Clinical trials: Lymph Node Neoplasm
Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate
RYZ711 Diagnostic Platform Study
This is a Phase 1/2 multicenter, multi-cohort imaging study to evaluate the safety, tolerability, and diagnostic performance of RYZ711 positron emission tomography/computed tomography (PET/CT) in men with histologically confirmed…
- Conditions
- Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate, Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT07862582
- Testing
- RYZ711, PSMA PET/CT
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- RayzeBio, Inc.
Breast Cancer, Inflammatory Breast Cancer
Refining Local-Regional Therapy for IBC
This Feasibility study is trying to determine: If Lymphoscintigraphy (imaging of the lymphatic drainage patterns) is effective in demonstrating the drainage to the sentinel lymph nodes in patients with inflammatory breast cancer.
- Conditions
- Breast Cancer, Inflammatory Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT04636710
- Testing
- Lymphoscintigraphy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer by AJCC V8 Anatomic Stage, Breast Cancer
De-escalation of Axillary Dissection for Node-positive Breast Cancer
Recent studies have demonstrated the safety of de-escalation of nodal surgery for clinically node-positive breast cancer patients after a favorable response to neoadjuvant systemic therapy (NST).
- Trial name
- NCT07856160
- Testing
- TAD+ALND
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Multiple Myeloma, Breast Cancer
Efficacy of Gamma Camera Used Intraoperatively for ID of Sentinel Lymph Nodes w/ Lymphoscintigraphy
This study evaluates the ability of a prototype intraoperative handheld gamma camera (pIHGC) to image (detect) sentinel lymph nodes (SLNs) in melanoma and breast cancer during surgical excision, as compared to standard of care…
- Trial name
- NCT01314963
- Testing
- Prototype intraoperative handheld gamma camera (pIHGC), Lymphoscintigraphy with intraoperative gamma probes (GP), radioactive Tc99M
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Thyroid Carcinoma, Surgery
Thyroid Cancer and Central Lymph Node Metastases Detection Using Bevacizumab-IRDye800CW
Background: Papillary thyroid cancer (PTC) patients often develop central lymph node metastases (CLNM), which pose a high risk of disease recurrence.
- Trial name
- TARGET-beva (NCT06095362)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Postoperative Recovery
ERAS Protocols in Breast Conserving Surgery
Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of…
- Trial name
- ERAS (NCT06938581)
- Testing
- ERAS Protocol, Standard Perioperative Care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Nebraska
Differentiated Thyroid Cancer (DTC), Robotic Assistance
Robotic Surgery Via Bilateral Axillo-breast Approach for Relatively Low-risk Papillary Thyroid Carcinoma With Lateral Cervical Lymph Node Metastasis: a Safe and Effective Cosmetic Procedure in the Context of Prevalent Thyroid Ultrasound Screening
The goal of this observational study is to learn the efficacy, cosmetic effectiveness and safety of robotic modified radical neck dissection in well-selected cases, through direct comparison with conventional open surgery in…
- Trial name
- NCT07229859
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Ruijin Hospital
Gastric Cancer, Esophageal Cancer
Magnetic Sentinel Lymph Node Mapping in Upper Gastro-Intestinal Cancer: A Feasibility Clinical Investigation
This is a multi-centre, partially blinded, side-by-side comparator study to assess the safety and tolerability, feasibility, and potential added diagnostic and clinical value of using the FerroTrace® and FerroMag Sentinel Lymph…
- Trial name
- MAGMAP (NCT05899985)
- Testing
- FerroTrace® and FerroMag Sentinel Lymph Node Mapping (SLNM) System
- Where
- 4 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Ferronova Pty Ltd
Multimodal Ultrasonographic Assessment of Axillary Lymph Nodes in Patients With Breast Cancer
Multimodal Ultrasonographic Assessment of Ipsilateral Axillary Lymph Nodes in Patients With Breast Cancer: A STARD Study
Breast cancer (BrCa) is the most common malignant neoplasm in women worldwide with a continuous rise on both its incidence and cancer-related deaths.
- Trial name
- NCT04549558
- Testing
- Multimodal Ultrasound
- Volunteers
- 30 people
- Sponsor
- Assiut University
Breast Neoplasm
Ultrasonographic Axillary Localization
Breast cancer is the most common cancer of women. Surgery for early breast cancer includes axillary lymph nodes staging. Axillary surgery may lead to intractable complications like permanent arm swelling.
