Clinical trials: Lymph Node Neoplasm
ALND, Sentinel Lymph Node Biopsy (SLNB)
Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement
The present study aims to avoid axillary lymph node dissection (ALND) in patients with an Ultrasound (US) detected positive preoperative lymph node involvement (1 or 2 suspicious lymph-nodes) and a needle histology/cytology…
- Conditions
- ALND, Sentinel Lymph Node Biopsy (SLNB), Targeted Axillary Dissection (TAD)
- Trial name
- UTAD (NCT07278726)
- Testing
- Upfront Targeted Axillary Dissection (UTAD)
- Where
- 14 sites in Italy, Switzerland
- Volunteers
- 150 people
- Sponsor
- European Institute of Oncology
Pancreatic Disease, Pancreatic Cancer
EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
This is a randomized trial to compare the standard echoendoscope with the newly developed EndoSound Visual System in the evaluation of lesions in the gastrointestinal tract.
- Conditions
- Pancreatic Disease, Pancreatic Cancer, Pancreatic Cyst, Gastrointestinal Tumor
- Trial name
- NCT06340620
- Testing
- Endoscopic ultrasound examination
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Orlando Health, Inc.
Breast Cancer, Sentinel Lymph Node
Indocyanine Green Fluorescence-guided Sentinel Node Biopsy in Breast Cancer Within a North African Population: a Retrospective Study
Background Radio Isotopes and Blue dye alone or in combination are the most commonly used tracer agents in sentinel Node Biopsy for early breast cancer.
- Trial name
- NCT04879680
- Testing
- sentinel node detection
- Volunteers
- 47 people
- Sponsor
- Faculty of Medicine, Sousse
Breast Cancer, Estrogen-receptor-positive Breast Cancer
Electronic Medical Record-Based Nudge to Reduce SLNB
The goal of this prospective, historically-controlled, quality improvement project is to determine whether and to what extent an electronic health record (EHR)-based nudge affects rates of sentinel lymph node biopsy (SLNB) in…
- Trial name
- NCT06006910
- Testing
- Column-based nudge in the EHR, No column-based nudge in the EHR
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh Medical Center
Esophageal Cancer, Adenocarcinoma of the Esophagus
Total Neoadjuvant Therapy for Lymph Node-positive Adenocarcinoma of the OESophagus and Oesophagogastric Junction
Both neoadjuvant chemoradiotherapy (CROSS) and neoadjuvant chemotherapy (FLOT) have demonstrated overall survival benefit over surgery alone in esophageal and esophagogastric junction (EGJ) cancer.
- Trial name
- TNT-OES-2 (NCT06161818)
- Testing
- FLOT-CROSS or CROSS-FLOT
- Where
- 10 sites in Netherlands
- Volunteers
- 216 people
- Sponsor
- Erasmus Medical Center
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy With Modified Injection Technique
Internal Mammary Lymph Node (IMLN) and Axillary Lymph Node (ALN) are regarded as "the first station" of lymphatic drainage in breast cancer, serving as an important reference for lymph staging and decision-making.
- Trial name
- NCT03541278
- Testing
- MIT, IM-SLNB
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong Cancer Hospital and Institute
Vulvar Cancer
Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients.
The purpose of this study is to evaluate a less invasive procedure for the evaluation of the inguinal (groin) nodes in patients with a primary squamous cell carcinoma of the vulva.
- Trial name
- NCT00315159
- Testing
- Sentinel Node Biopsy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Bladder Cancer
Early Versus Late FDG-PET/CT in Bladder Cancer
The aim of this study is to examine if late FDG-PET/CT images after intravenous FDG injection has a higher sensitivity and specificity in detecting local lymph node metastases in patients with muscle invasive BC than FDG-PET/CT…
- Trial name
- NCT03065725
- Testing
- late FDG
- Where
- 2 sites in Denmark
- Volunteers
- 179 people
- Sponsor
- Jørgen Bjerggaard Jensen
Breast Cancer
Prospective Evaluation of Targeted Axillary Dissection (TAD)
The purpose of this research is to evaluate how to manage the axillary lymph nodes in patients with breast cancer. The investigators will determine if a sampling of the lymph nodes under the arm will give the information…
- Trial name
- TAD (NCT04998682)
- Testing
- Axillary Dissection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Esophageal Cancer
Two-field Versus Three-field Lymphadenectomy in Thoracic Esophageal Carcinoma Without Cervical Lymph Node Involvement
The purpose of this study is to compare the lymph node dissection results and prognosis in thoracic esophageal carcinoma patients without cervical lymph node involvement by preoperative CT and/or ultrasound treated by two-field…
- Trial name
- NCT02448953
- Testing
- Two-field lymphadenectomy, Three-field lymphadenectomy
- Where
- China
- Volunteers
- 786 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Neoplasms
Preventing Seroma Formation After Axillary Lymph Node Dissection for Breast Cancer by Early Vacuum Assisted Closure
Axillary dissection is the standard treatment for breast cancer patients with positive nodes. However, seroma formation after axillary dissection remains the most common early complication to breast cancer surgery.
