Clinical trials: Lymphatic Function
Sarcoidosis, Sarcoidosis, Pulmonary
The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
This project focuses on the sub-group population with pulmonary sarcoidosis - a condition that causes red swollen tissue called granulomas to develop in organs such as the lungs.
- Conditions
- Sarcoidosis, Sarcoidosis, Pulmonary, ILD, Interstitial Lung Disease
- Trial name
- NCT03336736
- Testing
- Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kingston University
Lymphatic Insufficiency, Heart Failure
Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
- Conditions
- Lymphatic Insufficiency, Heart Failure, Edema
- Trial name
- LYMTRIVA (NCT04595448)
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Asthma; Eosinophilic
Homeostatic Roles of Eosinophils in Asthma
The HOMEOS study is an exploratory, observational, and monocentric research. It focuses on characterizing the homeostatic roles of eosinophils in severe asthma.
- Trial name
- HOMEOS (NCT06676397)
- Testing
- Blood Punction
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Child Development, Under Nutrition
Impact of Graduation on Child Development in Uganda - Wave 2 (Ancillary/Extension)
This ancillary/extension study ("Wave 2") measures child development and school readiness outcomes among children residing in households within host communities that participated in the Graduation to Resilience (G2R) randomized…
- Conditions
- Child Development, Under Nutrition, School Readiness, Anemia
- Trial name
- NCT07212374
- Testing
- Graduation
- Where
- Uganda
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Innovations for Poverty Action
Renal Impairment, Normal Renal Function
PK Study in Subjects With Renal Impairment (Severe and if Required Mild & Moderate) Compared to Subjects With Normal Renal Function
This is an open-label, non randomised, single-dose, study in male and female subjects with renal impairment (severe and if required mild \& moderate) compared to male and female subjects with normal renal function.
- Trial name
- NCT04656795
- Testing
- MT-7117
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Leukemia, Myeloid, Chronic-Phase
Imatinib Response in Patients With Chronic Myeloid Leukemia (CML) in Function of Abl Polymorphisms
The main objective of this study is to evaluate the existence of a relationship between the presence of certain abl polymorphisms (or haplotypes) upon CML diagnosis and the occurrence of primary resistance to the treatment of CML…
- Trial name
- abl LMC (NCT01650467)
- Where
- 3 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy, Autonomic Nervous System Diseases
Prevalence of Chapman Reflex Points in Medical Students and Their Association With Visceral Symptoms
Chapman Reflex Points (CRPs) are small palpable nodules found within connective tissue that have traditionally been associated with dysfunction of internal organs and the autonomic nervous system.
- Conditions
- Healthy, Autonomic Nervous System Diseases, Lymphatic Diseases, Somatic Dysfunction
- Trial name
- NCT07691112
- Testing
- Chapman Reflex Point Examination
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Breast Cancer, Lymphoma
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy
Cognitive impairments in cancer patients represent an important clinical problem. Studies to date estimating prevalence of difficulties in memory, executive function, and attention deficits have been limited by small sample sizes…
- Trial name
- CANTAB (NCT01382082)
- Where
- 29 sites in United States
- Volunteers
- 1,432 people, healthy volunteers welcome
- Sponsor
- University of Rochester NCORP Research Base
Renal Impairment
Safinamide Renal Impairment Trial
The primary purpose of the trial is to investigate the pharmacokinetics (behaviour of the compound in the body) of safinamide in subjects with different degrees of renal impairment in comparison to matched subjects with normal…
- Trial name
- NCT01374113
- Testing
- 50mg safinamide
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Newron Pharmaceuticals SPA
Eosinophilic Esophagitis (EoE)
Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation
Eosinophilic esophagitis (EoE) is an allergic inflammation of the esophagus. If not treated properly, inflammation and narrowing of the esophagus can occur. This can eventually lead to food impaction.
- Trial name
- SINFONIA (NCT07012928)
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Primary Myelofibrosis
Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells
The aim of this study is to demonstrate that, in patients with myelofibrosis (PMF), a chronic neoplastic disease of the bone marrow, some of the cells that form the bone marrow microenvironment (mesenchymal stromal cells, MSCs)…
- Trial name
- NCT06896344
- Testing
- In vitro culture
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Renal Impairment
A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment
The objective of this study is to assess and compare the pharmacokinetic properties of YM178 in normal subjects and those with mild, moderate and severe renal impairment.
- Trial name
- NCT00750620
- Testing
- YM178
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Atherosclerosis
Arterial Function and Atherosclerosis in Essential Thrombocythemia
The aim of the study is to examine (a) whether patients with JAK2 V617F positive ET in comparison to age-and sex-matched, apparently healthy control subjects show more advanced progression of arterial stiffness, pulse-wave…
- Trial name
- NCT03828422
- Testing
- imaging
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Gastroesophageal Reflux Disease (GERD), Eosinophilic Esophagitis (EoE)
Mucosal Impedance in Pediatric Population
Our hypothesis is that patients with GERD and/or Eosinophilic Esophagitis (EE) have lower esophageal impedance measurements when compared to patients who do not have GERD or EE.
- Conditions
- Gastroesophageal Reflux Disease (GERD), Eosinophilic Esophagitis (EoE), Functional Dyspepsia
- Trial name
- NCT02320981
- Testing
- Standard of Care esophagogastroduodenoscopy (EGD) with measurement of mucosal impedance
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Undernutrition, Anemia
Effect of Moringa Royal Jelly on the Nutritional Status and Cognitive Level of Adolescent Girls
The goal of this clinical trial is to learn whether a locally developed supplement called MRJ - a combination of Moringa oleifera (drumstick tree) extract and royal jelly - can improve the nutritional status and cognitive…
- Conditions
- Undernutrition, Anemia, Stunting, Cognitive Function 1, Social
- Trial name
- MRJ (NCT07037498)
- Testing
- Moringa Oleifera
- Where
- Indonesia
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Lymphatic System
Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway
Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a…
- Trial name
- NCT05253352
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Mild and Moderate Hepatic Impairment
Study to Assess Pharmacokinetics, Safety, and Tolerability of MT-7117 in Subjects With Normal and Impaired Hepatic Function
An Open-label, Single-center, Parallel-group Study to Assess Pharmacokinetics, Safety, and Tolerability of a Single Dose of MT-7117 in Subjects with Normal and Impaired Hepatic Function
- Trial name
- NCT04116476
- Testing
- MT-7117
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Wiskott-Aldrich Syndrome, Thrombocytopenia
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
The purpose of this project is to describe the pathophysiology of thrombocytopenia and bleeding in patients with Wiskott-Aldrich Syndrome (WAS) and determine the response to thrombopoietic agents in vitro and in vivo.
- Conditions
- Wiskott-Aldrich Syndrome, Thrombocytopenia, Bleeding
- Trial name
- WAS (NCT00909363)
- Testing
- Promacta, blood drawing in patients with WAS, blood drawing in healthy controls
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sickle Cell Anemia
Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease
Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue due to their disease. The investigators are interested in how blood flow and cerebral inflammation are different in SCA patients and how…
- Trial name
- NCT02445144
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine