Clinical trials: Lymph Node
Kawasaki Disease
Measurement of Antibodies in Adults With a History of Kawasaki Disease
Kawasaki disease (KD) is an acute systemic vasculitic syndrome with coronary tropism. It has been reported worldwide, but it is ten times more common in Asian population.
- Trial name
- KAWASAKI Ac (NCT02853266)
- Testing
- laboratory biomarker analysis
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Colon Cancer
Sentinel Lymph Node Mapping and Analysis in Colon Cancer Using Indocyanine Green Dye
Approximately 20-30 % of colon cancer patients who have no metastasis in lymph nodes after definitive colectomy have recurrence with distant metastasis.
- Trial name
- NCT04351009
- Testing
- sentinel lymph node mapping
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Asian Institute of Gastroenterology, India
Non-Small Cell Lung Cancer NSCLC
Clinical Study of 18F-Alfatide Injection PET/CT
This is a multicenter, open, non-inferiority Phase III clinical study to evaluate the efficacy of 18F-Alfatide Injection PET/CT compared with 18F-FDG PET/CT in the diagnosis of lymph node metastasis in non-small cell lung cancer.
- Trial name
- NCT06416852
- Testing
- 18F-Alfatide Injection, 18F-FDG Injection
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Yantai LNC Biotechnology Singapore PTE. LTD.
Sentinel Lymph Node, Endometrial Cancer
Sentinel Lymph Node in Early-Stage Endometrium Cancer
The aim of this prospective study is to investigate whether the detection rate of sentinel lymph node (SLN) with double tracer injected at two different sites may be increased compared to the standard use of a single tracer with…
- Trial name
- NCT06163963
- Testing
- Sentinel Lymph Node Mapping With Double Tracer and Double Injection Sites in Early-Stage Endometrium Cancer, charcoal injection to uterus to map sentinel lymph nodes
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Malignant Neoplasm of Bladder, Muscle Invasive Bladder Carcinoma
Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy
The goal of this clinical trial is to determine if a partial cystectomy with extended pelvic lymph node removal will be effective at treating Muscle-Invasive Bladder Cancer instead of a complete cystectomy with extended pelvic…
- Trial name
- NCT06290687
- Testing
- Neoadjuvant Chemotherapy, Partial cystectomy with Extended pelvic lymph node dissection, Adjuvant systemic therapy
- Sponsor
- Case Comprehensive Cancer Center
Testicular Cancer
Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular…
- Trial name
- RPLND (NCT06593665)
- Testing
- Inrathecal Morphine, Intravenous Methadone
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Indiana University
Lymph Node Metastasis
Machine Learning to Predict Lymph Node Metastasis in T1 Esophageal Squamous Cell Carcinoma
Existing models do poorly when it comes to quantifying the risk of Lymph node metastases (LNM). This study generated elastic net regression (ELR), random forest (RF), extreme gradient boosting (XGB), and a combined (ensemble)…
- Trial name
- NCT06256185
- Testing
- esophagectomy
- Where
- China
- Volunteers
- 1,267 people
- Sponsor
- Shanghai Zhongshan Hospital
Advanced Right-sided Colon Cancer, the Extent of Lymph Node Dissection
Extent of Lymph Node Dissection for Advanced Right-Sided Colon Cance
This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.
- Trial name
- MARCH (NCT06986538)
- Testing
- Clearance with the left side of the SMV as the medial boundary, Clearance with the left side of the SMA as the medial boundary
- Where
- 26 sites in China
- Volunteers
- 1,064 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Uterine Cervical Neoplasms
Exploratory Study on NIRFI Technology Combined with ICG Guided Cervical Cancer Lymph Node Metastasis
The goal of this exploratory study is to exploring the lymph node metastasis, tumor margin, blood vessels, ureters, and nerve imaging in cervical cancer surgery using near-infrared fluorescence imaging technology combined with…
- Trial name
- NCT06840418
- Testing
- Indocyanine green (ICG) injection for intraoperative lymph node imaging
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Vulvar Cancer
A Non-Randomized Study to Evaluate Leg Lymphatic Drainage Associated With Surgical Intervention for Vulvar Cancer
This will be a non-blinded, non-randomized study to further our knowledge of and experience with lymph node surgery. The investigators are interested in documenting and reporting the variations in leg lymphatic drainage sentinel…
- Trial name
- NCT01321697
- Testing
- Routine Leg edema and groin dissection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arkansas
HIV Infections
Evaluation of the Changes in HIV-1 Burden in Peripheral Blood and Lymphoid Tissue Following Zidovudine ( AZT ) Treatment in HIV-1-Infected Patients With CD4+ Cells Between 100 and 500 Cells/mm3.
