Clinical trials: Lymphocytes
HIV Infections
Safety of and Immune Response to a New HIV Vaccine: HIV CTL MEP
The effectiveness of a vaccine can be improved by using a "prime boost strategy" or by using an adjuvant. A prime boost strategy is the administration of one type of vaccine (the primer) followed by the administration of another…
- Trial name
- NCT00076037
- Testing
- HIV CTL MEP administered with RC529-SE adjuvant, GM-CSF
- Where
- 7 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ovarian Cancer, Borderline Ovarian Tumors
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA.
- Conditions
- Ovarian Cancer, Borderline Ovarian Tumors, Benign Ovarian Tumor, Unexplained Infertility
- Trial name
- NCT03779399
- Testing
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Complement Abnormality, Peripheral Blood Mononuclear Cells
The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study
The current study is an open, non-randomized, monocentric, and interventional study. CoViD-19 patients will be recruited at UZ Brussel after informed consent is obtained.
- Conditions
- Complement Abnormality, Peripheral Blood Mononuclear Cells, Covid19
- Trial name
- TONIC (NCT05258643)
- Testing
- Blood analysis
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Healthy Volunteers
Development of a Cell Culture Process for the Production of Human T-lymphocyte Precursors
The purpose of this study is to finalise the development of a process for the production of T-cell progenitor cells.
- Trial name
- SMART101-HV1 (NCT05118113)
- Testing
- Collection of mobilized hematopoietic stem cells (apheresis products) from healthy volunteers
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Smart Immune SAS
Acute on Top of Chronic Liver Cell Failure
Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure
Acute on chronic liver failure (ACLF) is a clinical syndrome of sudden hepatic decompensation observed in patients with pre-existing chronic liver disease and associated with one or more extrahepatic organ failures and increased…
- Trial name
- ACLF (NCT06857682)
- Where
- Egypt
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arthritis, Juvenile Rheumatoid
Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Juvenile Idiopathic Arthritis
Background: The safety of vaccination in patients with autoimmune diseases using immune suppressive therapy is often discussed. Previous studies in Juvenile Idiopathic Arthritis (JIA) patients showed no increase in disease…
- Trial name
- VAART (NCT00731965)
- Testing
- Measles, Mumps, Rubella vaccination
- Where
- 5 sites in Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- N.M. Wulffraat
Healthy
Collection and Generation of Antigen-specific T-lymphocyte Cell Lines From Primary, Third-party, Related, and Unrelated Donors
The purpose of this study is to obtain lymphocyte collections from normal healthy volunteer donors in order to create Good Manufacturing Practice grade banks of virus-specific and tumor-reactive T-cells of defined HLA type and…
- Trial name
- NCT03114566
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Horton Disease
Study of T Lymphocytes in Patients With Horton Disease
Giant-cell arteritis (GCA) is the most frequent vasculitis after 50 years. Corticosteroid therapy is the reference treatment for GCA.
- Trial name
- GAMAIT (NCT03313102)
- Testing
- blood samples
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Melasma
Inflammation in Melasma: Study of Its Infiltrate and the Expression of Acute and Chronic Mediators
Melasma is an acquired hyperpigmentary disorder that commonly affects women from Asia and Latin-America.There is evidence of subclinical inflammation supported by diffuse spectrometry and by prominent inflammatory cells in…
- Trial name
- NCT01952379
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
HIV Seropositivity
Interaction Between HIV and Platelets
The investigators propose that the lack of immune response in InR is driven by HIV-containing platelets that might interact with macrophages and CD4+ T-cells although by different mechanisms.
- Trial name
- PLAQUEVIH (NCT04062825)
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis
Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation and joint destruction that follows a relapsing- remitting course.Disease activity assessment is important for rheumatoid arthritis management…
- Trial name
- NCT03617250
- Testing
- Disease Activity Score-28
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
HIV Infections, Healthy
Prediction and Testing of Antigenic Sites of the AIDS Virus, HTLV-III Recognized by T Lymphocytes for the Development of Synthetic Vaccines
Subjects are healthy adult volunteers either at high risk for HIV infection or already known to be seropositive, who will donate blood for in vitro tests of T-cell function and in vitro responses to synthetic peptides…
- Trial name
- NCT00001210
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
HIV-1 Infection
Gut-Associated Lymphocyte Trafficking
The gut immune barrier is not fully restored in HIV-1-infected subjects despite they were receiving antiretroviral treatment. This leaky gut leads to microbial translocation from the gut lumen into the bloodstream that fuels…
- Trial name
- GALT (NCT02906137)
- Testing
- Peripheral blood and intestinal biopsies will be collected
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Inflammation, Neutrophil
SIII and Spontaneous Regression in Lumbar Disc Herniation
This study aimed to investigate the role of the Systemic Immune-Inflammatory Index (SIII) in patients with lumbar disc herniation (LDH) and to evaluate its potential clinical relevance in relation to treatment modality.
- Conditions
- Inflammation, Neutrophil, Lymphocyte, Neurosurgery
- Trial name
- SIII-LDH (NCT07367503)
- Testing
- Lumbar disc herniation treatment, Lumbar disc herniation surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
HIV Infections
Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
The P-glycoprotein (P-gp) is a membranous transporter that modulates the intracellular concentrations of many drugs and plays thus a major role in the efficacy of the therapeutics that act within the lymphocytes, such as…
- Trial name
- Onto-Pgp (NCT00702013)
- Where
- France
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heat Intolerance, Genotypic Variations
Heat Intolerance- A Lesson From Global Genomic Response in Lymphocytes
Heat Intolerance (HI) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups.
- Conditions
- Heat Intolerance, Genotypic Variations, Gene Expression, Genomic Markers for Predisposition of Heat Intolerance
- Trial name
- NCT00918359
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Neonatal Hyperbilirubinemia, Phototherapy Complication
Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia
The aim of this study is to investigate the influence of the use of different types of phototherapy on different lymphocytes subsets CD4 and CD8 in the treatment of hyperbilirubinemia in neonates.
- Trial name
- NCT04373980
- Testing
- phototherapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rania Ali El-Farrash
Lymphocyte Subsets in Women of Child-bearing Age
Study About Lymphocytes Change During Menstrual Cycle in Women of Child-bearing Age
The investigators are going to select the normal child-bearing period women as the study subjects and draw their peripheral blood to observe and analyze the change of quantity and percentage of lymphocyte subsets along with the…
- Trial name
- NCT02951832
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital
Schizophrenia
A Neurobiological Study on Heterogeneity of Schizophrenia: Genetic Variations and Neurobiological Differentiations
Schizophrenia (SCH) is a devastating brain disorder with grave personal, family and social cost. SCH is a complex and heterogeneous (both genetic and clinical) disorder with oligogenetic endowed vulnerability risk of disease…
- Trial name
- SONPOS (NCT01075373)
- Where
- Taiwan
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Thyroid Cancer, Thyroid Nodule
Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Thyroid Malignancy
Thyroid surgery is the most common surgical procedure among endocrine surgeries. It is performed in patients with suspected malignancy, patients diagnosed with malignancy, and for toxic nodular goiter [1].
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Diseases, Delta Neutrophyl Index
- Trial name
- NCT04425512
- Testing
- Complete Blood Count
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University