Clinical trials: MARS
Asthma
Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)
The MARS trial is a randomized, double-blind, parallel group study that compares the capacity of azithromycin or montelukast to placebo as effective adjunctive therapy that allows reduction of inhaled corticosteroids in children…
- Trial name
- MARS (NCT00471809)
- Testing
- Budesonide + Salmeterol + Azithromycin, Budesonide + Salmeterol + Montelukast
- Where
- 6 sites in United States
- Volunteers
- 210 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bile Duct Obstruction, Extrahepatic
Clinical Validation of an Immunocytochemistry Method Using MARS1
The sensitivity of brushing cytology used to distinguish the cause of biliary strictures is low and clinical usefulness is not secured.
- Trial name
- MARS1 (NCT04759794)
- Testing
- Cytology staining
- Where
- 5 sites in South Korea
- Volunteers
- 55 people
- Sponsor
- Gangnam Severance Hospital
Liver Failure
Elimination of Albumin-Bound Substances by MARS and Prometheus
This trial compares the efficacy of two artificial liver support systems, MARS (Molecular Adsorbents Recirculating System) and Prometheus (FPSA, Fractionated Plasma Separation and Adsorption), in removing albumin-bound substances…
- Trial name
- NCT00407004
- Testing
- MARS (Molecular Adsorbents Recirculating System), Prometheus (FPSA, Fractionated Plasma Separation and Adsorption)
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
PTSD
Mobile Acoustic Startle Reflex-monitoring System (MARS)
This is a pilot study of 55 adult male veterans with PTSD. The study will test a new mobile application "app" that can be run on an iPhone10.
- Trial name
- NCT04113850
- Testing
- Mobile Acoustic startle Reflex monitoring System (MARS)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Johns Hopkins University
Arthroplasty, Replacement, Hip
MARS MRI in Revision THA With a Ceramic Femoral Head and Titanium Sleeve
Revision total hip replacement using a ceramic head utilizes a titanium sleeve which introduced another articulation into the system that may lead to a local soft tissue reaction.
- Trial name
- NCT05686915
- Testing
- MARS MRI, Titanium Labs, Cobalt Labs
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Colorado Joint Replacement
Interstitial Lung and Liver Disease, Infantile Liver Failure Syndrome 1
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress
Mutations in the genes encoding cytosolic aminoacyl-tRNA synthetases are responsible for early-onset multisystemic diseases including to varying degrees interstitial lung disease, liver damage, neurological and digestive…
- Conditions
- Interstitial Lung and Liver Disease, Infantile Liver Failure Syndrome 1, Neurologic, Endocrine and Pancreatic Disease, Multisystem, Infantile-Onset 2, Rajab Interstitial Lung Disease With Brain Calcifications 2
- Trial name
- FIBROMARS (NCT05514470)
- Testing
- Skin biopsy
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Failure, Acute, Chronic Hepatic Failure
Comparison of Two Liver Dialysis Systems : MARS Versus SPAD in Severe Liver Failure
A critical issue of the clinical syndrome in liver failure is the accumulation of toxins not cleared by the failing liver. Based on this hypothesis, albumin dialysis is used to remove those substances.
- Trial name
- MARSPAD (NCT02310542)
- Testing
- MARS albumin dialysis system, SPAD albumin dialysis system
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon
Sleep Disorders in Children
Melatonin Adolescent Research Study
The present study will use a within-person, randomized cross-over experimental design to test the effects of exogenous melatonin supplementation on the sleep and daytime functioning of typically developing adolescents with short…
- Trial name
- MARS (NCT04588233)
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Loma Linda University
Liver Failure
Citrate Anticoagulation During MARS Treatment
The optimal anticoagulation procedure during MARS treatment has not been defined. In various multi-centre trials, such as MARS-RELIEF, anticoagulation procedures are left to the discretion of the treating physician.
- Trial name
- NCT00695617
- Testing
- trisodiumcitrate
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia
This study is a multi-center, randomized, active-controlled, double-blind, non-inferiority, phase III clinical trial evaluating efficacy and safety of once-daily mosapride (UI05MSP015CT) in patients with functional dyspepsia.
- Trial name
- NCT03225248
- Testing
- UI05MSP015CT, Gasmotin
- Volunteers
- 143 people
- Sponsor
- Korea United Pharm. Inc.
