Clinical trials: Lymph Node
Rehabilitation
Early and Systematic Shoulder Rehabilitation Following Cervical Lymph Node Dissection
A prospective, monocentric, controlled, randomized study of systematic early shoulder rehabilitation following cervical lymph node dissection for the prevention and treatment of shoulder dysfunction.
- Trial name
- RESYSTE (NCT03961802)
- Testing
- sessions of shoulder rehabilitation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Nantes University Hospital
Breast Cancer Invasive
Diagnostic Performance of [18F]FES PET/CT for Axillary LN Metastasis in ER-positive Breast Cancer
This study aims to explore the diagnostic performance of [18F]FES PET/CT for the evaluation of axillary lymph node metastasis in patients with ER-positive breast cancer having clinically suspected or confirmed axillary lymph node…
- Trial name
- NCT06695039
- Testing
- Fluoroestradiol (18F)
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Asan Medical Center
HIV Infections
A Study of AL721 in HIV-Infected Patients With Swollen Lymph Nodes
To study the tolerance and safety of increasing doses of AL-721 in patients with persistent generalized lymphadenopathy (PGL) and symptomatic HIV infection, and to obtain preliminary information on the effectiveness of AL-721…
- Trial name
- NCT00001012
- Testing
- AL 721
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Neoplasms, Radiotherapy
Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions
The goal of this trial is to evaluate the effect of the prone crawl treatment position and/or accelerated schedule on acute and late toxicities, as well as quality of life and time management for breast cancer patients receiving…
- Conditions
- Breast Neoplasms, Radiotherapy, Lymph Node Metastases
- Trial name
- PRO-SURF (NCT03280719)
- Testing
- Prone Radiotherapy, Acceleration, Supine Radiotherapy
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Ghent
Pancreatic Neoplasm, Neoplasm of Intra-abdominal Lymph Nodes
Prospective Study Comparing Methods of Obtainment of Specimen After EUS-FNA in Patients With Peri-pancreatic Mass
EUS-guided FNA has been proved to be a safe and useful method for tissue sampling of gastrointestinal track lesions and other organ lesions including mediastinal and intra-abdominal lymph nodes, pancreas and hepatobiliary tree.
- Trial name
- EUS-FNA (NCT01354795)
- Testing
- 1.EUS-FNA with or without suction, 2.Pushing the stylet or injecting air
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Secondary Lymphedema
Clinical Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema (AdeLE)
This study evaluates the efficacy of Lymfactin® in patients with secondary lymphedema associated with the treatment of breast cancer by comparing the effects of active study treatment Lymfactin® to placebo.
- Trial name
- AdeLE (NCT03658967)
- Testing
- Lymfactin® (1x10E11 vp)
- Where
- 5 sites in Finland, Sweden
- Volunteers
- 39 people
- Sponsor
- Herantis Pharma Plc.
Metastatic Cancer, Soft Tissue Sarcoma
A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors
This is a Phase I/IIa, multicenter, open-label, consecutive cohorts, dose-escalation study of BT-001 with repeated IT administrations alone and in combination with IV infusions of pembrolizumab.
- Conditions
- Metastatic Cancer, Soft Tissue Sarcoma, Merkel Cell Carcinoma, Melanoma
- Trial name
- NCT04725331
- Testing
- BT-001, Pembrolizumab [KEYTRUDA®]
- Where
- 5 sites in Belgium, France
- Volunteers
- 31 people
- Sponsor
- Transgene
Inguinal Lymph Nodes Enlarged
The Analgesic Efficacy of Ultrasound Guided Transversalis Fascia Plane Block in Inguinal Lymph Node Dissection
Pain accompanying Inguinal lymph node dissection triggers a complex stress response leading to impairment of pulmonary, immunological and metabolic function.
- Trial name
- NCT07331129
- Testing
- transversalis fascia plane block and surgical sit local anesthetic infiltration
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Esophageal Cancer, Sentinel Lymph Node
The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy
Sentinel lymph nodes, as the primary site of tumor metastasis, play a pivotal role in assessing patient prognosis and planning subsequent treatment strategies.
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green
- Trial name
- NCT07303231
- Testing
- Minimally invasive surgery for esophageal cancer using near-infrared indocyanine green fluorescence to visualize the sentinel lymph node
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Anatomical Description
Study of the Brain's Natural Cleaning System in Potential Organ Donors.
Alzheimer's disease is a condition that affects the brain and is associated with the build-up of waste substances that can damage brain cells.
- Trial name
- ICGBRAIN (NCT07682155)
- Testing
- Indocynanine Green meningeal injection to understand anatomical connection from the meningeal lymphatic system to the cervical lymph nodes
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Right Hemicolectomy
Fluorescence Lymph Node Mapping for Colon Cancer Surgery
Fluorescence-guided surgery using indocyanine green can visualize the complex and diverse lymph node drainage structures for each patient and help determine the extent of dissection of the D3 lymph node tailored to the patient.