PRIMARY: To determine the effect of 8 weeks of zidovudine (AZT) treatment on the HIV-1 burden in peripheral blood and lymphoid tissue in HIV-1-infected, AZT-naive patients with CD4+ T lymphocyte counts between 100 and 500…
- Trial name
- NCT00000818
- Testing
- Zidovudine
- Where
- 9 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
Diffuse Optical Imaging With Indocyanine Green Solution in Imaging Pelvic Lymph Nodes in Patients With Stage II Prostate Cancer Undergoing Surgery
This clinical trial studies diffuse optical imaging with indocyanine green solution in imaging pelvic lymph nodes in patients with stage II prostate cancer undergoing surgery.
- Trial name
- NCT02119858
- Testing
- indocyanine green solution, diffuse optical imaging, robot-assisted laparoscopic surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
Comparison of Diagnostic Performance of an Algorithm and a High Definition Classical Iterative Algorithm Positron Emission Tomography (PET) to 18Fluoro-deoxy-glucose (18FDG) in the Evaluation of Axillary Lymph Node Invasion of Breast Tumors
The primary endpoint of this study is to show that this algorithm in high definition is superior to the classical algorithm in the diagnosis of lymph node metastases.
- Trial name
- TEP-Sein (NCT01436591)
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Francois Baclesse
Cutaneous Squamous Cell Carcinoma (CSCC)
Testing Whether Skin Cancer Has Spread to Nearby Lymph Nodes
This study is about a type of skin cancer called high-risk cutaneous squamous cell carcinoma (HRcSCC). Although most people with this type of skin cancer are successfully treated, some patients have a higher chance that the…
- Trial name
- CECRE (NCT07746258)
- Testing
- Lymphadenectomy
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Germans Trias i Pujol Hospital
Gastric Cancer, Splenic Hilum Lymph Nodes Dissection
Laparoscopic-assisted Total Gastrectomy Versus Open Total Gastrectomy With Splenic Hilum Lymph Nodes Dissection
This study investigates the safety and feasibility of laparoscopic-assisted total gastrectomy with spleen-preserving splenic hilum lymph node dissection for proximal advanced gastric cancer and compares the early results of this…
- Conditions
- Gastric Cancer, Splenic Hilum Lymph Nodes Dissection, Total Gastrectomy
- Trial name
- NCT02711033
- Testing
- Laparoscopic-assisted total gastrectomy, Open total gastrectomy
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Melanoma, Ovarian Cancer
Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy
The purpose of this study is to find out which way of giving high-dose radiation works best for treatment of cancer that has spread to bone, the spine, soft tissue, or lymph nodes.
- Conditions
- Melanoma, Ovarian Cancer, Sarcoma, Bone
- Trial name
- NCT01223248
- Testing
- IGIMRT using a single dose of 24 Gy, IGIMRT 27 Gy in 3 fractions
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 220 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Validation Study Using the GeneSearch BLN Assay to Test Sentinel Lymph Nodes From Patients With Breast Cancer
The purpose of this trial is to show adequate assay performance on clinical samples tested in real time at the clinical site.
- Trial name
- NCT00551278
- Testing
- GeneSearch™ Breast Lymph Node (BLN) Assay
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Janssen Diagnostics, LLC
Breast Cancer
Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla
The patients undergoing axillary lymph node dissection were randomized into 3 groups: patients undergoing lavages with normal saline (Group 1), patients undergoing lavage gentamicin solution (Group 2) and patients undergoing…
- Trial name
- NCT02314806
- Testing
- Irrigation with gentamicin solution, Irrigation with Clindamycin solution, Irrigation with Normal saline
- Volunteers
- 51 people
- Sponsor
- Hospital General Universitario Elche
Cutaneous Squamous Cell Carcinoma of the Head and Neck
Surveillance of Regional Nodal Basins in Patients With Primary High Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck
In this prospective cohort study, investigators will conduct ultrasound surveillance of the nodal basins of patients with head and neck cutaneous squamous cell carcinoma (cSCC) whose tumors are considered high risk and staged by…
- Trial name
- NCT05956795
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Breast Cancer
PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients
The purpose of this study is to provide prospective evidence in the US population of the frequency of skin discoloration and Sentinel Lymph Node detection rate in patients who have recevied Magtrace for Sentinel Lymph Node Biopsy…
- Trial name
- MAGProm (NCT06610539)
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Endomagnetics Ltd.
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