Clinical trials: Lymph Node Neoplasm
Breast Cancer
Fluorescein for Sentinel Lymph Node Biopsy (SLNB) in Breast Cancer
The study goal is to develop a new method of intraoperative lymphatic mapping with fluorescent contrast agents to improve the outcome of therapeutic breast cancer surgery.
- Trial name
- NCT01614184
- Testing
- Fluorescein
- Sponsor
- University of Utah
Renal Cell Carcinoma (RCC)
Investigation of Lymph Node Biology in Kidney Cancer
The purpose of this pilot study is to investigate the phenotype, anti-tumor effector functions, and TCR repertoire of T cells isolated from patient tumor draining lymph nodes (TDLNs) to understand T cell priming and trafficking…
- Trial name
- LN-RCC (NCT07038733)
- Testing
- Peripheral Blood Sample for Immune Analysis, Tumor Sample for Analysis, Adjacent non-malignant kidney for analysis
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yale University
Gastric Cancer
Spectral CT Combined With MSI for Predicting Regional Lymph Node Metastasis in Gastric Cancer
This study prospectively collected spectral CT imaging data and clinical information related to gastric cancer, evaluated the diagnostic efficacy of its image quality for regional lymph nodes in gastric cancer, and explored its…
- Trial name
- NCT07565818
- Testing
- o explore the value of spectral CT in the diagnosis and treatment of gastric cancer with different MSI statuses
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Yunnan Cancer Hospital
Head and Neck Neoplasms
Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
Cervical lymph node involvement, in head and cancer neck patients, is one of the most important prognostic factors. Currently patients undergo neck dissection removing some or all nodes and neck involvement is retrospectively…
- Trial name
- SLN Mapping (NCT02478138)
- Testing
- Sentinel lymph node mapping, Indocyanine Green (ICG), near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Head and Neck Cancer
Lymph Node Assessment Using Simultaneous 18F-FDG-PET and MRI
The overarching goal of this study is to develop PET/MR techniques to accurately detect nodal metastases for surgical planning and assessment of treatment response.
- Trial name
- NCT02180308
- Testing
- PET/MRI
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- NYU Langone Health
Colon Cancer Stage III
Lymph Node Ratio and Kras Mutation in R Colon Cancer
clinical impact of LN ratio with Kras expression in colon cancer
- Trial name
- NCT04342676
- Testing
- k ras, Panitumumab
- Where
- Egypt
- Volunteers
- 433 people
- Sponsor
- Mansoura University
Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher
Diagnostic Accuracy of MRI, DWI MRI, FDG-PET/CT and FEC PET/CT in the Detection of Lymph Node Metastases in Surgically Staged Endometrial and Cervical Carcinoma
This is a prospective diagnostic performance study which compares three new imaging methods with the current standard imaging method for the diagnosis of metastatic lymph nodes.
- Conditions
- Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher, Endometrial Cancer, Stage 1A With Myometrial Invasion or Any Higher Stage and Grade 3
- Trial name
- MAPPING (NCT01836484)
- Testing
- Diffusion-weighted MRI, Fluorodeoxyglucose-18-PET/CT, Fluoro-ethyl-coline-PET/CT
- Where
- 7 sites in United Kingdom
- Volunteers
- 162 people
- Sponsor
- Barts & The London NHS Trust
Endometrial Cancer
SLNM in Endometrial Cancer Combined With OSNA
The aim of the study is to compare one-step nucleic acid amplification method (OSNA) with histological ultrastaging examination in the sentinel lymph node assessment in patients with endometrial cancer.
