Clinical trials: ME/CFS
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Effect of Probiotics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease. Currently there is no effective treatment for ME/CFS due to unclear etiology of the disease.
- Trial name
- NCT04741841
- Testing
- GutMagnific™ H., GutMagnific™ L.
- Where
- Sweden
- Volunteers
- 74 people
- Sponsor
- ImmuneBiotech Medical Sweden AB
Encephalomyelitis, Chronic Fatigue Syndrome
A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS
The purpose of this research is to evaluate the use of a voice-based tool in the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
- Trial name
- NCT07551999
- Testing
- Voice Recording
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Munich ME/CFS Cohort Study
The Munich cohort study MUC-CFS aims at the characterization and long-term follow-up of myalgic encephalitis/chronic fatigue syndrome (ME/CFS) in young people aged up to 25 years, as well as at the identification of…
- Trial name
- MUC-CFS (NCT06005246)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Low-Dose Naltrexone For ME/CFS: Dose-Finding
This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.
- Trial name
- NCT07285473
- Testing
- Low-Dose Naltrexone, 1.5mg, Low-Dose Naltrexone, 3.0mg, Low-Dose Naltrexone, 4.5mg
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Alabama at Birmingham
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Long COVID Fatigue
Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID
The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID who also…
- Trial name
- NCT07745699
- Testing
- Ketogenic Metabolic Therapy, Lifestyle Intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National University of Natural Medicine
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), ME/CFS Following COVID-19
Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe, often infection-triggered disease characterized by debilitating fatigue and post-exertional malaise lasting over 14 hours, along with pain, cognitive…
- Trial name
- IMPACT (NCT07529197)
- Testing
- IA with TheraSorb ® column (Miltenyi)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME)
Physical Activity Monitoring in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
The investigators will assess the feasibility of activity monitoring armbands for continuous measurement of physical activity level in ME/CFS patients, during 6 months follow-up.
- Trial name
- NCT04195815
- Where
- Norway
- Volunteers
- 27 people
- Sponsor
- Haukeland University Hospital
Long COVID, Chronic Fatigue Syndrome
tVNS in Long COVID-19
A prior open label study has shown that transcutaneous vagus nerve stimulation [tVNS] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill…
- Trial name
- NCT06585254
- Testing
- Transcutaneous vagus nerve stimulator
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-COVID-19 Syndrome
Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome
This is a multicenter, randomized, placebo controlled, double-blind phase III trial with four parallel groups studying studying the feasibility of RCT in primary care as well as the effectiveness of treatment with prednisolone…
- Trial name
- PreVitaCOV (NCT05638633)
- Testing
- Prednisolone 20 mg/ 5 mg, Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12)
- Where
- 3 sites in Germany
- Volunteers
- 321 people
- Sponsor
- Wuerzburg University Hospital
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
multi-center, double-blind, randomized, placebo-controlled study of the safety and efficacy.
- Trial name
- NCT00215800
- Testing
- Ampligen
- Volunteers
- 234 people
- Sponsor
- AIM ImmunoTech Inc.
ME/CFS, CFS/ME
Multi-Center Registry for ME/CFS
The ME/CFS study (MECFS-R) aims to create a large-scale registry that provides data on epidemiology, phenotypes, and disease trajectories of and health care for ME/CFS at any age in Germany, which can be used for future clinical…
- Conditions
- ME/CFS, CFS/ME, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19
- Trial name
- MECFS-R (NCT05778006)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Technical University of Munich
Functional Disorders, Post Covid-19
AIR-program and HUS Internet Therapy Compared to Treatment as Usual in Functional Disorders and Post Covid-19 Condition
This study will compare an Amygdala and insula retraining (AIR) program to an internet therapy developed at Helsinki University Hospital. The study will be a multi-center randomized controlled trial.
- Trial name
- NCT05212467
- Testing
- AIR-program, HUS Internet therapy, Treatment as usual
- Where
- 2 sites in Finland
- Volunteers
- 360 people
- Sponsor
- Helsinki University Central Hospital
Chronic Fatigue Syndrome
Use of a Monitor in ME/CFS
The use of an activity monitor to determine increase or decrease of activity in patients suffering from chronic fatigue syndrome.
- Trial name
- NCT01908036
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York CFS Association
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
PEM, a Starting Point to Investigate ME/CFS
Exercise is an important contributor to general health and is considered a potential remedy for chronic diseases. This is in strong contrast with the observation that in most myalgic encephalomyelitis (ME/CFS) patients exercise…
- Trial name
- PEM_CFS (NCT07715838)
- Testing
- No intervention is planned
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
RESTORE ME -- RCT of Oxaloacetate on Improving Fatigue in ME/CFS
There is no approved treatment for fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a condition with as many as 2.5 million people in the US.
- Conditions
- Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Fatigue
- Trial name
- NCT05273372
- Testing
- Medical Food - Anhydrous Enol-Oxaloacetate
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Terra Biological LLC
Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME)
B-lymphocyte Depletion Using Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Randomized Phase-III Study.
The hypothesis is that a subgroup of patients with Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME) have a chronically activated immune system and may benefit from B-lymphocyte treatment using the monoclonal anti-CD20…
- Trial name
- RituxME (NCT02229942)
- Testing
- Rituximab
- Where
- 5 sites in Norway
- Volunteers
- 151 people
- Sponsor
- Haukeland University Hospital
Chronic Fatigue Syndrome
ME/CFS, Hypermobility and Craniocervical Obstructions
A retrospective study on clinical and radiological findings in ME/CFS
- Trial name
- NCT04399330
- Where
- Sweden
- Volunteers
- 225 people
- Sponsor
- Bragee Clinics