- Trial name
- NCT01731769
- Testing
- vacuum assisted closure in experimental arm, Axillary dissection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Changhai Hospital
Breast Carcinoma
Quality of Life, Employment, and Informal Care Costs in Women Who Are Receiving Chemotherapy for Breast Cancer
This research trial studies quality of life, employment, and informal care cost analysis in patients with breast cancer receiving chemotherapy.
- Trial name
- NCT00115505
- Testing
- quality-of-life assessment, Questionnaire Administration
- Where
- 227 sites in United States
- Volunteers
- 307 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Intrahepatic Cholangiocarcinoma, Machine Learning
A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma
The object of this study is to develop a model for prediction of lymph node metastasis among intrahepatic cholangiocarcinoma (ICC) patients.
- Trial name
- NCT06290739
- Testing
- lymph nodes dissection
- Where
- China
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Prostate Cancer
Pilot Study of 99mTc-MIP-1404 SPECT/CT Imaging in Men With Prostate Cancer Undergoing Prostatectomy and/or Pelvic Lymph Node Dissection
This is a single arm, open label study of up to 24 high risk prostate cancer patients scheduled for prostatectomy and/or pelvic lymph node dissection.
- Trial name
- NCT01572701
- Testing
- 99mTc-MIP-1404
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Adenocarcinoma of the Prostate
A Study of VEGF Tyrosine Kinase Inhibitor (Pazopanib) in Men With High-Risk Prostate Cancer Followed by Radical Prostatectomy and Pelvic Lymph Node Dissection
The area around a tumor ("pre-metastatic niche") may be an area to which cancer cells are attracted. The study doctor will take blood and tumor samples to look for certain features linked with response to treatment so that they…
- Trial name
- NCT01832259
- Testing
- Pazopanib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Pancreatic Cancer
Systematic Lymph Node Sampling and Analysis in Patients With Pancreatic Cancer
Prospective investigation of the ratio between malignant and total number of lymph nodes in predefined lymph node stations in patients resected for pancreatic adenocarcinoma. A national Danish project.
- Trial name
- NCT02646462
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Michael Bau Mortensen
Early Breast Cancer
Refusal of Sentinel Lymph Node Biopsy in Patients With Luminal A Subtype Early Breast Cancer
Sentinel lymph node biopsy (SLNB) is the standard of axillary lymph node surgical staging in patients with early breast cancer. The main goal of the study is to abandon axillary surgery in patients over 59 years old with early…
- Trial name
- LumiNOde (NCT07579286)
- Testing
- breast resection, Breast resection with sentinel lymph node biopsy
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Early Stage Endometrial Cancer, Sentinel Lymph Nodes
Sentinel Lymph Node Biopsy Versus Lymphadenectomy in Endometrial Cancer
To compare sentinel lymph nodes biopsy versus comprehensive lymphadenectomy in patients with early stage endometrial cancer.
- Conditions
- Early Stage Endometrial Cancer, Sentinel Lymph Nodes, Lymphadenectomy
- Trial name
- NCT05048173
- Testing
- Sentinel lymph node mapping and biopsy, Lymphadenectomy
- Where
- Taiwan
- Volunteers
- 334 people
- Sponsor
- Far Eastern Memorial Hospital
Carcinoma, Non-small Cell Lung Cancer
Anatomical Location and Metastasis Pattern of Intrapulmonary Lymph Nodes in NSCLC (ECTOP-1010)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1010. Anatomical Location and Metastasis Pattern of Intrapulmonary Lymph Nodes (Group 11-13) in Non-small Cell Lung Cancer: a…
- Trial name
- NCT05094882
- Testing
- pulmonary lobectomy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fudan University
Breast Cancer
Randomized Phase III Trial Comparing Sequential Administration of FE75C Followed by Docetaxel Versus Paclitaxel as Adjuvant Chemotherapy in Axillary Lymph Node (+) Breast Cancer
Anthracycline-containing regimens are recommended as adjuvant treatment for women with node positive breast cancer. In at least three large randomized clinical trials the addition or sequential administration of a taxane…
- Trial name
- NCT00431080
- Testing
- Docetaxel, Paclitaxel, Epirubicin
- Where
- 10 sites in Greece
- Volunteers
- 478 people
- Sponsor
- Hellenic Oncology Research Group