Clinical trials: Lymph Node Neoplasm
Cancer
Fluorescein for Lymphatic Mapping and Sentinel Lymph Node (SLN) Biopsy in Patients With Stage I and II Malignant Melanoma
The purpose of this research study is to use two different drugs to find where melanoma might spread and to remove these tissues.
- Trial name
- NCT00847522
- Testing
- Fluorescein
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Utah
Prostate Cancer
A Phase 2 Study With MIP-1404 in Men With High-Risk PC Scheduled for RP and EPLND Compared to Histopathology
This was a multicenter, multi-reader, open-label, Phase 2 study assessing the safety and performance characteristics of MIP 1404 imaging in the detection of prostate gland and pelvic lymph node cancer.
- Trial name
- NCT01667536
- Testing
- Drug: 99mTc-MIP-1404
- Where
- 35 sites in United States, Belgium and 6 more
- Volunteers
- 105 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Endometrial Carcinoma
Improved Method of Detecting Cancer Metastases
The purpose of this study is to compare the Instillation Technique Using The Modified Intra- Uterine Manipulator Catheter With Methylene Blue, Isosulfan Blue or Indocyanine Green Dyes, Compared to Cervical Injection, For Sentinel…
- Trial name
- SITs (NCT02368067)
- Testing
- Standard of Care Sentinal Node Dye, Study Sentinal Node Dye
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southeastern Regional Medical Center
Breast Cancer
Axillary Lymph Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
The recently randomized trial (ASCOG Z0011) support that among patients with limited sentinel lymph node (SLN) metastatic breast cancer treated with breast conservation and systemic therapy, the use of sentinel lymph node biopsy…
- Trial name
- Z0011-China (NCT01796444)
- Testing
- Sentinel Lymph Node Biopsy, Intraoperative Pathological Examination, Axillary Lymph Node Dissection
- Where
- China
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer
Rationale and Trial Design of PFB-03 Study: Diagnostic Performance and Clinical Application of 18F-FAPI-PET/CT for Detecting Axillary Lymph Node Metastasis in Breast Cancer Patients After Neoadjuvant Therapy
Axillary lymph node (ALN) status is a crucial prognostic factor in breast cancer. Accurate, non-invasive methods for evaluating axillary lymph node metastasis after neoadjuvant therapy (NAT) are needed to optimize surgical…
- Trial name
- NCT07012707
- Volunteers
- 172 people
- Sponsor
- Peking Union Medical College Hospital
Metastatic Cancer
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates
Stereotactic ablative body radiotherapy (SABR) can be considered for patients with so-called "oligometastatic" disease. However, since this is a relatively new technique, information on the optimal scheduling is lacking.
- Trial name
- Destroy (NCT03486431)
- Testing
- Stereotactic Ablative Radiotherapy (SABR)
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Cancer Research Antwerp
Carcinoma, Lobular
Diagnostic Performance of [18F]FES PET/CT for Axillary LN Metastasis in Invasive Lobular Carcinoma
This study aims to explore the diagnostic validity of [18F]FES PET/CT for the evaluation of axillary lymph node metastasis in patients with invasive lobular breast cancer having clinically suspected or confirmed axillary lymph…
- Trial name
- NCT05960201
- Testing
- [18F]fluoroestradiol (FES)
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Asan Medical Center
Omitting Sentinel Lymph Node Biopsy in Early-stage Breast Cancer
De-escalation in Axillary Surgery for Early-stage Breast Cancer
The goal of this clinical trial is to determine if the omission of sentinel lymph node biopsy is safe for early-stage breast cancer patients in our institution (Clinical Hospital Centre Rijeka).
- Trial name
- RIDES (NCT07098507)
- Testing
- sentinel lymph node biopsy, omission of sentinel lymph node biopsy
- Where
- Croatia
- Volunteers
- 620 people
- Sponsor
- Clinical Hospital Center Rijeka
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Implementation of Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer
The goal of this clinical trial is to learn how to successfully introduce a new method for finding the sentinel lymph node during breast cancer surgery into routine hospital care.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INFINITE (NCT07146295)
- Testing
- Technetium (99mTc), Indocyanine Green, Sentinel lymph node biopsy
- Where
- 7 sites in Netherlands
- Volunteers
- 1,760 people
- Sponsor
- Isabelle Henskens
Sentinel Lymph Node, Breast Cancer
Carbon Dye Tattooing of Biopsied Axillary Node in Breast Cancer
The primary aim of this prospective, multicentre study is to determine whether the involved node can be marked using black carbon dye and successfully identified at the time of surgery.
- Conditions
- Sentinel Lymph Node, Breast Cancer, Tattoo; Pigmentation, Axilla; Breast
- Trial name
- pre-ATNEC (NCT03640819)
- Testing
- Tattooing of biopsied node
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer
VST-1001 (Dilute Fluorescein) for Lymphatic Mapping & Localization of Lymph Nodes in Patients With Breast Cancer
The purpose of this Phase 1 portion of this clinical research study is to find out what dose of dilute fluorescein is needed for a surgeon to best see important lymph nodes that need to be removed during surgery (a standard of…
- Trial name
- NCT02294565
- Testing
- VST-1001, 99mTc-labeled sulfur colloid
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Vestan, Inc.
