Clinical trials: MDD
Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder
Effects of Early Abuse on Adult Intimate Relationships
This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood.
- Conditions
- Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, Female Orgasmic Disorder, Major Depressive Disorder
- Trial name
- NCT01803802
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Major Depression in Remission
Online Cognitive Control Training for Remitted Depressed Patients
This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
- Trial name
- NCT03278756
- Testing
- Cognitive control training, Active control training
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Ghent
Major Depressive Disorder
A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline
LY2216684 is being studied as adjunctive treatment for major depressive disorder (MDD) in participants who are partial responders to selective serotonin reuptake inhibitors (SSRIs).
- Trial name
- NCT01250873
- Testing
- LY2216684, Sertraline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bipolar Disorder, Major Depressive Disorder
The Gut Microbiota of Bipolar and Depression
Background: The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment.
- Trial name
- NCT03062332
- Testing
- Faecal genome
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Depression
Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Site
This study will evaluate the effectiveness of interpersonal psychotherapy in treating pregnant women with depression.
- Trial name
- NCT00251043
- Testing
- Interpersonal psychotherapy for depression in pregnancy, Parenting education program (PEP)
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Major Depression
Blood Biomarkers in Suicidal Behaviour
Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year.
- Trial name
- 2BSB (NCT02855918)
- Testing
- Blood sample for genetic purpose
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depression, Functional Dyspepsia
The Brain-Heart-Gut Connection
Major Depressive Disorder (MDD) often co-occurs with cardiovascular and gastrointestinal symptoms, highlighting the importance of the brain-heart-gut connection in developing comprehensive treatments.
- Conditions
- Major Depression, Functional Dyspepsia, Autonomous Dysfunction
- Trial name
- BHG-CONNECT (NCT06748274)
- Testing
- Transcranial Magnetic Stimulation (TMS), High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bern
Schizophrenia, Bipolar Disorder
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
The purpose of this study is to better understand mental illness and will test the hypotheses that, while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after…
- Conditions
- Schizophrenia, Bipolar Disorder, Healthy, Psychosis
- Trial name
- GABAmech (NCT04004416)
- Testing
- Lorazepam and fMRI
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depressive Disorder, Bipolar Disorder
Behavioral Processes Underlying Reward Processing in Depression
The purpose of this project is to use behavioral techniques to investigate emotional processing in subjects with major depression and healthy comparison subjects.
- Trial name
- NCT00205933
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Affective Neuroscience Laboratory
Major Depressive Disorder (MDD), Schizophrenia
Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental Disorders
This is an observational study aiming to screen biomarkers associated with the diagnosis and treatment outcomes of severe mental disorders (MDD/major depressive disorder, SZ/schizophrenia, BD/bipolar disorder) through 7T…
- Conditions
- Major Depressive Disorder (MDD), Schizophrenia, Bipolar Disorder, Severe Mental Disorders
- Trial name
- NCT07479758
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Major Depressive Disorder, Depression
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action.
- Trial name
- NCT05571878
- Testing
- Humalog, Saline nasal spray
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Recurrent, Depressive Episode
Confirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
The study examines whether people primarily want to confirm their prior attitudes in health-related information search, in an online environment using social tags for navigation.
- Conditions
- Major Depressive Disorder, Recurrent, Depressive Episode, Depressive Disorder, Major, Depression
- Trial name
- NCT03899168
- Testing
- Social Tag Popularity, Confidence in Prior Attitudes, Source Credibility
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Leibniz-Institut für Wissensmedien
Major Depressive Disorder, Dementia
Screening for Mental Health Concerns for at-Risk Community Living Chinese Seniors
The study is designed to answer the following research questions: 1. Evaluate the acceptability of mental health screening and of the instruments used in a sample of community living Chinese seniors; 2.
- Trial name
- NCT00433238
- Testing
- Participants will be screened for depression and cognitive impairment, then receive screening results.
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients
The purpose of this study is to explore the effect of an inflammatory and a psychosocial stressor and the combination thereof on mood in healthy young and elderly participants and patients with Major Depressive Disorder (MDD).
- Trial name
- NCT01533285
- Testing
- Salmonella typhi vaccine (Typhim Vi)
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Healthy
A Phase 1 Study To Investigate The Pharmacokinetics, Safety And Tolerability Of CP-601,927 In Healthy Japanese Subjects
This Phase 1 study is the first clinical trial to be conducted in Japanese subjects. The pharmacokinetics, safety and tolerability of single and multiple doses of CP-601,927 will be evaluated in Japanese, healthy, non-smoking…
- Trial name
- NCT01396135
- Testing
- CP-601,927
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Depressive Disorder, Major Depressive Disorder, Healthy Volunteer
Exploring the Role of the Prefrontal Cortex in Decision-Making
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
- Trial name
- NCT07080489
- Testing
- Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/F4, Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/ kathodal F4
- Where
- Switzerland
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- University of Bern