- Trial name
- CONSTELLARE (NCT07060443)
- Testing
- Indocyanine green (ICG) injection for intraoperative lymph node imaging, Standard Right Hemicolectomy (Non-ICG)
- Where
- 13 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Pusan National University Yangsan Hospital
Breast Cancer
Sentinel Lymph Node Biopsy in Patients With Breast Cancer After Neoadjuvant Therapy
The aim of this study is to create clear indications for Sentinel Lymph Node Biopsy (SLNB) or Axillary Dissection (AD) in women with breast carcinoma after neoadjuvant therapy by studying the false negative rate of SLNB.
- Trial name
- NCT03556397
- Testing
- Sentinel lymph node biopsy (SLNB), Axillary dissection
- Where
- 2 sites in Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
NSCLC (Advanced Non-small Cell Lung Cancer), Post Surgical
Radiotherapy Plus Anti-PD-1 Versus Anti-PD-1 Alone in ypTanyN⁺M0 NSCLC
Patients with stage III non-small-cell lung cancer (NSCLC) who receive neoadjuvant chemoimmunotherapy may achieve good response in the primary tumor but still have residual nodal disease after surgery (ypTanyN⁺M0), which is…
- Trial name
- NCT07353476
- Testing
- radiotherapy, PD -1/PD-L1 monoclonal antibody
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
Melanoma
Multicenter Selective Lymphadenectomy Trial II (MSLT-II)
Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study requirements, the subject is randomized to receive either (1) completion…
- Trial name
- NCT00297895
- Testing
- Completion Lymphadenectomy, Monitoring with nodal ultrasound
- Where
- 63 sites in United States, Australia and 10 more
- Volunteers
- 1,939 people
- Sponsor
- Saint John's Cancer Institute
Lung Cancer
Significance of Ultrasound Elastography in Lymph Node
Background and Objectives: Elastography can reflect the difference of tissue hardness, which helps to identify the difference of hardness between benign and malignant tissues.
- Trial name
- NCT03391557
- Testing
- UE
- Volunteers
- 42 people
- Sponsor
- Fangsurong
Breast Cancer, Lymph Node Metastasis
Serum and Tissue Metabolite-based Prediction of Sentinel Lymph Node Metastasis in Breast Cancer
Breast cancer is a malignant tumor with the highest morbidity and mortality among women worldwide. Accurate staging of axillary lymph nodes is critical for metastatic assessment and decisions regarding treatment modalities in…
- Trial name
- NCT06001528
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Shantou Central Hospital
Breast Cancer
Multimodal Imaging Evaluation System of Axillary Lymph Node Staging and Treatment Strategy for Breast Cancer Neoadjuvant Therapy
In view of the lack of systematic curative effect prediction and early evaluation indicators for breast cancer neoadjuvant chemotherapy, the effective fusion of CEUS（contrast-enhanced ultrasound） and MRI is realized, and a…
- Trial name
- MIES-BCNAT (NCT04661436)
- Testing
- Contrast-Enhanced Ultrasound
- Volunteers
- 300 people
- Sponsor
- Sichuan Provincial People's Hospital
Papillary Thyroid Carcinoma, Lymph Node Cancer Metastatic
Multiomics Study of Biological Behavior of Lymph Node Metastasis in Papillary Thyroid Carcinoma
Establish a predictive model for assessing neck lymph node metastasis of papillary thyroid carcinoma based on metabolomics, proteomics, and imaging omics data, exploring an ideal protocal for the precise diagnosis and treatment…
- Trial name
- NCT06725628
- Testing
- Thy_CLNM_multi_omics
- Volunteers
- 2,000 people
- Sponsor
- Tianhan Zhou
Esophageal Squamous Cell Carcinoma
Radiotherapy Target Volume Delineation in Locally Advanced Esophageal Cancer in the Immunotherapy Era
This prospective observational cohort study will evaluate different radiotherapy target volume delineation patterns in patients with locally advanced esophageal squamous cell carcinoma receiving radiotherapy combined with…
- Trial name
- NCT07858630
- Testing
- GTV-CTV Longitudinal Margin, Regional Lymph Node Irradiation Strategy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Neck Dissection, Radical Lymph Node Dissection
Indocyanine Green Lymphangiography in Identifying Thoracic Duct During Neck Surgery
This phase I trial studies how well indocyanine green lymphangiography works in identifying thoracic duct during neck surgery. Diagnostic procedures, such as near infrared fluorescence imaging with indocyanine green may help…
- Trial name
- NCT03532581
- Testing
- Indocyanine Green Solution, Lymphangiography
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
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