Clinical trials: Lymph Node Neoplasm
Breast Cancer
Breast Cancer: Axillary Conservation After Neoadjuvant Chemotherapy in Micro Metastatic Sentinel Lymph Nodes.
Italian multicentric non inferiority clinical study to verify whether the omission of axillary lymph node intervention in patients with SLN (Sentinel Lymph Nodes) ypN1mi after NAC (Neo Adiuvant Chemotherapy) does not lead to a…
- Trial name
- NEONOD2 (NCT04019678)
- Testing
- Omission of Axillary dissection
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Istituto Clinico Humanitas
Esophageal Cancer
IMRT/Pemetrexed/Cisplatin in Esophageal Cancer
To evaluate the effect of concomitant late course accelerated hyperfractionation radiochemotherapy with pemetrexed and cisplatin in patients with esophagus cancer
- Trial name
- NCT01630174
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong Cancer Hospital and Institute
Sentinel Lymph Node Biopsy
Sentinel Node Detection in Cervical Cancer
Evaluation of sensitivity of Sentinel lymph nodes for detecting nodal metastases in cervical cancer
- Trial name
- SLNcxca (NCT03680833)
- Testing
- Sentinel node detection in cervical cancer
- Where
- Sweden
- Volunteers
- 226 people
- Sponsor
- Region Skane
Prostate Cancer
Neoadjuvant Hormones + Docetaxel in Node-Positive Prostate Cancer
The goal of this clinical research study is to find out if a therapy using docetaxel chemotherapy with hormonal therapy taken before your scheduled surgery is beneficial to treatment of prostate cancer.
- Trial name
- NCT01076335
- Testing
- Neoadjuvant Hormonal Therapy, Docetaxel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer
Preoperative Lymph Node Staging With EBUS-TBNA in Clinical N0 Non Small-cell Lung Cancer
The introduction of modern staging systems has increased the detection of small peripheral lung cancers at an early stage [1]. Stage I non-small-cell lung cancers (NSCLCs) are confined to the lung without lymph node involvement…
- Trial name
- NCT04828850
- Testing
- Endobronchial ultrasound transbronchial needle aspiration lymph node staging
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Unilateral Breast Neoplasms
Arm Swelling Occurence in Breast Cancer Patients With Nodal Radiotherapy: Impact of Informing Them of AI-predicted Risk
Radiotherapy after breast cancer surgery can lead to side effects like arm lymphedema (arm swelling). Lymphedema can cause long-term discomfort and affect quality of life.
- Trial name
- PRE-ACT-01 (NCT07187726)
- Testing
- XAINET AI tool
- Where
- 27 sites in France, Netherlands
- Volunteers
- 724 people
- Sponsor
- UNICANCER
Breast Cancer
Chemotherapy Omission in ER+/HER2- Breast Cancer With 1-3 Positive Lymph Nodes Receiving Extended Adjuvant Abemaciclib
This is a prospective, randomized, open-label, multicenter phase III study to explore chemotherapy omission in ER+/HER2-endocrine-sensitive breast cancer with 1-3 positive lymph nodes receiving extended (3 year) adjuvant…
- Trial name
- Rainbow (NCT06341621)
- Testing
- 3-year abemaciclib without chemo, treatment of physician's choice
- Where
- China
- Volunteers
- 1,900 people
- Sponsor
- Fudan University
Thyroid Cancer
A New Surgical Strategy to Protect the Inferior Parathyroid
The incidence of temporary hypoparathyroidism after thyroid surgery is 14%-60%, and the incidence of permanent hypoparathyroidism is 4%-11%.
- Trial name
- NCT05758025
- Testing
- Resection based on "thymus-vascular-inferior parathyroid" complex
- Where
- China
- Volunteers
- 506 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Squamous Cell Carcinoma Mouth
Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma
To evaluate the diagnostic accuracy of preoperative MRI in the determination of the primary tumor depth of invasion (DOI) as a predictor factor in neck lymph nodes management in T1T2N0 oral cavity squamous cell carcinomas as…
- Trial name
- NCT07127614
- Testing
- MRI, Histo-Pathological examination of the resected tumor tissues
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Al-Azhar University
Ductal Carcinoma In Situ
Comparative Effectiveness of Sentinel Lymph Node Biopsy for Ductal Carcinoma In Situ
Patients with ductal carcinoma in situ (DCIS) treated with available therapies have experienced excellent outcomes and very low mortality rates due to the disease's non-invasive nature.
