Clinical trials: Lymph Node Neoplasm
Breast Cancer
Premarking of Axillary Nodes Before Start of Neoadjuvant Chemotherapy Using Magnetic Approach
Breast cancer is one of the commonest types of cancers in females. Treatments include surgery followed by anti-estrogen therapy, radiotherapy and chemotherapy.
- Trial name
- SENTINEO (NCT05625698)
- Testing
- MagTrace only, MagTrace and Magseed
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Cervical Cancer
Sentinel Lymph Node Detection in Early Cervical Cancer
The primary objective of this study is to determine the feasibility of detecting the sentinel lymph node (SLN) in patients with early invasive cervical cancer using a combined radioisotope and blue dye technique.
- Trial name
- NCT02543775
- Testing
- Preoperative and intraoperative SLN Mapping
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Surgery to Remove Sentinel Lymph Nodes With or Without Removing Lymph Nodes in the Armpit in Treating Women With Breast Cancer
RATIONALE: Removing the sentinel lymph nodes and examining them under a microscope may help plan more effective surgery for breast cancer.
- Trial name
- NCT00003830
- Testing
- conventional surgery, Sentinel node resection followed by node examination
- Where
- 78 sites in United States, Canada and 1 more
- Volunteers
- 5,611 people
- Sponsor
- NSABP Foundation Inc
Breast Cancer, Radiation Toxicity
Hypofractionated Versus Conventional Fractionation Radiotherapy
This study was designed to evaluate the acute toxicity and quality of life of hypofractionated radiation versus conventional when regional node irradiation is indicated after breast-conserving surgery or mastectomy.
- Trial name
- NCT04015531
- Testing
- Conventional radiotherapy, Hypofractionated radiotherapy
- Volunteers
- 80 people
- Sponsor
- Hospital da Baleia
Malignant Neoplasm
Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes
This early phase I trial studies how well ultrasound-guided photoacoustic imaging works in telling the difference between healthy and cancerous inguinal (groin) lymph nodes and how well it can detect certain features of lymph…
- Trial name
- NCT04185337
- Testing
- Fine-Needle Aspiration, Lymph Node Biopsy, Photoacoustic Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer (H&Amp;Amp;N), Lymph Nodes
The eValuation of Sources of vIBRAtioN for Vibrational Shear Wave elasTography
Patients suffering with Head and Neck Cancer often must wait 3 months or more to know if their treatment has been effective, which can be very stressful.
- Trial name
- VIBRANT (NCT07098819)
- Testing
- Vibrational Shear wave elastography algorithm
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Lung Cancer
Significance of Ultrasound Elastography in Lymph Node
Background and Objectives: Elastography can reflect the difference of tissue hardness, which helps to identify the difference of hardness between benign and malignant tissues.
- Trial name
- NCT03391557
- Testing
- UE
- Volunteers
- 42 people
- Sponsor
- Fangsurong
Prostate Cancer, Positron Emission Tomography
Radio-guided Surgery With DROP-IN Beta Probe for 68Ga-PSMA, in High-risk Prostate Cancer Patients Eligible for Robotic-assisted Radical Prostatectomy.
The goal of this observational study is to evaluate the diagnostic efficacy and the safety of the combined approach with β-probe and 68Ga-PSMA-11 PET/CT in the correct identification of lymph node metastases, in high-risk…
- Conditions
- Prostate Cancer, Positron Emission Tomography, PSMA
- Trial name
- NCT05596851
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- European Institute of Oncology
Melanoma, Head and Neck Cancer
Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes
The aim of this study is to investigate whether the Sentinella camera improves intraoperative detection and removal of sentinel lymph nodes (SLNs) when used in conjunction with standard detection methods.
- Conditions
- Melanoma, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02416336
- Testing
- Sentinella Intraoperative imaging protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oncovision Inc
Adenocarcinoma of the Prostate
Single Photon Emission Computed Tomography (SPECT) Lymph Node Mapping
The purpose of this study is to determine if the planning of radiation treatment of prostate cancer patient can be made more precise by comparing currently planning techniques to an imaging technique called SPECT.
- Trial name
- SPECT (NCT00608920)
- Testing
- Single Photon Emission Computed Tomography (SPECT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Pancreatic Neoplasms
Adjuvant Gemcitabine Versus Gemcitabine With Chemoradiation in Pancreatic Adenocarcinoma With R1 Resection and/or Positive Lymph Nodes
Adjuvant Gemcitabine Versus Gemcitabine With Chemoradiation in Pancreatic Adenocarcinoma With R1 Resection and/or Positive Lymph Nodes after curative resection.