Pancreatitis, Multiple Organ Failure
Albumindialysis in Acute Pancreatitis
The incidence of acute pancreatitis has been doubled during last three decades in Finland. Alcohol is the main cause of acute pancreatitis in Finland accounting for 70 % of cases.
- Trial name
- pancreatitis (NCT00483912)
- Testing
- Molecular adsorbent recirculating system
- Where
- Finland
- Sponsor
- Tampere University
Alcoholic Hepatitis, Acute Liver Failure
Outcomes Using MARS for Patients With ALF
Retrospective chart review will be conducted on patients at Methodist Dallas Medical Center, meeting the inclusion criteria from January 1, 2019 to December 15, 2020 to determine the transplant free survival and overall survival…
- Trial name
- NCT05594953
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Methodist Health System
Pancreatic Cancer
Development of a New Immunochemistry Method Using Antibodies of Proteins Related Pancreatic Cancer
Identifying the malignancy of pancreatic mass using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is important for treatment decision-making and prognosis prediction.
- Trial name
- NCT04293497
- Testing
- Cytology staining
- Where
- 4 sites in South Korea
- Volunteers
- 97 people
- Sponsor
- Gangnam Severance Hospital
Primary Hypercholesterolaemia and Mixed Dyslipidaemia, Atherosclerotic Cardiovascular Disease
Non-interventional Study on the Monthly Administration of 300 mg AliRocumab (PRALUENT®) With the 2 ml SYDNEY Auto-injector
Primary objectives: To assess the effectiveness of the PRALUENT® 2 ml SYDNEY auto-injector as measured by the lipid-lowering effect of alirocumab after approx.
- Trial name
- MARS (NCT05129241)
- Where
- Germany
- Volunteers
- 163 people
- Sponsor
- Sanofi
Cardiac Surgery, Surgery
Management of Antiplatelet Regimen During Surgical Procedures
There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS.
- Conditions
- Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications
- Trial name
- MARS (NCT03981835)
- Where
- 5 sites in United States
- Volunteers
- 147 people
- Sponsor
- Baylor Research Institute
Current Smoker, Tobacco Smoking
Project MARS: Mobile-Assistance for Regulating Smoking
This study aims to investigate approaches to capitalize on states of vulnerability and receptivity to deliver real-time self-regulation prompts among smokers.
- Trial name
- MARS (NCT04376489)
- Testing
- Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants not experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are not available)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Utah
Liver Failure
Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal Failure
The objective of this trial is to evaluate the impact of elimination of albumin bound substances during albumin dialysis (MARS®) on mortality and the clinical time course in patients with a recent severe clinical deterioration of…
- Trial name
- RELIEF (NCT00614146)
- Testing
- MARS device, Standard medical therapy
- Where
- 19 sites in Austria, Belgium and 7 more
- Volunteers
- 59 people
- Sponsor
- Vantive Health LLC
Parkinson Disease
Meridian Activation Remedy System for Parkinson's Disease
In this study, the investigators aim to evaluate the clinical efficacy and cost-effectiveness of MARS-PD. Conventional, usual care will be used as the comparator because this trial aims to assess the add-on effect of MARS-PD.
- Trial name
- MARS-PD (NCT05621772)
- Testing
- Meridian Activation Remedy System for Parkinson's Disease (MARS-PD)
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Korea Health Industry Development Institute
Mucopolysaccharidosis IV Type A, Morquio A Syndrome
A Multicenter, Multinational, Observational Morquio A Registry Study (MARS)
The objectives of this program are: to characterize and describe the Mucopolysaccharidosis IV type A (MPS IVA) population as a whole, including the heterogeneity, progression, and natural history of MPS IVA; to evaluate the…
- Conditions
- Mucopolysaccharidosis IV Type A, Morquio A Syndrome, MPS IVA
- Trial name
- MARS (NCT02294877)
- Testing
- Vimizim® (elosulfase alfa)
- Where
- 79 sites in United States, Australia and 15 more
- Volunteers
- 418 people
- Sponsor
- BioMarin Pharmaceutical
Pregnancy
Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy
The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to…
- Trial name
- NCT06314009
- Testing
- functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health