Clinical trials: MARS
Hepatic Encephalopathy, Liver Failure
Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS)
The primary objective of the study was to compare the efficacy, safety and tolerability of Extracorporeal Albumin Dialysis (ECAD) using the Molecular Adsorbent Recirculating System (MARS®) device in improving severe HE by 2…
- Conditions
- Hepatic Encephalopathy, Liver Failure, Hepatitis, Chronic, Liver Cirrhosis
- Trial name
- NCT00287235
- Testing
- MARS, Standard Medical Therapy
- Where
- 8 sites in United States, Belgium and 1 more
- Volunteers
- 70 people
- Sponsor
- Vantive Health LLC
Muscular Atrophy
Biological and Functional Markers for Precision Astronautical Biomedicine
In the current study the investigators will study early biomarkers of human degradation. In 10-day horizontal bed rest the investigators will enroll 10 healthy male subjects (18-30years, BMI 20-28kg/m2).
- Trial name
- MARS-PRE (NCT04081467)
- Testing
- Bed rest
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Obesity
Microvascular Flow Assessment Repeatability Study: The MARS Study
The purpose of this study is to test a method of imaging (taking a picture) of the abdomen (belly), neck, thigh and calf (lower leg) areas of the body, using ultrasound along with a drug which makes the pictures look clearer.
- Trial name
- MARS (NCT01242020)
- Testing
- Perflutren Lipid Microsphere Injectable Suspension
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency
Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)
The aims of this study are to investigate whether mannitol stimulates copeptin (part 1: proof-of-concept) and whether the copeptin levels upon mannitol infusion differ in primary polydipsia and arginine vasopressin deficiency…
- Conditions
- Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency, Primary Polydipsia
- Trial name
- MARS (NCT06542198)
- Testing
- Mannitol Infusion (blinded), Mannitol Infusion (open label)
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Mesothelioma
Mesothelioma and Radical Surgery 2
Mesothelioma is a cancer of the thin membrane that lines the chest and abdomen. Around 2500 people in the UK are diagnosed with mesothelioma each year and the median survival is approximately 8.5 months.
- Trial name
- MARS2 (NCT02040272)
- Testing
- (Extended) pleurectomy decortication
- Where
- 25 sites in United Kingdom
- Volunteers
- 328 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Stroke
Monitoring Arm Recovery After Stroke (MARS)
People who have a stroke often find it hard to do the things they did before. This can be caused by problems with arm movement. One in five people do not get any arm movement back after a stroke.
- Trial name
- MARS (NCT07016295)
- Testing
- Biomechanical analysis of arm movement, Pose estimation of arm movement
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Pulmonary Alveolar Proteinosis, Mutation Ala393Thr of the MARS Gene
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.
The purpose of this study is to determine the safety and tolerance of an oral administration of methionine in the treatment of pulmonary alveolar proteinosis due to the double mutation Ala393Thr / Ser567Leu in the MARS gene.
- Conditions
- Pulmonary Alveolar Proteinosis, Mutation Ala393Thr of the MARS Gene, mutationSer567Leu of the MARS Gene
- Trial name
- MetPAP (NCT03887169)
- Testing
- Methionine, Vitamin B12, B9, B6, C supplementation, Methionine/homocysteine Dosage
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Placenta Diseases
MARS: Magnetic Resonance Study: A Novel Assessment of Placental Function
The objective of this study is to evaluate functional MRI as a tool to study placental transfer of oxygen and nutrients during the third trimester of pregnancy in obese women, women with pregestational diabetes and healthy low…
- Trial name
- NCT03764878
- Testing
- functional MRI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Sleep, Alertness
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars
The success of human expedition missions critically depend on the ability of the crew to be alert and maintain high levels of cognitive function while operating complex, technical equipment.
- Conditions
- Sleep, Alertness, Fatigue
- Trial name
- Mars 105 (NCT01169233)
- Testing
- Bright Light Box
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Instructional Virtual Realities, Weightlessness Simulation
VR-MARS Virtual Reality, Medical Assistance and Rescue for Space
VRMARS is a medical simulation study in microgravity. Healthy volunteers (n=18) test in microgravity the functionnality of an augmented reality headset in which a medical assistance is displayed.
