Clinical trials: Lymphocytes
HIV Infections
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
To evaluate the degree and sequence of immunologic enhancement and the cellular resistance to certain infections after a single dose of atvogen (ampligen).
- Trial name
- NCT00001000
- Testing
- Ampligen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Edematous, Synovitis
Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements
This research study is being conducted to determine if taking oral (by mouth in pill form) Apatone®B (a combination of Vitamins C and K3) will reduce chronic joint discomfort and improve function of non-infected symptomatic…
- Conditions
- Edematous, Synovitis, Foreign Body Reaction, Osteolysis
- Trial name
- Apatone-B (NCT01272830)
- Testing
- Apatone®B
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- IC-MedTech Corporation
Recurrence, Metastasis
The Clinical Relevance of Immune Cells and CTC in HNSCC Patients
Head and neck squamous cell carcinomas (HNSCCs) are mainly caused by tobacco, alcohol consumption and betel nut chewing and the sixth most common cancer in the world.
- Conditions
- Recurrence, Metastasis, Death
- Trial name
- NCT02420600
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Kidney Transplant Infection, BK Virus Infection
BK With VST for Kidney Transplant Patients
This study measures the safety, feasibility, and efficacy of viral-specific T cells (VST) against BK Virus (BKV) in adult kidney transplant recipients. Participants are expected to be on study for 52 weeks.
- Trial name
- NCT05042076
- Testing
- BK-specific T cells from Donor Lymphocytes
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Ductal Adenocarcinoma (PDAC), Colorectal Cancer (CRC)
Advanced Therapies for Liver Metastases
Liver metastases (MTS) are the main cause of death for patients affected by colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC), thus representing the major unmet clinical need for these malignancies.
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Colorectal Cancer (CRC), Liver Metastasis, IPMN, Pancreatic
- Trial name
- LiMeT (NCT04622423)
- Where
- Italy
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Allogeneic Stem Cell Transplantation
HHV-6-specific T-cell Reconstitution Among Children and Adolescents After Allogeneic Stem.
Human herpesvirus 6 (HHV-6) causes only minor symptoms in healthy individuals but in immunosuppressed patients, e.g., patients after allogeneic stem cell transplantation (HSCT), HHV-6 reactivations can lead to diseases in…
- Trial name
- CIRAST HHV-6 (NCT06256341)
- Testing
- Cell cultivation, Antigen testing
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Lymphocytic Enteritis (Disorder), Healthy Volunteers
Evaluation of the Lymphocyte Subpopulations in the Normal Mucosa of the Upper Digestive Tract
The macro and microscopic findings of the upper gastrointestinal tract are useful in the differential diagnosis of digestive diseases such as Crohn's or celiac diseases.
- Trial name
- GUTproject (NCT05084807)
- Testing
- Endoscopy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Relapsing Remitting Multiple Sclerosis
Mechanistic Studies of Teriflunomide in RRMS
This study is to address the mechanism of action of teriflunomide in a phase IV open label trial with Teriflunomide in multiple sclerosis.
- Trial name
- NCT03464448
- Testing
- Teriflunomide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Trauma Injury, Coagulopathy
Predictive Accuracy of PLR and PNR in Detecting ETIC
Observational study to know what is the predictive accuracy of platelet-neutrophil ratio (PNR) and platelet-lymphocyte ratio (PLR) done in patients presenting to ED( emergency department)within 6 hours of trauma; in detecting…
- Trial name
- ETIC (NCT07046858)
- Where
- India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
Glaucoma, Healthy Subjects
mRNA Expression in Lymphocytes of Glaucoma Patients
The aim of the study is to compare messenger ribonucleic acid (mRNA) expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects.
- Trial name
- NCT00327509
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Bipolar Affective Disorders
Chemokine Receptors on CD8+ T Cells in Patients With Bipolar Disorder
This observational study investigates the expression profile of chemokine receptors and adhesion molecules in CD8+ T lymphocytes from individuals with Bipolar Disorder compared with healthy controls.
- Trial name
- SPERLIC (NCT07785167)
- Testing
- CD8+ T-Cell Gene Expression Analysis
- Where
- Italy
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Catania
Complication of Transplant
Combined Infusion of Cytotoxic T-Lymphocytes and Vaccination
To assess the safety and biological efficacy of prophylactically administered donor-derived multi-infection specific cytotoxic T lymphocytes (CTLs) (targeting cytomegalovirus (CMV), Adenovirus (Adv), Epstein Barr virus (EBV)…
- Trial name
- CYNTAX (NCT02843321)
- Testing
- T-cell infusion, influenza vaccination
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Graft-Versus-Host Disease, Graft-versus-leukemia
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives
Bone marrow transplants (BMT) are one form of treatment for disorders of the blood, including leukemia. However, because the procedure is often associated with potentially life-threatening reactions, it is usually reserved for…
- Conditions
- Graft-Versus-Host Disease, Graft-versus-leukemia, Donor Apheresis
- Trial name
- NCT00001529
- Testing
- G-CSF
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HIV, Healthy Volunteers
Use of Labeled Glucose to Study Lymphocyte Replication and Survival in HIV-Infected Patients
This study will examine how quickly white blood cells called CD4 lymphocytes replicate (divide) and how long they live in both HIV-infected and non-infected people by measuring how quickly the genetic material (DNA) of cells is…
- Trial name
- NCT00001651
- Testing
- [6,6-2H2]-glucose
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Systemic Lupus Erythematosus With or Without Clinical Activity
Anti-nucleosome B Lymphocytes in Lupus
Lupus disease is characterized by the production of pathogenic autoantibodies, which participate in end-organ damages. The phenotype of B cells producing the pathogenic autoantibodies in lupus patients is today unknown.
- Trial name
- NCT01889654
- Testing
- Venous blood sampling
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Juvenile Idiopathic Arthritis
Analysis of Peripheral Blood Lymphocytes in Patients With Juvenile Idiopathic Arthritis With Respect to Disease Subtypes and Therapy
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. JIA is an umbrella term defining several forms of chronic arthritis with an onset before the age of 16 years, persisting for more than…
- Trial name
- NCT06413563
- Testing
- Complete blood count
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chronic Myeloid Leukemia, Healthy
The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic Malignancies
Allogeneic bone marrow transplantation (BMT) is a curative treatment for patients with chronic myelogenous leukemia (CML) and other lymphoid/hematologic malignancies but is available as a treatment option to only a minority of…
- Conditions
- Chronic Myeloid Leukemia, Healthy, Hematologic Neoplasm, Lymphoma
- Trial name
- NCT00001432
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)