Clinical trials: Lymph Node Neoplasm, open to volunteers
Sentinel Lymph Node Biopsy (SLNB), Melanoma (Skin Cancer)
Evaluating a Decision Aid for Sentinel Lymph Node Biopsy in Intermediate-Risk Melanoma
This research study is testing a decision aid to help patients think through whether to have sentinel lymph node biopsy for melanoma.
- Trial name
- Mel73 (NCT07653087)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Virginia
Carcinoma, Non-Small-Cell Lung
SLND or Not in cT1 GGO Invasive Lung Adenocarcinoma (ECTOP-1009)
This is a study from Eastern Cooperative Thoracic Oncology Project, numbered as ECTOP-1009. Systematically mediastinal lymph node dissection or not in clinical stage T1 ground-glass dominated invasive lung adenocarcinoma: a…
- Trial name
- NCT04527419
- Testing
- No mediastinal lymph node dissection
- Where
- China
- Volunteers
- 545 people
- Sponsor
- Fudan University
Blood Loss, Intensive Care
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission…
- Conditions
- Blood Loss, Intensive Care, Anastomotic Leakage, Lymph Node Disease
- Trial name
- NCT06049758
- Testing
- LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention), Enoxaparin 40 Mg/0.4 mL Injectable Solution, Levofloxacin 500mg
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Progression, Postoperative Recovery
A Single-center Study on the Effect of Systemic/Selective Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With Components With Consolidation/Tumor Ratio Between 0.5-1
A single-center study on the effect of systemic/selective lymph node dissection on the prognosis of ground glass nodules smaller than 3cm and with components with consolidation/tumor ratio between 0.5-1
- Trial name
- NCT05184829
- Testing
- selective lymph node dissection, Systemic Lymph Node Dissection
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer by AJCC V8 Anatomic Stage, Breast Cancer
De-escalation of Axillary Dissection for Node-positive Breast Cancer
Recent studies have demonstrated the safety of de-escalation of nodal surgery for clinically node-positive breast cancer patients after a favorable response to neoadjuvant systemic therapy (NST).
- Trial name
- NCT07856160
- Testing
- TAD, ALND
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Breast Carcinoma Metastatic in Lymph Node, HER2 Positive Breast Carcinoma
Validation of TAD in HER-2 with More Than 2 Lymph Nodes
The main objective of the study is to validate the DAT technique in patients with Her2-positive breast cancer who have more than two positive axillary lymph nodes at diagnosis.
- Trial name
- DAD-HER2 (NCT06821490)
- Testing
- Targeted axillary dissection and subsequently a lymphadenectomy
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Rectal Neoplasm Malignant
Latitude - Lateral Lymph Node Attitude Study
Patients with advanced rectal cancer can sometimes have suspected tumour affected lymph nodes outside the standard operating field. These patients often receive preoperative treatment before surgery.
- Trial name
- Latitude (NCT06896578)
- Testing
- Lateral lymph node dissection
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Sahlgrenska University Hospital
Thyroid Cancer
Selective Neck Dissection Versus Modified Neck Dissection in PTC
This study is a phase III, randomized controlled, open label non inferiority study. Patients who meet the inclusion criteria are randomly assigned 1:1 to either the experimental group (selective neck dissection) or the control…
- Trial name
- NCT06554652
- Testing
- Lymph node tracer navigated selective neck dissection, Modified neck dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Esophageal Squamous Cell Carcinoma (ESCC)
Risk of Esophageal Cancer Returning After Immunotherapy, Chemotherapy, and Surgery
This observational study aims to understand the risk of cancer returning after surgery in people with esophageal squamous cell carcinoma, a type of cancer of the food pipe.
- Trial name
- NCT07822906
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Cancer Hospital & Institute
Cutaneous Squamous Cell Carcinoma (CSCC)
Testing Whether Skin Cancer Has Spread to Nearby Lymph Nodes
This study is about a type of skin cancer called high-risk cutaneous squamous cell carcinoma (HRcSCC). Although most people with this type of skin cancer are successfully treated, some patients have a higher chance that the…
- Trial name
- CECRE (NCT07746258)
- Testing
- Lymphadenectomy
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Germans Trias i Pujol Hospital
Carcinoma, Squamous Cell
A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.
The purpose of this study is to determine whether cervical lymph node dissection is necessarily performed in the presence of early-stage oral squamous cell carcinoma.
