Clinical trials: Lymph Node Neoplasm
Thyroid Cancer, Thyroidectomy With Central Lymph Node Dissection
Does Parathyroid Autofluorescence Reduces Unintensional Parathyroidectomy During Total Thyroidectomy With Central Lymph Node Compartment Dissection
The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.
- Trial name
- FLUOBCC (NCT04339478)
- Where
- 2 sites in Greece, Jordan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Breast Cancer, Lymph Node Metastasis
Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer
The purpose of this study is to determine how circulating tumor DNA (ctDNA), a sign of minimal residual disease (MRD), is detectable after surgery in patients with early HR+/HER2- breast cancer that has spread to 1-3 lymph nodes.
- Trial name
- NCT07025785
- Testing
- Circulating tumor DNA
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer, Breast Surgery
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia.
- Conditions
- Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue
- Trial name
- NCT07040540
- Testing
- Methylene Blue, Standard Surgical Care Without Dye
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Lung Cancer, Lymph Node Metastasis
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist.
- Conditions
- Lung Cancer, Lymph Node Metastasis, Pathologic Processes
- Trial name
- NCT06252129
- Testing
- Subjects undergoing a lung specimen lymph node dissection, Control group
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Head and Neck Cancer (H&Amp;Amp;N), Lymph Nodes
The eValuation of Sources of vIBRAtioN for Vibrational Shear Wave elasTography
Patients suffering with Head and Neck Cancer often must wait 3 months or more to know if their treatment has been effective, which can be very stressful.
- Trial name
- VIBRANT (NCT07098819)
- Testing
- Vibrational Shear wave elastography algorithm
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Sentinel Lymph Node Biopsy, Neoadjuvant Therapy
Clinical Application of Multi-modal Sentinel Lymph Node Staining Method in Breast Cancer Patients After Neoadjuvant Chemotherapy
This clinical trial aimed to confirm the effectiveness of sentinel lymph node surgery by determining the lymph node identification rate using multimodal sentinel lymph node marker methods in patients with advanced breast cancer…
- Conditions
- Sentinel Lymph Node Biopsy, Neoadjuvant Therapy, Breast Neoplasm
- Trial name
- NCT06212440
- Testing
- Radioactive Isotope (RI) Mapping, Indocyanine Green Fluorescence (ICG-F) Mapping, Vital Dye Mapping
- Where
- 2 sites in South Korea
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Lymph Nodes With Tumor Metastasis
Predicting Tumor Origin Based on Deep Learning of Lymph Node Puncture Cytology
In this study, the investigators aimed to construct a deep learning diagnostic model that uses cytological images to predict primary unknown tumor origins in patients with tumors combined with lymph node metastases.
- Trial name
- NCT06810349
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Breast Cancer, Locally Recurrent Breast Cancer
Photo-medicine-Guided Dual Approach for Reoperation of Sentinel Lymph Nodes in Locally Recurrent Breast Cancer Patients
Sentinel lymph node biopsy (SLNB) is essential for staging and treatment planning in early breast cancer patients. As a less invasive procedure, it has replaced axillary lymph node dissection (ALND) by reducing complications and…
- Conditions
- Breast Cancer, Locally Recurrent Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Reoperation
- Trial name
- NCT06780748
- Testing
- Identification rate of sentinel lymph node
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
The Malignant Lesions and Non-malignant Lesions of Pancreas, Bile Duct, Liver and Lymph Node
An Artificial Intelligence System for ROSE of EUS-FNA Sample: a Prospective, Multicenter, Diagnostic Study.
This is an observational study with a prospective, multicenter, disgnostic design. An artificial intelligence system named ROSE-AI system was developed using cytopathological slide images taken by microscope camera or smartphone…
- Trial name
- ROSE，EUS-FNA (NCT06718725)
- Testing
- ROSE-AI system
- Where
- China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Soft Tissue Sarcoma, Lymph Node Cancer
Identification of Surgical Management of Lymph Node Basins and Surgical Practice Patterns Among Sarcoma Surgeons
This study investigates the surgical management of lymph node basins for extremity and trunk soft tissue sarcoma (ETSTS) to identify and better understand the surgical practice patterns of sarcoma surgeons.