- Trial name
- NCT02754180
- Testing
- Gemcitabine, TS-1 with radiation
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Rectal Cancer, Lymph Node Metastasis
Radioisotope and Fluorescence Guidance in Rectal Cancer
A study to investigate if pelvic side wall lymph nodes that remain after neo-adjuvant chemoradiotherapy can be identified intraoperatively using dual radioisotope and fluorescence guidance.
- Trial name
- NCT05336643
- Testing
- Radiofluorescence
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Prostate Cancer
DAPROCA Pelvic Lymph Node Irradiation to Prostate for High Risk Prostate Cancer: Phase I/II Study
This is a prospective, open label 1 arm study, multicentre, Phase I/II clinical safety study. The trial is designed to gain initial safety and efficacy data on pelvic lymph node radiation with simultaneous integrated boost to…
- Trial name
- Propel (NCT01417676)
- Testing
- Radiation: pelvic lymph nodes with boost to prostate
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- University of Aarhus
Lymph Node Cancer, Cutaneous
Epidemiology and Management of Cutaneous T-Cell Lymphoma at Hospital México, Costa Rica.
Adult patients (≥18 years) with confirmed cutaneous T-cell lymphoma evaluated at Hospital México between 2019 and 2025 will be retrospectively analyzed using EDUS records to describe their epidemiological profile, clinical…
- Conditions
- Lymph Node Cancer, Cutaneous, T-cell Lymphoma
- Trial name
- NCT07538960
- Where
- Costa Rica
- Volunteers
- 350 people
- Sponsor
- Caja Costarricense de Seguro Social
Melanoma
NIR-Guided Sentinel Lymph Node Mapping in Melanoma
This study will try to define an appropriate dose of the investigational drug indocyanine green (ICG) in combination with near infrared (NIR) imaging to use for future studies.
- Trial name
- NCT01121718
- Testing
- ICG Intervention
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Melanoma
Trial of Lymphoseek in Intraoperative Localization of Lymph Nodes in Breast Cancer and Melanoma
Data from this pivotal clinical trial will be used to support a marketing application (i.e., NDA) for Navidea's Lymphoseek for use in intraoperative localization of lymph tissue (nodes) in the lymphatic pathway draining the…
- Trial name
- NCT00671918
- Testing
- Lymphoseek
- Where
- 15 sites in United States, Israel
- Volunteers
- 186 people
- Sponsor
- Navidea Biopharmaceuticals
Breast Cancer
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I Breast Cancer
RATIONALE: Surgery to remove axillary lymph nodes may be an effective treatment for women with breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of therapy with or without axillary lymph node…
- Trial name
- NCT00002720
- Testing
- tamoxifen citrate, conventional surgery
- Where
- Italy
- Volunteers
- 642 people
- Sponsor
- European Institute of Oncology
Prostate Cancer
Study to Assess [177Lu]Lu-PSMA-R2 (AAA602) and [225Ac]Ac-PSMA-R2 (AAA802) in Participants With PSMA-positive HRLPC
The purpose of this trial is to learn more about the effects of AAA602 and AAA802 in men with prostate-specific membrane antigen (PSMA) positive high-risk localized prostate cancer (HRLPC) before surgery to remove the prostate…
- Trial name
- NeoPSMA (NCT06881823)
- Testing
- AAA602, AAA802, Gallium (68Ga) gozetotide
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Axillary Lymph Node Dissection
Upper Extremity Lymphatic Mapping for Breast Cancer Patients
This study is being done to see if lymph nodes that drain the arm also drain the breast. An axillary lymph node dissection removes lymph nodes under the arm.
- Trial name
- NCT00717886
- Testing
- isosulfan blue dye
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Cancer
SLND Versus Non-Dissection Following ESD for T1a Stage Esophageal Squamous Cell Carcinoma
This is a study from Fujian Cancer Hospital Thoracic of Surgery Project, numbered as FJCHTOSP-1. Systematically mediastinal Lymph Node Dissection (SLD) Versus Non-Dissection Following Endoscopic Submucosal Dissection (ESD) for…
- Trial name
- NCT06979986
- Testing
- Endoscopic Submucosal Dissection with Systematically mediastinal Lymph Node Dissection, Endoscopic Submucosal Dissection without SLND
- Volunteers
- 102 people
- Sponsor
- Fujian Cancer Hospital
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