- Trial name
- NCT02908178
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- United States
- Volunteers
- 28,291 people
- Sponsor
- Yale University
Biliary Tract Cancer
A Phase II Trial of Preoperative Chemotherapy for Biliary Tract Cancer (BTC) With Node Metastasis
To evaluate the efficacy and the safety of preoperative chemotherapy with Gemcitabine/ Cisplatin /S-1 for biliary tract cancers with lymph node metastasis by FDG-PET.
- Trial name
- NCT01821248
- Testing
- Gemcitabine, Cisplatin, S-1
- Where
- Japan
- Volunteers
- 25 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Breast Cancer
Lymph Node Removal in Treating Women Who Have Stage I or Stage IIA Breast Cancer
RATIONALE: Surgery to remove lymph nodes in the armpit may remove cancer cells that have spread from tumors in the breast. PURPOSE: Randomized phase III trial to determine the effectiveness of removing lymph nodes in the armpit…
- Trial name
- NCT00003855
- Testing
- axillary lymph node dissection, whole breast irradiation
- Where
- 156 sites in United States, Australia and 2 more
- Volunteers
- 605 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer, Lymph Node
Immune Function of Colorectal Cancer Lymph Nodes
Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity.
- Trial name
- NCT06319404
- Volunteers
- 500 people
- Sponsor
- Shanxi Province Cancer Hospital
Nasopharyngeal Cancinoma (NPC), Lymph Node Metastasis
A Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma(NPC)
(I) AI Model for Diagnosing Lymph Node Metastasis We developed an AI model to help diagnose whether a single lymph node in nasopharyngeal cancer has spread. The model uses MRI images of the lymph node and the area around it.
- Trial name
- NPC (NCT06829147)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-sen University
Prostate Cancer (Diagnosis), Prostate Cancer Stage IV
High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)
In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Stage IV, CV Risk
- Trial name
- NCT07223385
- Testing
- Cardio-Oncology Referral, Notification to PCP/General Cardiologist
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cedars-Sinai Medical Center
Endometrial Cancer, Sentinel Lymph Node
Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer
The investigators think that trans-cervical endometrial tracer injection will cause more paraaortic sentinel lymph node detection. Also, this application is easy, cost-effective and safer than hysteroscopic method.
- Trial name
- NCT03900104
- Testing
- Transcervical endometrial injection of technetium 99 m-labeled human albumin colloid particles, Cervical injection of technetium 99 m-labeled human albumin colloid particles
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Kocaeli University
Lung Cancer
Relation Between Tumor-draining Lymph Nodes Metastasis Pattern and Non-small Cell Lung Cancer Neoadjuvant Immunotherapy Effectiveness
The goal of this retrospective cohort analysis is to discover the impact of the involvement extent of tumor-draining lymph nodes (TDLNs) in patients who received neoadjuvant immunochemotherapy.
- Trial name
- NCT06292052
- Testing
- Immunotherapy
- Where
- China
- Volunteers
- 209 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Lymph Node Metastasis
Study on the No.253 Lymph Node Metastasis Patterns in Left-Sided Colon and Rectal Cancer
The goal of this observational study is to learn about the the pattern of metastasis of the No.253 lymph node in colorectal cancer. The main questions it aims to answer are: 1.
- Trial name
- NCT06135571
- Testing
- Laparoscopic colorectal surgery
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Endometrial Cancer
Pelvic Sentinel Node Detection Using Indocyanine Green Learning Curve
According to ESGO-ESTRO-ESMO guidelines, pelvic Sentinel lymph node detection is suitable for lymph node staging in endometrial carcinoma of the uteri.
- Trial name
- ENDO-GREEN (NCT04958278)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Lung Cancer
Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer
This research study is studying a new imaging method that will show lymph nodes in the lung during lung cancer surgery. The name of the study intervention involved in this study is: -- The combination of the FluoSCOPE device and…
- Trial name
- NCT02423148
- Testing
- Indocyanine green (ICG), FluoSCOPE
- Sponsor
- Dana-Farber Cancer Institute
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