- Trial name
- NCT02743832
- Testing
- Resection for primary lesion and cervical lymph node dissection, Resection for primary lesion only
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Jinsong Hou
Testicular Cancer
Study on the Quality of Life and Functional/Oncological Outcome of Testicular Cancer Patients
The research aims to collect data in order to report the main problems related to the testicular cancer; To reach this aim, this study proposes to create a database of the testicular cancer condition.
- Trial name
- NCT06389409
- Testing
- Observation of testicular cancer patients
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- IRCCS San Raffaele
Lymph Node Neoplasm, Lymph Node Metastasis
LN-RADS, RECIST 1.1 and Node-RADS Classification in the Assessment of Lymph Nodes
The project aims to evaluate the value of the new LN-RADS scales for lymph node classification in CT and MR and to compare this method with two other methods RECIST 1.1 and Node-RADS.
- Trial name
- NCT06527027
- Testing
- Lymph node assessment according to RECIST 1.1 in CT, Lymph node assessment according to Node-RADS in CT, Lymph node assessment according to LN-RADS in CT
- Where
- 6 sites in Poland
- Volunteers
- 1,000 people
- Sponsor
- Copernicus Memorial Hospital
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
DCIS, Breast Cancer
Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ
The trial aims to investigate the use of superparamagnetic iron oxide (SPIO) nanoparticles as a tracer for delayed sentinel lymph node dissection (d-SLND) in patients where upfront axillary surgery (SLND) is oncologically deemed…
- Conditions
- DCIS, Breast Cancer, Breast Neoplasms, Sentinel Lymph Node
- Trial name
- SENTINOT_2 (NCT04722692)
- Testing
- Delayed SLND, Late SLND
- Where
- 9 sites in United States, Hong Kong and 1 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University
Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection
Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy
The goal of this randomized controlled clinical trial is to determine whether adding a serratus anterior plane block (SAPB) to a pectoralis II (PECS II) block improves pain relief and reduces the need for opioids in adult women…
- Conditions
- Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection, Nerve Block; Pain Medication, Pectoralis Nerve Block
- Trial name
- PECS (NCT07881237)
- Testing
- Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS)
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- Lebanese American University
Oral Squamous Cell Carcinoma (OSCC)
Evaluation of the Efficacy and Safety of Nivolumab Neoadjuvant Treatment of Patients With Locally Advanced Oral Squamous Cell Carcinoma
This is a Phase II, single-centre, non-randomized, single-arm clinical trial to investigate the efficacy and safety of neoadjuvant nivolumab therapy in adult participants with resectable, locoregionally advanced Oral Squamous…
- Trial name
- NOCANO (NCT07514767)
- Testing
- Nivolumab (240 mg)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Prof. Lars Olaf Cardell
Endometrial Cancer, Cervical Cancer
The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Endometrial and Cervical Cancer. A Multicenter Study.
The role of small-volume lymph node disease (ITC and micro metastases) among patients with endometrial or cervical cancer submitted to sentinel node (SLN) procedure is not clearly defined.
- Conditions
- Endometrial Cancer, Cervical Cancer, Sentinel Lymph Node, Micrometastasis
- Trial name
- ITCMicroUtCa (NCT04403867)
- Testing
- Sentinel lymph node (SLN) biosy +/- lymphadenectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cancer T1-N0 or T2-N0 of the Oral Cavity
Sentinel. Ambulatory. Oral Cavity. Oropharynx (S.A.C.O)
This is a single-center pilot study of open-label, non-randomized interventional research based on the outpatient management of 30 patients with T1-N0 or T2-N0 cancer in the oral cavity or oropharynx.
- Trial name
- SACO (NCT03545256)
- Testing
- outpatient surgery for T1-N0 or T2-N0 cancers of the oral cavity or oropharynx with lymph node search
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Breast Cancer, Breast Neoplasms
Augmented-Reality ICG Fluorescence Second-Look for Residual Nodal Disease After Axillary Dissection in Breast Cancer
This prospective study will enroll up to 200 patients whose clinical team has already planned an axillary lymph node dissection for breast cancer.
- Conditions
- Breast Cancer, Breast Neoplasms, Sentinel Lymph Node, Lymphatic Metastasis
- Trial name
- AR4SLN (NCT07696754)
- Testing
- Augmented-reality ICG fluorescence second-look imaging
- Where
- North Macedonia
- Volunteers
- 200 people
- Sponsor
- Ss. Cyril and Methodius University of Skopje