Clinical trials: Lymph Node
Lymphoma, Myeloma
CD70.CAR for CD70+ Lymphoma, Myeloma and Solid Tumors
This study is for patients who have a type of cancer that expresses the protein CD70, which includes lymphoma (lymph gland cancer), myeloma and solid tumors including some sarcomas and kidney cancers, and the cancer has come back…
- Conditions
- Lymphoma, Myeloma, Solid Tumors, Sarcoma
- Trial name
- CALySSEY (NCT07297160)
- Testing
- Dose Level -1, Dose Level 1 (starting dose level), Dose Level 2
- Where
- 2 sites in United States
- Sponsor
- Baylor College of Medicine
Urinary Bladder Neoplasms, Prostatic Neoplasms
Lymphedema After Urologic Surgery
Lymphedema of the extremities is common after lymph node surgery in treating several forms of cancer, e.g., breast cancer. However, very little is known of the occurrence of lymphedema of the lower extremities after urologic…
- Conditions
- Urinary Bladder Neoplasms, Prostatic Neoplasms, Testicular Neoplasms, Penile Cancer
- Trial name
- NCT05264337
- Testing
- Self-reported lymphedema, Dielectric constant ratio, Limb volume
- Where
- 2 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Lung Cancer, Esophageal Cancer
NIR Fluorescence Imaging Technique in Thoracic Surgery With ICG
This study aims to first apply near-infrared fluorescence imaging technology in thoracic surgery with indocyanine green in China.
- Trial name
- NCT02611245
- Testing
- Indocyanine green
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese Academy of Sciences
Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining…
- Conditions
- Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic, Cholangiocarcinoma Resectable, Cholangiocarcinoma; Liver
- Trial name
- LyMIC (NCT06381648)
- Testing
- LyMIC (Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma)
- Where
- 4 sites in United States, Japan
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Immune Response in Cervical Lymph Nodes of Patients With Head and Neck Cancer
Objective: The aim of this study is to characterize the inflammatory response in patients with head and neck cancer. More specifically, the study intend to investigate inflammatory and genetic differences between the primary…
- Trial name
- NCT07131566
- Testing
- Sentinel Node detection and Biopsy
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Lars Olaf Cardell
Breast Cancer, Melanoma
Second Echelon Node Study With Methylene Blue
The investigators plan to study the ability to identify the lymph nodes beyond the sentinel lymph node that may harbor cancer using methylene blue dye.
- Trial name
- NCT01823172
- Testing
- Methylene blue dye injection of sentinel lymph node
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Breast Cancer
Permanence of Indocyanine Green in Axillary Lymph Nodes 3 Weeks After Subdermal Injection in Patients With Breast Cancer and Metastatic Lymph Nodes
In the case of a pre-operative diagnosis of ductal carcinoma in situ (DCIS), sentinel lymph node biopsy is generally not indicated whereas it is considered standard clinical practice for patients with clinical stage I-II…
- Trial name
- FLUO (NCT06347354)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Breast Cancer
Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery
Although there is no doubt that the presence of lymph node metastases worsens prognosis of a patient, unambiguous evidence to support lymph node dissection is still lacking.
- Trial name
- INSEMA (NCT02466737)
- Testing
- no axillary surgery versus SLNB, SLNB versus completion ALND
- Where
- 150 sites in Austria, Germany
- Volunteers
- 5,505 people
- Sponsor
- University of Rostock
Breast Cancer
Thoracoscopic Sentinel Lymph Node Biopsy in Patients With Stage I or Stage II Breast Cancer
RATIONALE: Diagnostic procedures, such as thoracoscopic sentinel lymph node biopsy, may help find breast cancer that has spread to lymph nodes between the breasts. It may also help doctors plan the best treatment.
- Trial name
- NCT00450723
- Testing
- Isosulfan blue, Axillary Lymph Node Dissection, Surgery
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Miami
Breast Cancer
Adjuvant High-Dose, Sequential Chemotherapy in Treating Patients With Resected Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002679
- Testing
- filgrastim, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Yale University
Neck Lymph Node Dissection, Immune Defects
Aerobic Exercises Versus Laser Puncture on Immune Response Following Neck Lymph Node Dissection
Group (1): Twenty cases with decreased white blood cell counts after neck lymph nodes and deficient in blood immunological functions made up this group. They underwent aerobic exercise training on a cycle ergometer.
- Trial name
- NCT06762886
- Testing
- Cycle ergometer, Low-level laser therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Non Small Cell Lung Cancer, Lymph Node Metastasis
PET-CT Predicting Lymph Nodes Metastasis
This study is a single-center prospective clinical study that aims to evaluate the predictive value of preoperative 18F-FDG-PET-CT and 18F-FAPI-PET/CT for lymph node metastasis in patients with non-small cell lung cancer.
