Clinical trials: Lymph Node
Head and Neck Squamous Cell Carcinoma, Lymph Node Metastasis
Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell Carcinomas
This study evaluates the safety and effectiveness of MPB-2043, a superparamagnetic iron oxide (SPIO) contrast agent, for enhancing MRI in detecting metastatic lymph nodes in head and neck cancer.
- Trial name
- NCT06540443
- Testing
- MPB-2043 of 0.5 mg/kg, MPB-2043 of 1.0 mg/kg, MPB-2043 of 2.0 mg/kg
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- MegaPro Biomedical Co. Ltd.
Sentinel Lymph Node Biopsy
Axillary Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients With Initial cN1 Breast Cancer
SLNB has been recommended by domestic and foreign guidelines for patients with initial cN1 and NAC descending to ycN0. However, the best technical path is still not very clear at present, and the long-term tumor safety data is…
- Trial name
- NCT06518135
- Testing
- SLNB group
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Henan Cancer Hospital
Breast Neoplasm Female, Early-stage Breast Cancer
Deep Learning Algorithms for Prediction of Lymph Node Metastasis and Prognosis in Breast Cancer MRI Radiomics (RBC-01)
This bi-directional, multicentre study aims to assess multiparametric MRI Radiomics-based prediction model for identifying metastasis lymph nodes and prognostic prediction in breast cancer.
- Conditions
- Breast Neoplasm Female, Early-stage Breast Cancer, Radiomics, Axillary Lymph Node
- Trial name
- NCT04003558
- Testing
- No interventions
- Where
- 5 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer
This pilot phase I and randomized phase II trial studies the best way to perform axillary lymph node preservation surgery and to see how well it works in preventing lymphedema in patients with breast cancer.
- Trial name
- NCT00932035
- Testing
- axillary lymph node dissection, isosulfan blue based lymphatic mapping, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- City of Hope Medical Center
Breast Neoplasms
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer
RATIONALE: Patients with HER2-negative advanced breast cancer have limited choice on targeted therapies, and often show only modest responses to available immunotherapies.
- Trial name
- NCT06121557
- Testing
- Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Prostate Cancer
Evaluation of dAroLutamide Addition to anDrogen Deprivation Therapy and radIatioN Therapy in Newly Diagnosed Prostate Cancer With Pelvic Lymph Nodes Metastases
Prospective, multicenter, comparative, randomized placebo-controlled Phase III trial - patients with hormone-naïve prostate cancer and pelvic lymph nodes metastases
- Trial name
- ALADDIN (NCT05116475)
- Testing
- Darolutamide 300 mg
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Mucositis, Stomatitis
Safety of Phenylephrine for Oral Mucositis Prevention
The purpose of this study is to determine if applying the drug phenylephrine to the inside of the mouth can be done safely and is tolerable to use in cancer patients receiving radiation to the Sub-mandibular lymph nodes.
- Trial name
- NCT01092975
- Testing
- phenylephrine solution
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Wisconsin, Madison
Malignant Melanoma
Suction Drain in Axillary Lymph Node Dissection for Malignant Melanoma
Postoperative complications like seroma formation and wound site infection readily occur following completion axillary lymph node dissection (ALND) for malignant melanoma.
- Trial name
- NCT04648163
- Where
- Austria
- Volunteers
- 118 people
- Sponsor
- Medical University of Graz
Gastric Carcinoma
Exploration of Lymph Node Metastasis and Tumor Deposit in the Posterior Gastric Mesentery for Distal Gastric Cancer
This study aims to evaluate lymph node metastasis and tumor deposit in the posterior gastric mesentery following distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer.
