Clinical trials: Lymph Node Disease
Cervical Cancer, Surgery
Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-stage Cervical Cancer (PHENIX/CSEM 010)
The diagnostic value of sentinel lymph node biopsy in early-stage cervical cancer has been well studied. However, there were no randomized controlled study on comparing the long-term outcomes of sentinel lymph node biopsy and…
- Conditions
- Cervical Cancer, Surgery, Quality of Life
- Trial name
- NCT02642471
- Testing
- no systematic pelvic lymphadenectomy
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Sun Yat-sen University
Vulvar Neoplasms, Skin Neoplasms
Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage
The purpose of this study is to evaluate the decrease of post-operative morbidity in inguinal lymphadenectomies realised for vulvar tumors and inferior limb skin tumors by use of Ultracision with regard to classical operative…
- Trial name
- NCT00224744
- Testing
- ultracision, classical lymphadenectomy
- Where
- 2 sites in France
- Volunteers
- 73 people
- Sponsor
- Institut Claudius Regaud
Esophageal Cancer, Indocyanine Green
The Value of Lymph Node Dissection of Indocyanine Green-guided Near-infrared Fluorescent Imaging in Esophagectomy
Indocyanine green (ICG) has been recently introduced in clinical practice as a fuorescent tracer. Lymphadenectomy is particularly challenging in esophageal cancer surgery, owing to the complex anatomical drainage.Therefore, the…
- Trial name
- NCT04615806
- Testing
- Indocyanine green solution
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Ovarian Cancer, Lymph Node Metastasis
Magtrial: Magtrace® as Tracer for Sentinel Lymph Node Detection in Early Stage Epithelial Ovarian Cancer
Epithelial ovarian cancer (EOC) remains the tumour with the most unfavourable prognosis within the field of gynaecological oncology.
- Trial name
- NCT05375526
- Testing
- Magtrace
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Lung Cancer
Utility of Endobronchial Ultrasound Guided Needle Biopsy in Early Stage Non- Small Cell Lung Cancer (NSCLC)
The goal of this clinical research study is to learn how accurately an endobronchial ultrasound transbronchial needle aspiration (EBUS -TBNA) may detect mediastinal lymph node metastases in patients with clinical stage I and II…
- Trial name
- NCT00832715
- Testing
- EBUS-TBNA
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Neoplasm, Neoadjuvant Therapy
RISAS Procedure in Node Positive Breast Cancer Following NAC
Chemotherapy in clinically node positive breast cancer patients is increasingly administrated in a neoadjuvant setting. The standard treatment regimen in these cases is then: neoadjuvant chemotherapy (NAC) followed by breast…
- Conditions
- Breast Neoplasm, Neoadjuvant Therapy, Axillary Lymph Nodes, Pathological Complete Response
- Trial name
- RISAS (NCT02800317)
- Testing
- RISAS
- Where
- 14 sites in Netherlands
- Volunteers
- 248 people
- Sponsor
- Erasmus Medical Center
Cervical Cancer
Sentinel Lymph Node Biopsy in Patients With Early Stages Cervical Cancer
To evaluate whether a less radical surgical approach with sentinel lymph node biopsy is non-inferior to treatment with systematic pelvic lymphadenectomy.
- Trial name
- SENTIX (NCT02494063)
- Testing
- Sentinel lymph node biopsy, At least unilateral systematic pelvic lymph node dissection
- Where
- Czechia
- Volunteers
- 600 people
- Sponsor
- Charles University, Czech Republic
Thyroid Cancer
Lateral Neck Lymph Node Mapping in Thyroid Cancer
This study includes papillary thyroid cancer patients who have unpalpable lateral neck lymph nodes but suspicious on ultrasound and/or CT. Carbon nanoparticles is used as the tracer for lateral neck lymph node mapping.
- Trial name
- NCT04312087
- Testing
- Lateral neck sentinel lymph node biopsy, Modified lateral neck lymph node dissection, Super selective lateral neck lymph node dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Diabetes Mellitus, Type 1, Diabetes Mellitus
Diamyd Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes
The objective of DIAGNODE-2 is to evaluate the efficacy of Diamyd compared to Placebo, upon administration directly into a lymph node in combination with an oral vitamin D/Placebo regimen, in terms of preserving endogenous…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Autoimmune Diseases, Metabolic Disease
- Trial name
- NCT03345004
- Testing
- Diamyd, Vitamin D
- Where
- 18 sites in Czechia, Netherlands and 2 more
- Volunteers
- 109 people
- Sponsor
- Diamyd Medical AB
Breast Cancer
Positive Node Traced Before Neoadjuvant Chemotherapy (NAC)
To investigate this regression model by injecting and tracing carbon nanoparticles (CNs) into the fusion node prior to NAC in patients with breast cancer.