- Trial name
- SLNM/OSNA (NCT02826291)
- Testing
- RD-100i, OSNA
- Where
- Czechia
- Volunteers
- 58 people
- Sponsor
- Charles University, Czech Republic
Sentinel Lymph Node Biopsy, Neoadjuvant Therapy
Clinical Application of Multi-modal Sentinel Lymph Node Staining Method in Breast Cancer Patients After Neoadjuvant Chemotherapy
This clinical trial aimed to confirm the effectiveness of sentinel lymph node surgery by determining the lymph node identification rate using multimodal sentinel lymph node marker methods in patients with advanced breast cancer…
- Conditions
- Sentinel Lymph Node Biopsy, Neoadjuvant Therapy, Breast Neoplasm
- Trial name
- NCT06212440
- Testing
- Radioactive Isotope (RI) Mapping, Indocyanine Green Fluorescence (ICG-F) Mapping, Vital Dye Mapping
- Where
- 2 sites in South Korea
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Tumors of the Pancreas, Submucosal Tumor of Gastrointestinal Tract (Disorder)
Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®)
The present study investigates the efficacy of a new Endoultrasound guided fine needle biopsy (EUS-FNB) device (AquireTM Boston Scientific= AQUIRE®) for obtaining histological tissue cylinders in the diagnosis of solid pancreatic…
- Conditions
- Tumors of the Pancreas, Submucosal Tumor of Gastrointestinal Tract (Disorder), Lymph Node Disease
- Trial name
- NCT03621852
- Testing
- Endoultrasound guided FNB
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Philipps University Marburg
Breast Cancer
Dalpicilib-Enhanced vs. Standard Endocrine Therapy in ER+ HER2- Early Breast Cancer
This study aims to conduct a randomized controlled clinical trial to compare the efficacy and safety of dalpicilib combined with endocrine therapy versus standard endocrine therapy in ER-positive, HER2-negative, lymph…
- Trial name
- NCT06637150
- Testing
- Dalpicilib, endocrine therapy
- Where
- China
- Volunteers
- 1,388 people
- Sponsor
- Fudan University
Small Bowel Cancer, Small Bowel Carcinoid Tumor
Surgery With Extended (D3) Mesenterectomy for Small Bowel Tumors
The study is designed to investigate the safety and efficacy of central D3 lymphadenectomy in cases of small bowel tumors. Such dissection is under debate; consensus guidelines are vague when it comes to surgical techniques and…
- Conditions
- Small Bowel Cancer, Small Bowel Carcinoid Tumor, Quality of Life, Lymph Node Metastases
- Trial name
- NCT05670574
- Testing
- Surgery with extended (D3) mesenterectomy for small bowel tumors
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset i Vestfold HF
Seroma
Extended-release of Octreotide (LF-PB) for the Treatment of Seroma
This is a multicentre, double blind, randomized placebo controlled trial to assess the effect of LF-PB on seroma formation in women with breast cancer undergoing Axillary Lymph Node Dissection (ALND).
- Trial name
- NCT02668588
- Testing
- extended release of octreotide
- Where
- 7 sites in Italy
- Volunteers
- 48 people
- Sponsor
- Chemi S.p.A.
Prostate Cancer
Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer
This study aims to evaluate patients with metastatic castrate-resistant prostate cancer (mCRPC) undergoing treatment with sipuleucel-T for evidence of treatment-associated immune activation in lymph nodes and peripheral blood.
- Trial name
- NCT02036918
- Testing
- Sipuleucel-T, Lymph Node Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Carcinoma, Non-Small Cell Lung
Endobronchial Ultrasound- Transbronchial Needle Aspiration (EBUS-TBNA) Versus Mediastinoscopy for Mediastinal Lymph Node Staging of Non-small Cell Lung Cancer (NSCLC)
Accurate staging of the mediastinum is essential to evaluate prognosis in non-small cell lung cancer and to devise an appropriate treatment plan.
- Trial name
- NCT01079520
- Testing
- Endobronchial ultrasound (EBUS), Mediastinoscopy
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Effect of CNSI vs. ICG in Lymph Node Tracing During Gastrectomy
The purpose of this study is to assess the efficacy and safety of carbon nanoparticle suspension injection and indocyanine green tracer-guided lymph node dissection during gastrectomy in patients with gastric cancer
- Trial name
- FUTURE-01 (NCT05229874)
- Testing
- carbon nanoparticles, Indocyanine green
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Hebei Medical University
Sentinel Lymph Node Biopsy, Colon Cancer
Comparison Between ex Vivo and in Vivo Injection of Blue Dye in Sentinel Lymph Node Mapping for Colon Cancer
The technique of sentinel lymph node mapping in patients with colon cancer varies among reports, and the optimal method remain to be established.
- Trial name
- NCT00654342
- Testing
- Intraoperative injection (in vivo), Postoperative injection (ex vivo)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chung-Ang University
Lung Cancer
Olympus - 19-gauge Needle
The purpose of this study is to test whether the 19-gauge needle can collect more tissue and get better sampling during a bronchoscopy procedure.
- Trial name
- NCT03270670
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Rectal Cancer
Lateral Lymph Node Dissection for Middle-low Rectal Cancer
The investigators will perform CT three-dimension reconstruction for middle-low rectal cancer patients who have enlarged lateral lymph nodes to recognize the variance of pelvic vessels, by which to help reduce operative time and…
- Trial name
- NCT03826862
- Testing
- CT three-dimensional reconstruction
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ziqiang Wang,MD
Breast Neoplasms
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer
RATIONALE: Patients with HER2-negative breast cancer not responding to initial neoadjuvant chemotherapy might have lower chances for a pathologic complete response (pCR) at definitive surgery, indicating worse prognosis.
- Trial name
- NCT06121570
- Testing
- Sentinel Lymph Node Biopsy (SLNB), Doxorubicin, Epirubicin
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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