- Trial name
- NCT04553744
- Testing
- Survey Administration
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Lymph Node Cancer Metastatic
Axillary Reverse Mapping in Breast Cancer
The axillary mapping reverse (ARM) consists in differentiating the upper limb lymph nodes from the breast ones in order to preserve them and reduce the possibility of lymphedema.
- Trial name
- ARM (NCT05040685)
- Testing
- Axillary mapping reverse
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Gastric Cancer, Lymph Node Metastases
IGG Using in Laparoscopic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy
Patients with locally advanced gastric adenocarcinoma (cT2-4a N-/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph…
- Trial name
- NCT04611997
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Ovarian Cancer, Sentinel Lymph Node
Mapping Sentinel Lymph Node in Initial Stages of Ovarian Cancer
Epithelial ovarian cancer (EOC) diagnosed in the initial stage (stage I-II) require complete staging surgery to histologically assess the possible existence of peritoneal or lymph node disease.
- Trial name
- MELISA (NCT05184140)
- Testing
- Sentinel node detection
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Gastric Cancer, Lymph Node Metastasis
Staging LaParoscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer
Staging LaParscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer (POLA) study aims to investigate the safety and feasibility of ICG-guided SN retrieval in GC patients undergoing multimodal treatment.
- Trial name
- POLA (NCT05720598)
- Testing
- Sentinel Node Assessment, Staging laparoscopy, Gastroscopy with indocyanine green (ICG) injection
- Where
- Poland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Endometrial Cancer, Lymph Node Metastasis
Staging Endometrial caNcer Based on molEcular ClAssification
The SENECA study tries to evaluate the rate of lymph node involvement depending on the molecular subgroup in early-stage endometrial cancer (I/II) patients undergoing surgery as part of their treatment.
- Conditions
- Endometrial Cancer, Lymph Node Metastasis, Sentinel Lymph Node
- Trial name
- NCT05707312
- Where
- Spain
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Sentinel Lymph Node Biopsy
Oncologic Safety of Sentinel Lymph Node Biopsy in Clinically Palpable Axillary Lymph Node in Breast Cancer Patients
Evaluation patients with palpable lymph node with breast cancer by sentinel lymph node biopsy and how to affect on the management of breast cancer.
- Trial name
- NCT05703295
- Testing
- Biopsy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Esophageal Squamous Cell Carcinoma, Benign Lymph Node Neoplasm
Quantitative Analysis of 18F-FAPI Dynamic PET/CT for Accurate Differential Diagnosis of MLN of ESCC
Patients diagnosed with esophageal squamous cell carcinoma based on clinicopathology, laboratory examination and imaging criteria were selected as the research subjects, and compared with conventional 18F-FDG PET/CT.
- Conditions
- Esophageal Squamous Cell Carcinoma, Benign Lymph Node Neoplasm, Malignant Lymph Node Neoplasm
- Trial name
- NCT05287880
- Testing
- Dynamic PET/CT
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Lymph Node Cancer Metastatic
High Dose SBRT for Abdominal-Pelvic Lymph Nodal Lesions in Oligometastatic Patients
This is a prospective, multicentric, phase II and feasibility study aimed to address early and late side effects of hypofractionated ablative radiotherapy for oligometastatic patients with lymph node metastases for…
- Trial name
- NCT02570399
- Testing
- Oligometastatic patients with abdominal-pelvic lymph nodes
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Prostate Cancer, Lymph Node Metastases
Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer.
Standard treatment of local or locally advanced prostate cancer is radical prostatectomy (RRP) surgery. During RRP in certain patients extended lymph node dissection (ELND) is recommended.
- Trial name
- NCT04882618
- Testing
- Indocyanine green
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University