- Trial name
- NCT04644848
- Testing
- Ultrasonographical tattooing of suspicious axillary lymph nodes., Sentinel lymph node biopsy, Histopathological examination of the axillary nodes
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Mansoura University
Follicular Lymphoma
CD180 Overexpression in Follicular Lymphoma
Background:Altered Toll-like receptor (TLR) expression levels and/or mutations in its signaling pathway (such as MyD88 mutation) contribute to the pathogenesis of lymphoproliferative disorders (LPD).
- Trial name
- NCT02978898
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Breast Cancer Female
Partial Chest Wall Radiation Therapy After Surgery for Lymph Node Negative Breast Cancer
The standard treatment for breast cancer when cancer cells were found near or within the margins of the tissue that is removed during breast surgery, is radiation of the entire chest wall.
- Conditions
- Breast Cancer, Breast Cancer Female, DCIS, Stage II Breast Cancer
- Trial name
- NCT05436808
- Testing
- Partial Chest Wall Radiation Therapy
- Where
- United States
- Sponsor
- Stony Brook University
Endometrial Cancer, Vulvar Cancers
The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer
This research will determine the impact of optimizing dosage and storage conditions for indocyanine green on health outcomes and will contribute to improving treatment processes in gynecological cancers.
- Conditions
- Endometrial Cancer, Vulvar Cancers, Cervical Cancer, Indocyanine Green (ICG)
- Trial name
- DOSTCONICG (NCT07380698)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Malignant Melanoma
Suction Drain in Axillary Lymph Node Dissection for Malignant Melanoma
Postoperative complications like seroma formation and wound site infection readily occur following completion axillary lymph node dissection (ALND) for malignant melanoma.
- Trial name
- NCT04648163
- Where
- Austria
- Volunteers
- 118 people
- Sponsor
- Medical University of Graz
Cervical Cancer, Sentinel Lymph Node
HPV in Sentinel Lymph Nodes of Cervical Cancer Patients
This study examines sentinel lymph node tissue from early stage cervical cancer patients treated with radical surgery and removal of pelvic sentinel lymph nodes (SLN).
- Conditions
- Cervical Cancer, Sentinel Lymph Node, HPV-Related Cervical Carcinoma
- Trial name
- NCT03749707
- Testing
- HPV analysis
- Where
- Denmark
- Volunteers
- 127 people
- Sponsor
- University of Aarhus
Colorectal Cancer
Early Lymph Node Metastasis in T1/2 Stage Colorectal Cancer: Molecular and Clinical Insights
The prognostic implications of lymph node metastasis in colorectal cancer patients at an early stage, specifically T1/2 stage, are relatively unfavorable.
- Trial name
- NCT06130644
- Volunteers
- 1,451 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Breast Cancer
Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy
This research protocol is studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine…
- Trial name
- NCT02752009
- Testing
- Axillary Lymph Node Sampling Clip
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Sentinel Lymph Node Total Tumoral Load as a Predictor of Non Sentinel Node Involvement in Early Breast Cancer
This is a retrospective, multicentric cohort study of patient cases with cT1-3, N0 early breast cancer, who previously had intraoperative sentinel lymph node (SLN) evaluation by one-step nucleic acid amplification (OSNA) assay…
- Trial name
- SOLO-1 (NCT01669265)
- Where
- 9 sites in Spain
- Volunteers
- 701 people
- Sponsor
- SOLTI Breast Cancer Research Group
Pediatric Solid Tumors, Rhabdomyosarcoma
Tumor-Lymph Node Mapping
The purpose of this study is to assess the feasibility and safety of ICG-guided intraoperative lymphography for detecting sentinel lymph nodes (SLN) in pediatric patients with solid tumors who require retroperitoneal lymph node…
- Conditions
- Pediatric Solid Tumors, Rhabdomyosarcoma, Sarcoma, Germ Cell Tumor
- Trial name
- T-LyM (NCT07054944)
- Testing
- ICG (Indocyanine Green)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Sentinel Lymph Node Biopsy (SLNB), Melanoma (Skin Cancer)
Evaluating a Decision Aid for Sentinel Lymph Node Biopsy in Intermediate-Risk Melanoma
This research study is testing a decision aid to help patients think through whether to have sentinel lymph node biopsy for melanoma.
- Trial name
- Mel73 (NCT07653087)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Virginia
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