Clinical trials: Lymph Node
Breast Cancer
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I Breast Cancer
RATIONALE: Surgery to remove axillary lymph nodes may be an effective treatment for women with breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of therapy with or without axillary lymph node…
- Trial name
- NCT00002720
- Testing
- tamoxifen citrate, conventional surgery
- Where
- Italy
- Volunteers
- 642 people
- Sponsor
- European Institute of Oncology
Gastric Cancer Stage II, Gastric Cancer Stage III
Investigation of Impact of Indocyanine Green on Volume of Lymphadenectomy in Resectable Gastric Cancer
The study aims to evaluate the safety and benefits of using indocyanine green in lymph node dissection for gastric cancer surgery. The primary endpoint is the average number of lymph nodes removed.
- Conditions
- Gastric Cancer Stage II, Gastric Cancer Stage III, Gastric Cancer, Gastrectomy for Gastric Cancer
- Trial name
- ICGastr (NCT06755554)
- Testing
- Endoscopic injection of Indocyanine green
- Where
- 2 sites in Ukraine
- Volunteers
- 105 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Hypersensitivity, Hay Fever
Immunological Analysis of Lymph Node Tissue After Intralymphatic Immunotherapy: A Prospective Case Control Study
Allergy is a public health problem as more than 20% of western society is affected by it. Symptomatic treatment of allergy suffices with less severe allergy.
- Conditions
- Hypersensitivity, Hay Fever, Rhinitis, Allergic, Seasonal, Rhinoconjunctivitis
- Trial name
- ILIT-FNA (NCT05960266)
- Testing
- Polvac Grass+Rye
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Rectal Cancer
Carbon Nanoparticles as Lymph Node Tracer in Rectal Cancer After Neoadjuvant Radiochemotherapy
The purpose of this study is to evaluate whether injection of carbon nanoparticle as a lymph node tracer before neoadjuvant radiochemotherapy in rectal cancer can increase lymph node yield after surgery compared which do not…
- Trial name
- CALOR-NAT (NCT03550001)
- Testing
- Injection CNP before NAT
- Volunteers
- 252 people
- Sponsor
- YE Yingjiang
Breast Neoplasms
Light-CT in the Diagnosis of Breast Tumor and Lymph Node
Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns.
- Trial name
- NCT03791853
- Testing
- Light-CT
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes
This study is designed to evaluate the feasibility and safety of axillary radiotherapy for early stage breast cancer with limited positive sentinel lymph nodes.
- Trial name
- NCT02612012
- Testing
- axillary radiotherapy
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fudan University
Endometrial Cancer, Sentinel Lymph Node
Accuracy of Sentinel Lymph Node Biopsy in Nodal Staging of High Risk Endometrial Cancer
The standard of care for women with high risk endometrial cancer is the removal of all visible lymph nodes in the pelvis and lower abdomen to identify if disease has spread to these areas.
- Conditions
- Endometrial Cancer, Sentinel Lymph Node, Indocyanine Green
- Trial name
- EndoSLN (NCT01886066)
- Testing
- Indocyanine Green (ICG)
- Where
- 2 sites in Canada
- Volunteers
- 156 people
- Sponsor
- University Health Network, Toronto
Arm Lymphedema, Breast Cancer
Lymphedema Evaluation After Adjuvant Hypofractionated Radiotherapy for 1-2 Macrometastatic Sentinel Lymph Nodes
In this observational prospective studi patients with invasive breast cancer no more than 5 cm and clinically node negative, scheduled for conservative surgery and Sentinel Node Biopsy (SNB), are enrolled in the protocol if they…
- Conditions
- Arm Lymphedema, Breast Cancer, Radiotherapy Side Effect
- Trial name
- AXILL-ART (NCT06321653)
- Testing
- Hypofractionated radiotherapy scheme
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Melanoma
Nuclear and Near-Infrared (NIR) Imaging in Melanoma
Objectives: 1. To determine the feasibility of using microdose amounts of near-infrared (NIR) fluorescent contrast agent to image tumor-draining and contralateral lymphatics in melanoma patients prior to standard-of-care sentinel…
- Trial name
- NCT01295931
- Testing
- Indocyanine Green (IC-Green), Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Colo-rectal Cancer
Study on the Prediction of Regional Lymph Node Metastasis in Colorectal Cancer by Spectral CT Combined With MSI
Spectral CT was used to prospectively collect medical images and clinical data related to colorectal cancer, evaluate the effect of image quality in the diagnosis of colorectal cancer, and evaluate the application value in the…
- Trial name
- NCT07565831
- Testing
- Investigating the role of spectral CT combined with MSI status in the diagnosis and treatment of colorectal cancer lymph nodes.