Cervical Cancer
TMVP1-ICG Mapping in Laparoscopic SLN Detection in Cervical Cancer
Sentinel lymph node (SLN) mapping is an acceptable surgical strategy determine whether to perform radical lymphadenectomy in patients with early-stage cervical cancer.
- Trial name
- NCT03320772
- Testing
- TMVP1-ICG, ICG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Ovarian Cancer, Postoperative Complications
Systematic Lymphadenectomy During Interval Debulking Surgery in Advanced Epithelial Ovarian Cancer
The study aims to investigate the prognostic and postoperative complication relevance of lymphadenectomy in advanced epithelial ovarian cancer patients who received neoadjuvant chemotherapy (NACT) followed by interval debulking…
- Conditions
- Ovarian Cancer, Postoperative Complications, Neoadjuvant Therapy, Lymph Node Excision
- Trial name
- NCT06385912
- Testing
- lymphadenectomy
- Where
- China
- Volunteers
- 1,090 people
- Sponsor
- Tongji Hospital
Colorectal Cancer, Retroperitoneal Lymph Node Metastasis
CRT Versus Surgery for Retroperitoneal or Paraaortic Lymph Node Recurrence of CRC
The study aims to compare the effects of chemoradiation versus radical surgery in treating retro-peritoneal or para-aortic lymph node metastasis in colorectal cancer.
- Conditions
- Colorectal Cancer, Retroperitoneal Lymph Node Metastasis, Para-aortic Lymph Node Metastasis
- Trial name
- NCT03725254
- Testing
- lymphadenectomy, chemoradiotherapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fudan University
Breast Cancer Female
Effect of Quilting Sutures on Post-operative Drainage After Mastectomy and/or Axillary Lymph Node Dissection
Breast cancer is the most frequent type of cancer among Swiss women (5'700 cases diagnosed every year). Mastectomy is indicated when breast conservative surgery is not possible or by patient wish.
- Trial name
- Quilting (NCT03902977)
- Testing
- quilting, conventional suture
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Lindenhofgruppe AG
Melanoma
Multicenter Selective Lymphadenectomy Trial II (MSLT-II)
Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study requirements, the subject is randomized to receive either (1) completion…
- Trial name
- NCT00297895
- Testing
- Completion Lymphadenectomy, Monitoring with nodal ultrasound
- Where
- 63 sites in United States, Australia and 10 more
- Volunteers
- 1,939 people
- Sponsor
- Saint John's Cancer Institute
Rectal Cancer
Carbon Nanoparticles as Lymph Node Tracer in Rectal Cancer After Neoadjuvant Radiochemotherapy
The purpose of this study is to evaluate whether injection of carbon nanoparticle as a lymph node tracer before neoadjuvant radiochemotherapy in rectal cancer can increase lymph node yield after surgery compared which do not…
- Trial name
- CALOR-NAT (NCT03550001)
- Testing
- Injection CNP before NAT
- Volunteers
- 252 people
- Sponsor
- YE Yingjiang
Non Small Cell Lung Cancer
Evaluation of Lymph Node Analysis Using One Step Nucleic Acid Amplification (OSNA) in Patients With Lung Cancer Who Underwent Robotic Lung Resection, Comparison With Traditional Methods
This prospective study aims to evaluate the effectiveness of the One-Step Nucleic Acid Amplification (OSNA) technique for detecting micrometastases in lymph nodes of patients with clinical stage I-II non-small cell lung cancer…
- Trial name
- LALC (NCT07301983)
- Testing
- lymph node analysis using the OSNA assay
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Breast Carcinoma
3D Ultrasound for the Imaging of Lymph Nodes in Patients With Breast Cancer
This early phase I studies how well a new 3D ultrasound (3D-US) imaging technology works in evaluating lymph nodes in patients with breast cancer. Ultrasound uses high-frequency sound waves to generate images of the body.
- Trial name
- NCT05704283
- Testing
- Ultrasound Imaging
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Mayo Clinic
Colon Cancer, Colon Adenocarcinoma
Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma
The aim of this study is to reduce the need for colectomy and its' associated morbidity and mortality in patients with pT1-2 colon carcinoma after endoscopic resection and an estimated lymph node metastasis (LNM) risk of >15%, or…
- Conditions
- Colon Cancer, Colon Adenocarcinoma, Sentinel Lymph Node, Sentinel Lymph Node Biopsy
- Trial name
- SENTRY (NCT06652672)
- Testing
- Organ-sparing surgery, Standard of care segmental resection
- Where
- Netherlands
- Volunteers
- 341 people
- Sponsor
- Meander Medical Center
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