Clinical trials: Lymph Node Neoplasm, open to volunteers
Lung Neoplasms, Pulmonary Neoplasms
Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy
In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered…
- Conditions
- Lung Neoplasms, Pulmonary Neoplasms, Lymph Node Involvement, Pulmonary Nodule
- Trial name
- DEFLECT I (NCT06809946)
- Testing
- injection with 15 mg bevacizumab-800CW before bronchoscopy, injection with 25 mg bevacizumab-800CW before bronchoscopy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Breast Cancer
Carbon Suspension vs. Metallic Marker for Axillary Lymph Node Marking in Breast Cancer After Neoadjuvant Therapy
This single-center, randomized study aims to compare the intraoperative detection rates of axillary lymph nodes marked with carbon suspension versus metallic markers in breast cancer patients (T1-3N1M0) before neoadjuvant…
- Trial name
- COMET (NCT07106112)
- Testing
- Ultrasound-guided carbon suspension (Black Eye) injection, Ultrasound-guided metallic marker (TWIRL ULTRACOR) placement
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Saint Petersburg State University, Russia
Testicular Cancer
A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Testicular cancer represents 1% of adult neoplasms and is the most common solid malignancy in young men. At diagnosis, approximately 90% of cases are germ cell tumours (GCT), categorised as either seminoma (55-60%) or…
- Trial name
- RPLND-Seminoma (NCT06932458)
- Testing
- Retroperitoneal Lymph Node Dissection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Breast Cancer
Evaluate the Implementation of Using Indocyanine Green for Sentinel Lymph Node Mapping in Breast Cancer Patients
This single-institution pilot study uses a pre- and post-implementation design to evaluate the implementation of ICG fluorescent imaging for sentinel lymph node biopsy (SLNB) in an Italian hospital.
- Trial name
- INFLUENCE II (NCT07441733)
- Testing
- ICG used as a tracer for sentinel lymph node, technetium 99 used as a tracer for sentinel lymph node
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Breast Cancer, Sentinel Lymph Node
Application of EndoScell Intraoperative Cellular Probing Technology for Early-Stage Breast Cancer
Sentinel Lymph Node Biopsy (SLNB) is a common surgical treatment for breast cancer and a primary method for assessing the pathological status of axillary lymph nodes.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Frozen Section, Cytology
- Trial name
- EDGE (NCT06911528)
- Testing
- EndoScell Scaner (ES) novel intraoperative cellular probing technology
- Where
- China
- Volunteers
- 709 people
- Sponsor
- Fudan University
Mouth Neoplasms, Oral Cancers
Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative
The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers.
- Conditions
- Mouth Neoplasms, Oral Cancers, Oral Squamous Cell Carcinoma (OSCC), Oral Squamous Cell Carcinomas
- Trial name
- SECOND N0 (NCT05774483)
- Testing
- Sentinel Node Biopsy, Limited Elective Neck Dissection
- Where
- 3 sites in India
- Volunteers
- 508 people
- Sponsor
- Tata Memorial Hospital
Breast Cancer
Adjuvant Study of Pyrotinib in Combination With Trastuzumab in HER2 Positive Invasive Breast Cancer
This is an open label, phase III study evaluating the efficacy and safety of Pyrotinib in Combination With Trastuzumab and paclitaxel in patients HER2 Positive and lymph node negative invasive Breast Cancer
- Trial name
- NCT05841381
- Testing
- Pyrotinib, Trastuzumab, Paclitaxel
- Volunteers
- 876 people
- Sponsor
- Fudan University
Breast Cancer Metastatic, Sentinel Lymph Node
Rapid Assessment of Sentinel Lymph Node Metastasis Status Using a Pan-CK-targeting NIR-II Fluorescent Probe in Breast Cancer
Breast malignant tumors are a serious threat to women's health, and the current treatment for breast malignant tumors is still dominated by surgery, but the problems faced by patients after surgery such as edema and tumor…
- Conditions
- Breast Cancer Metastatic, Sentinel Lymph Node, Sentinel Lymph Node Biopsy (SLNB), Metastasis
- Trial name
- NIR-II (NCT07154563)
- Testing
- NIR-II probe (i.e ICG-CK) incubation solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yunnan Cancer Hospital
Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB)
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in IBC
This study will prospectively determine the feasibility and oncological safety of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in inflammatory breast cancer patients traditionally considered ineligible…
- Conditions
- Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB), Neoadjuvant Chemotherapy
- Trial name
- SYMPHONY (NCT07080944)
- Testing
- SLN identification using technetium-99m, SLN intra-operatory identification with radioguided surgery, Axillary Limph Node Dissection (ALND)
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- European Institute of Oncology
Colorectal Neoplasms, Stomach Neoplasms
SND002 Cell Injection in Participants With Advanced Malignant Solid Tumors
This is a phase 1, multicenter, open-label, single-arm study evaluating SND002 Cell Injection in participants with advanced malignant solid tumors that have progressed after standard treatment or for whom no standard treatment is…
- Conditions
- Colorectal Neoplasms, Stomach Neoplasms, Solid Tumor Malignancies
- Trial name
- NCT07903857
- Testing
- SND002 Cell Injection
- Where
- 2 sites in China
- Volunteers
- 78 people
- Sponsor
- Guizhou Sinorda Pharmaceutical Co., Ltd.