- Trial name
- NCT03355261
- Testing
- complete remission (CR) group, partial remission (PR) group, stable disease (SD) group
- Where
- 3 sites in China
- Volunteers
- 110 people
- Sponsor
- Shengjing Hospital
Thyroid Cancer
The Evaluation of the Diagnostic Properties of Intra-operative In-situ Thyroglobin Levels of Cervical Lymph Nodes, in the Discrimination Between Benign and Malignant Lymph Nodes in Thyroid Cancer: a Prospective Multicentre Study.
Cytological examination of punctured lymph nodes is the gold standard for confirming metastatic lymph node spread of differentiated thyroid cancers.
- Trial name
- Tgcyto (NCT02602717)
- Testing
- lymph nodes cyto-punction
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Kawasaki Disease
A Blood Test to Diagnose Kawasaki Disease
A case-control cohort study is being conducted to develop and validate the performance of a whole blood gene expression qPCR test to distinguish KD from other febrile conditions by collecting whole blood sample from KD patients…
- Trial name
- NCT05091229
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Melanoma Stage III or IV
Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT00243594
- Testing
- Peptide-pulsed dendritic cells
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes
This study is designed to evaluate the feasibility and safety of axillary radiotherapy for early stage breast cancer with limited positive sentinel lymph nodes.
- Trial name
- NCT02612012
- Testing
- axillary radiotherapy
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fudan University
Non-small Cell Lung Cancer
The Accuracy of Targeted Lymph Node Dissection of Non-small Cell Lung Cancer Patients According to Predictive Models
Investigators combined the clinical and radiomics characteristics of resectable non-small cell lung cancer patients to construct an accurate model for preoperative prediction of mediastinal lymph node status.
- Trial name
- NCT06768853
- Testing
- Lymph node dissection based on the guidelines, Lymph node dissection based on the model
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongnan Hospital
Breast Cancer
Axillary Reverse Mapping for Invasive Carcinoma of the Breast
Primary Objectives: To determine the feasibility of axillary reverse mapping (ARM) in patients undergoing axillary lymph node dissection for breast cancer therapy.
- Trial name
- NCT00645541
- Testing
- Axillary Reverse Mapping
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Use of Sentinel Lymph Node Biopsy in Patients With Early-Stage, Palpable Node-Positive HR+/HER2- Breast Cancer Having Upfront Surgery and Adjuvant Radiation
The purpose of this study is to find out how often the researchers can avoid an ALND in patients with early-stage, node-positive HR+/HER2- breast cancer who are having upfront surgery.
- Trial name
- NCT04854005
- Testing
- Breast surgery
- Where
- 10 sites in United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Endometrial Cancer
Biomarkers in Tissue Samples From Patients With Stage I or Stage III Endometrial Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01119573
- Testing
- RNA analysis, microarray analysis, reverse transcriptase-polymerase chain reaction
- Volunteers
- 100 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Cancer, Sentinel Lymph Node
Intraoperative Examination of Sentinel Node in Endometrial Cancer (TRSGO-SLN-003)
More than half of the cases with macrometastatic sentinel lymph node (SLN) have non-SLN metastasis and leaving these nodes in-situ may impair the survival.
- Trial name
- TRSGOSLN003 (NCT04560491)
- Testing
- Intraoperative examination of sentinel node
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara University
Breast Cancer, Sentinel Lymph Node
Indocyanine Green Fluorescence-guided Sentinel Node Biopsy in Breast Cancer Within a North African Population: a Retrospective Study
Background Radio Isotopes and Blue dye alone or in combination are the most commonly used tracer agents in sentinel Node Biopsy for early breast cancer.
- Trial name
- NCT04879680
- Testing
- sentinel node detection
- Volunteers
- 47 people
- Sponsor
- Faculty of Medicine, Sousse