- Conditions
- Non Small Cell Lung Cancer, Lymph Node Metastasis, Positron Emission Tomography
- Trial name
- NCT05970913
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Fudan University
Papillary Thyroid Cancer, Lymph Node Metastasis
Frozen Section-Guided Selective Ipsilateral Central Neck Dissection in Bethesda V-VI Thyroid Nodules
The goal of this observational pilot cohort study is to evaluate the feasibility and clinical implications of frozen section analysis-guided selective ipsilateral central neck dissection in adult patients undergoing primary…
- Trial name
- NCT07659717
- Testing
- Frozen section analysis (FSA)
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Eleonora Lori, MD
Lung Cancer
Sentinel Lymph Node Mapping in Detecting Cancer That Has Spread to Lymph Nodes in Patients With Non-Small Cell Lung Cancer
RATIONALE: Diagnostic procedures such as sentinel lymph node mapping may improve the ability to detect cancer that has spread to the lymph nodes.
- Trial name
- NCT00089310
- Testing
- technetium-99
- Where
- 12 sites in United States
- Volunteers
- 46 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Squamous Cell Carcinoma
Two-field Versus Three-field Lymph Node Dissection in ESCC After Neoadjuvant Therapy
Comparison of esophagectomy with Two-field Versus Three-field lymphadenectomy in locally advanced ESCC patients after neoadjuvant therapy
- Trial name
- NCT05420480
- Testing
- Two-Field lymph node dissection, Three-Field lymph node dissection
- Where
- China
- Volunteers
- 323 people
- Sponsor
- Shanghai Zhongshan Hospital
Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc)
Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III)
In the POELH-II trial (Clinicaltrials.gov ID NCT05678218) patients with presumed resectable perihilar (pCCA), intrahepatic (iCCA) or mid-common bile duct (CBD) cholangiocarcinoma had the outcomes of their preoperative endoscopic…
- Conditions
- Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc), Cholangiocarcinoma, Perihilar Cholangiocarcinoma
- Trial name
- POELH-III (NCT07161869)
- Testing
- Registration of all findings during preoperative Endoscopic Ultrasound
- Where
- 6 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Erasmus Medical Center
ESCC, Adjuvant Treatment
Pembrolizumab in Post Radical Operation ESCC Patients With Lymph Node Positive ( KEYSTONE-004 )
The purpose of this study is to observe and evaluate the efficacy and safety of postoperative adjuvant treatment of pembrolizumab in patients with thoracic esophageal squamous cell carcinoma （ESCC） who have not received…
- Conditions
- ESCC, Adjuvant Treatment, Lymph Node Positive, Pembrolizumab
- Trial name
- NCT04863079
- Testing
- Pembrolizumab Injection [Keytruda]
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Prostate Cancer
Bilateral Versus Unilateral Lymph Node Dissection in High-Risk Prostate Cancer (BALANCE)
BALANCE is a multicenter, prospective, randomized controlled trial enrolling men with unilateral high-risk localized prostate cancer identified by prostate biopsy, multiparametric MRI, and PSMA PET imaging.
- Trial name
- BALANCE (NCT07580196)
- Testing
- Unilateral Extended Pelvic Lymph Node Dissection, Bilateral Extended Pelvic Lymph Node Dissection
- Where
- 14 sites in Italy
- Volunteers
- 820 people
- Sponsor
- University of Turin, Italy
Prostate Cancer, Positron Emission Tomography
Radio-guided Surgery With DROP-IN Beta Probe for 68Ga-PSMA, in High-risk Prostate Cancer Patients Eligible for Robotic-assisted Radical Prostatectomy.
The goal of this observational study is to evaluate the diagnostic efficacy and the safety of the combined approach with β-probe and 68Ga-PSMA-11 PET/CT in the correct identification of lymph node metastases, in high-risk…
- Conditions
- Prostate Cancer, Positron Emission Tomography, PSMA
- Trial name
- NCT05596851
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- European Institute of Oncology
Kawasaki Disease
Safety and Vascular Remodelling After BVS Implantation for Stenotic or Occluded Lesions in Children and Young Adults With KD.
To investigate the safety and long-term vascular remodeling after bioresorbable vascular scaffold (BVS) implantation for stenotic or occluded lesion in children or young adults with Kawasaki disease (KD).
- Trial name
- NCT02771288
- Testing
- Bioresorbable Vascular Scaffold
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
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