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Yunnan Cancer Hospital
Lymphedema, Breast Cancer
Preventing Lymphedema in Axillary Lymph Node Dissection
The researchers are trying to answer if axillary reverse mapping (ARM) with lympho-venous bypass (LVB) in patients undergoing an axillary lymph node dissection reduces the rate and severity of post-operative lymphedema of the arm.
- Conditions
- Lymphedema, Breast Cancer, Melanoma
- Trial name
- NCT03428581
- Testing
- ALND with ARM +/- LVB, ALND
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Mayo Clinic
Breast Cancer
VST-1001 (Dilute Fluorescein) for Lymphatic Mapping & Localization of Lymph Nodes in Patients With Breast Cancer
The purpose of this Phase 1 portion of this clinical research study is to find out what dose of dilute fluorescein is needed for a surgeon to best see important lymph nodes that need to be removed during surgery (a standard of…
- Trial name
- NCT02294565
- Testing
- VST-1001, 99mTc-labeled sulfur colloid
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Vestan, Inc.
Mucocutaneous Lymph Node Syndrome
KIDCARE (Kawasaki Disease Comparative Effectiveness Trial)
Kawasaki disease (KD) is a self-limited illness that affects the heart blood vessels (coronary arteries) of infants and children and is now the most common cause of acquired heart disease in children.
- Trial name
- KIDCARE (NCT03065244)
- Testing
- IVIG, Infliximab
- Where
- 29 sites in United States
- Volunteers
- 105 people
- Sponsor
- University of California, San Diego
Thyroid Cancer
Lateral Neck Lymph Node Mapping in Thyroid Cancer
This study includes papillary thyroid cancer patients who have unpalpable lateral neck lymph nodes but suspicious on ultrasound and/or CT. Carbon nanoparticles is used as the tracer for lateral neck lymph node mapping.
- Trial name
- NCT04312087
- Testing
- Lateral neck sentinel lymph node biopsy, Modified lateral neck lymph node dissection, Super selective lateral neck lymph node dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Breast Cancer
SLNB Combined With WLNB for Axillary De-escalation in Breast Cancer Patients With Abnormal Axillary Nodes
This prospective observational diagnostic study aims to evaluate the feasibility of using sentinel lymph node biopsy combined with wire localized lymph node biopsy (SLNB+WLNB) to identify breast cancer patients with 1-2…
- Trial name
- NCT07791771
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Cancer Hospital & Institute
Renal Cell Carcinoma (RCC)
FAZA PET IMAGING IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS
In renal cell carcinoma (RCC) patients, lymph node metastases detection and treatment are the most critical issues in daily clinical decision-making.
- Trial name
- FAZA (NCT03955393)
- Testing
- 18F-FAZA PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer
Surgery to Remove Sentinel Lymph Nodes With or Without Removing Lymph Nodes in the Armpit in Treating Women With Breast Cancer
RATIONALE: Removing the sentinel lymph nodes and examining them under a microscope may help plan more effective surgery for breast cancer.
- Trial name
- NCT00003830
- Testing
- conventional surgery, Sentinel node resection followed by node examination
- Where
- 78 sites in United States, Canada and 1 more
- Volunteers
- 5,611 people
- Sponsor
- NSABP Foundation Inc
Breast Neoplasms, Sentinel Lymph Node
A Prospective Single-center Cohort Study "Preoperative Identification of Sentinel Lymph Nodes Using Contrast-enhanced CT Lymphography in Breast Cancer Patients"
The main hypothesis of this study is that contrast-enhanced CT lymphography can be used for preoperative visualization of sentinel lymph nodes in breast cancer patients.
- Trial name
- NCT04930692
- Testing
- Contrast-enhanced CT lymphography with the periareolar injection of iopamidol
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- Saint Petersburg State University, Russia
Triple Negative Breast Cancer
Study to Identify Molecular Mechanisms of Clinical Resistance to Chemotherapy in Triple Negative Breast Cancer Patients
This is a multicenter translational study to understand therapeutic resistance in patients undergoing standard chemotherapy for triple negative breast cancer.
- Trial name
- NCT01276899
- Testing
- Needle core biopsies, Needle core biopsies of metastatic lesion
- Where
- 8 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- Jewish General Hospital
Breast Neoplasms
The Significance of Radiologically Detected Intramammary Lymph Nodes in Prediction of Axillary Lymph Nodes Status in Breast Cancer Patients
Breast cancer is a major cause of mortality among women if not treated in early stages. Early screening and diagnosis have a lot to do with the therapeutic effect of prognosis .
- Trial name
- NCT05214781
- Testing
- modified radical mastectomy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
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