Lymph Nodes, Peritoneal Tumour
Histotripsy for Peritoneal Tumour and Lymph Node: a Pilot Study
Peritoneal cancer is tricky to be managed. It is not easy to be detected or diagnosed at early stage without symptom, or with common symptoms of many diseases or discomfort and often leads to advance stage at time of diagnosis…
- Trial name
- NCT07873619
- Testing
- Histotripsy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC))
Use of Magtrace Bracketing for Excision of Lesion and Sentinel Lymph Node Localization in Breast Conserving Surgery for Breast Cancer
Breast cancer is the commonest cancer affecting women worldwide. Early breast cancer is treated surgically with wide local excision of tumor with axillary staging operations like sentinel node biopsy.
- Conditions
- Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer (Triple Negative Type), Breast Cancer - Infiltrating Ductal Carcinoma
- Trial name
- MagBracket (NCT07844473)
- Testing
- Super paramagnetic iron oxide bracketing injection
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer, Neoadjuvant Therapy
No Axillary Surgical Treatment in Clinically Lymph Node Negative Patients on Ultrasonography After Neoadjuvant Chemotherapy
NEO-NAUTILUS is a prospective, multicenter, randomized phase III clinical trial to evaluate whether omitting axillary lymph node surgery (ALND or SLNB) in clinically lymph node-negative breast cancer patients after neoadjuvant…
- Conditions
- Breast Cancer, Neoadjuvant Therapy, Sentinel Lymph Node Biopsy
- Trial name
- Neo-NAUTILUS (NCT06704945)
- Testing
- No axillary surgery, Axillary surgery
- Where
- South Korea
- Volunteers
- 464 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Magseed Pro(R)/ Sentimag(R) Gen3
The purpose of this study is to provide prospective evidence that the Magseed Pro® marker /Sentimag® Gen3 system is safe and effective for marking A. suspicious/biopsy-proven positive axillary lymph nodes; and B.
- Trial name
- NCT05142787
- Testing
- Magseed Pro(R) and Sentimag(R) Gen3 by Endomagnetics
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 224 people
- Sponsor
- Endomagnetics Ltd.
Gynecologic Cancer, Cervical Cancer
Intraoperative Microscopic Assessment of Lymph Node Status in Gynecological Malignancies
The IMAGINE study is a monocentric, observational, prospective study evaluating the diagnostic performance of Full-Field Optical Coherence Tomography (FF-OCT) combined with Dynamic Cell Imaging (DCI) (Van Gogh System, AQUYRE…
- Conditions
- Gynecologic Cancer, Cervical Cancer, Endometrial Cancer, Ovary Cancer
- Trial name
- IMAGINE (NCT07702721)
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer-Related Lymphedema, Lymphedema
Supermicrosurgical Lymphaticovenous Anastomosis for Prevention of Upper Limb Lymphedema
Breast cancer-related lymphedema (BCRL) is one of the most common chronic complications following breast cancer treatment. This study enrolls breast cancer patients who are required to undergo axillary lymph node dissection and…
- Conditions
- Breast Cancer-Related Lymphedema, Lymphedema, Breast Cancer Invasive
- Trial name
- SLVA-PULL (NCT07026292)
- Testing
- Immediate Distal Lymphaticovenous Anastomosis (ID-LVA)
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pediatric Solid Tumors, Rhabdomyosarcoma
Tumor-Lymph Node Mapping
The purpose of this study is to assess the feasibility and safety of ICG-guided intraoperative lymphography for detecting sentinel lymph nodes (SLN) in pediatric patients with solid tumors who require retroperitoneal lymph node…
- Conditions
- Pediatric Solid Tumors, Rhabdomyosarcoma, Sarcoma, Germ Cell Tumor
- Trial name
- T-LyM (NCT07054944)
- Testing
- ICG (Indocyanine Green)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial…
- Trial name
- NCT05646316
- Testing
- Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy
- Where
- 60 sites in United States, South Korea
- Volunteers
- 428 people
- Sponsor
- NRG Oncology