive, Pembrolizumab
- Trial name
- NCT04863079
- Testing
- Pembrolizumab Injection [Keytruda]
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Lymphedema
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection
This randomized phase III trial studies how well education with or without physical therapy intervention works in preventing lymphedema in women with stage I, II, or III breast cancer who are undergoing axillary lymph node…
- Trial name
- NCT00376597
- Testing
- quality of life assessment, educational intervention, Physical therapy
- Where
- 76 sites in United States
- Sponsor
- Alliance for Clinical Trials in Oncology
Kawasaki Disease, Children
Anakinra and Kawasaki Disease
The study is designed to assess the efficacy and safety of anakinra, an interleukin 1 receptor antagonist, in patients with Kawasaki disease who failed to respond to standard treatment:e.g.
- Trial name
- KAWAKINRA (NCT02390596)
- Testing
- Anakinra
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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