- Conditions
- Instructional Virtual Realities, Weightlessness Simulation, Space Simulation, Patient Simulation
- Trial name
- VR-MARS (NCT06144658)
- Testing
- Augmented Reality Headset / Hololens 2 or Varjo XR3
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de Bretagne Sud
Abdominopelvic Sarcomas
Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)
Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation…
- Trial name
- NCT06436612
- Testing
- Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Atherosclerosis, Coronary Artery Disease
MARS - Monitored Atherosclerosis Regression Study
The purpose of this study is to determine whether significant alterations in serum lipoproteins as provided by the drug lovastatin can substantially reduce atherosclerosis progression or even induce regression.
- Trial name
- NCT00116870
- Testing
- lovastatin
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Merck Sharp & Dohme LLC
Extraterrestrial Habitation Systems, Lunar Surface Habitation
A Multiphase Operational and Environmental Assessment of Lunar Surface Habitation, Lunar Gateway Transit Systems, and Acceleration Pathways for Sustained Human Habitation of the Martian Surface
This study evaluates the operational, environmental, and habitation-system requirements for sustained human presence on the lunar surface, the performance of the Lunar Gateway as a transit and staging architecture, and the…
- Conditions
- Extraterrestrial Habitation Systems, Lunar Surface Habitation, Lunar Water-Ice Resource Assessment, In-Situ Resource Utilization (ISRU)
- Trial name
- LUMEN-HAB (NCT07546461)
- Testing
- Habitat Systems Evaluation, Water-Ice Resource Utilization Assessment, EVA and Mobility Operations
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Prostate Cancer
MRI Assisted Focal Boost With HDR Monotherapy for Prostate Cancer Patients
Radiation therapy plays an important role in the management of prostate cancer. In recent years it has become evident that higher doses of radiation are required to optimize disease control.
- Trial name
- MARS (NCT02623933)
- Testing
- MRI assisted focal boost with HDR monotherapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Liver Failure as A Complication of Care
Early Liver Support With MARS in Post-hepatectomy Liver Failure
This is a prospective, randomized, open-label, multicentre study involving European centers with experience in the management of PHLF to assess the impact of early liver support with MARS on survival in patients with…
- Trial name
- ELISH (NCT03761238)
- Testing
- Molecular Adsorbent Recirculating System, Standard medical treatment (SMT)
- Volunteers
- 44 people
- Sponsor
- Stefan Gilg, MD, PhD
Kidney Scarring
Detection of Renal Fibrosis and Prediction of Kidney Function Decline
This study will investigate the ability of renal MRI to detect fibrosis, how this correlates to renal function and how well renal MRI biomarkers can predict decline in kidney function over time.
- Trial name
- MARS (NCT04625140)
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Traumatic Brain Injury, Cognitive Dysfunction
Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patients With Acute Traumatic Brain Injury
Currently, the treatment of cognitive dysfunction after acute TBI remains a challenge, and novel therapeutic methods are urgently needed.
- Trial name
- MARS-TBI (NCT07413562)
- Testing
- Median nerve stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Oxidative Stress
Monitoring Antioxidant/Redox Status at Concordia (MARS-C)
The European Space Agency (ESA) runs a research centre in Antarctica as an earth-based model for long duration deep-space missions.
- Trial name
- MARS-C (NCT04197193)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Hypoxic Hepatitis, Ischemic Hepatitis
Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis
Hypoxic hepatitis (HH) is reported to be the most frequent cause of elevated aminotransferase levels in hospital. Up to 10 % of critically ill patients develop HH during the course of their intensive care unit (ICU) stay.
- Conditions
- Hypoxic Hepatitis, Ischemic Hepatitis, Shock Liver, Hypoxic Liver Injury
- Trial name
- MARS in HH (NCT01690845)
- Testing
- MARS
- Where
- 2 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Acute Pain, Emergencies
Machine Learning for Risk Stratification in the Emergency Department (MARS-ED)
Rationale Identifying emergency department (ED) patients at high and low risk shortly after admission could help decision-making regarding patient care.
- Trial name
- MARS-ED (NCT05497830)
- Testing
- RISK-INDEX
- Where
- Netherlands
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center