- Trial name
- zydgc001 (NCT06736847)
- Testing
- distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jichao Qin
Lung Cancer
Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer
This research study is studying a new imaging method that will show lymph nodes in the lung during lung cancer surgery. The name of the study intervention involved in this study is: -- The combination of the FluoSCOPE device and…
- Trial name
- NCT02423148
- Testing
- Indocyanine green (ICG), FluoSCOPE
- Sponsor
- Dana-Farber Cancer Institute
Adenocarcinoma of the Esophagogastric Junction
Novel Staging Schemes for Siewert Type II Esophagogastric Junction Adenocarcinoma: A Real-World Data Cohort Study From SEER Database
This study have two aims, the first is to explore the optimal cutoff of TLN for Siewert type II AEG using the Surveillance, Epidemiology, and End Results (SEER) database the second is to provide a more accurate staging for…
- Trial name
- NCT05419349
- Testing
- esophagogastric junction cancer surgery
- Where
- China
- Volunteers
- 1,819 people
- Sponsor
- Fujian Medical University Union Hospital
Non Palpable Cervical Lesions Suspicious for Metastasis
Ultrasound-Guided Hook-Wire Localization for Excision of Non-palpable Cervical Lesions Suspicious for Metastasis
The goal of this randomized controlled trial is to determine whether ultrasound-guided hook-wire localization improves surgical efficiency and accuracy compared with ultrasound-guided surgery alone for the excision of…
- Trial name
- NCT07672912
- Testing
- Ultrasound-guided hook-wire localization, Ultrasound-guided surgical excision alone
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Rusana Bark
Breast Cancer
Ultrasound-assisted CNSs Mapping Versus Dual-tracer-guided Sentinel Lymph Node Biopsy
The investigators suggested ultrasound-assisted Carbon nanoparticle suspensions (CNSs) mapping had great clinical value in clinical application and might serve as a useful alternative to the dual-tracer-guided SLNB.
- Trial name
- UltraCars (NCT04951245)
- Testing
- UC group: ultrasound-assisted CNSs guided, GC group: CNSs plus ICG dual-tracer-guided
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Guangdong Provincial People's Hospital
Recurrence, Metastasis
Lymph Node Dissection in High-risk UTUC(Upper Tract Urothelial Carcinoma)
This clinical trial is designed to evaluate the role of lymph node dissection in the prevention of recurrence and metastasis after radical nephroureterectomy for high-risk primary upper tract urothelial carcinoma (UTUC) patients.
- Conditions
- Recurrence, Metastasis, Upper Tract Urothelial Carcinoma, Lymph Node Dissection
- Trial name
- UTUC (NCT03230201)
- Testing
- Lymph node dissection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Lung Cancer
Detection of Genetic Markers of Lung Cancer
The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.
- Trial name
- NCT00280202
- Testing
- Biopsy of the major carinal area, Biopsy of abnormal & suspicious areas of the bronchial tree, Evaluation of the tumor for DNA mutations
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- University of Pittsburgh
Progression, Postoperative Recovery
A Single-center Study on the Effect of Systemic/Selective Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With Components With Consolidation/Tumor Ratio Between 0.5-1
A single-center study on the effect of systemic/selective lymph node dissection on the prognosis of ground glass nodules smaller than 3cm and with components with consolidation/tumor ratio between 0.5-1
- Trial name
- NCT05184829
- Testing
- selective lymph node dissection, Systemic Lymph Node Dissection
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer
Proton Therapy for Lymph Nodes in Breast Cancer
The purpose of this study is to determine if proton radiation therapy will reduce the amount of heart that is exposed to radiation, thereby decreasing the frequency and/or severity of any cardiac side effects.
- Trial name
- BR01 (NCT01365845)
- Testing
- Photon, 3D-Proton/Conventional plan or 3D-proton only
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Gastric Cancer
A Phase II Clinical Trial of Reduced Port Totally Laparoscopic Distal Gastrectomy With D2 Lymph Node Dissection
The purpose of this study is to determine if reduced port totally laparoscopic distal gastrectomy with complete D2 lymph node dissection for gastric cancer is safe and oncological feasible.
- Trial name
- NCT02311595
- Testing
- reduced port laparoscopic distal gastrectomy
- Volunteers
- 67 people
- Sponsor
- Samsung Medical Center
Non-Small Cell Lung Cancer
ArticuGrasp Trial: New Flexible Tool vs Standard Grasper for Lung Cancer Node Removal in Keyhole Chest Surgery
This study is testing whether a new, flexible surgical tool-the SurgeoFlex Grasp-makes keyhole chest operations for early-stage lung cancer easier, faster, and safer than the standard rigid tool used today.
- Trial name
- NCT07201077
- Testing
- Articulating lymph-node grasper (SurgeoFlex Grasp), Arm 2 Intervention Name Traditional rigid endograsper
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jianxing He
Esophageal Cancer
Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced or Recurrent Esophageal Squamous Cell Carcinoma
The goal of this observational study is to to determine whether patients with a high proportion of precursor exhausted T cells (Tpex) in negative tumor draining lymph nodes have longer overall survival.
- Trial name
- NCT07533357
- Volunteers
- 158 people
- Sponsor
- Fudan University
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