Clinical trials: ME/CFS
Chronic Fatigue Syndrome
Exploring Worry in CFS/ME
This study will be building on the findings of Kalfas et al 2022 paper exploring the prevalence of generalised worry in patients with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) before and after Cognitive…
- Trial name
- NCT06011135
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- King's College London
Chronic Fatigue Syndrome (CFS), Post-COVID ME/CFS
RCT of Efficacy and Safety of CP003 on CFS/ME or Post COVID-19 Fatigue
The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use.
- Trial name
- NCT06739720
- Testing
- LingZhi capsule
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- The University of Hong Kong
LONG-COVID, Post-acute Sequelae of COVID-19
Skeletal Muscle in PASC and ME/CFS Patients
Rationale: A common feature in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are skeletal muscle-related symptoms, such as muscle pain, weakness…
- Conditions
- LONG-COVID, Post-acute Sequelae of COVID-19, ME/CFS
- Trial name
- NCT05225688
- Testing
- Bike exertion test
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ME/CFS, IBS - Irritable Bowel Syndrome
The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel…
- Trial name
- NCT06211062
- Testing
- Floradapt Intensive GI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nova Southeastern University
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Post-COVID / Long-COVID, ME/CFS
Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS
This study is testing whether a gentle electrical stimulation of a nerve in the ear, called the vagus nerve, can help reduce fatigue and improve symptoms in people with Post-COVID Syndrome or Myalgic Encephalomyelitis/Chronic…
- Trial name
- STIMPACT (NCT06968104)
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Luxembourg
- Volunteers
- 48 people
- Sponsor
- University of Luxembourg
Post-COVID ME/CFS
Hyperbaric High Pressure Oxygen Therapy in Post-COVID Syndrome and ME/CFS
The objective of this observational study is to document symptom progression in 60 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) who undergo Hyperbaric Oxygen Therapy (HBOT) following COVID or other…
- Trial name
- NCT06118138
- Testing
- Hyperbaric oxygen therapy (HBOT)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Fatigue Syndrome, Burnout
A Longitudinal Study on Longstanding Complicated Fatigue
The purpose of the study is to investigate if there are common biopsychosocial vulnerability factors for developing and maintaining fatigue, regardless of the diagnosis.
- Conditions
- Chronic Fatigue Syndrome, Burnout, Covid19
- Trial name
- NCT04955587
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Placebo controlled trial study of efficacy of Kinetic Oscillation Stimulation (KOS) in nasal cavity will be conducted in patients with myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
- Trial name
- NCT03502044
- Testing
- Inactive Kinetic Oscillation Stimulation (KOS), Active Kinetic Oscillation Stimulation (KOS)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Post-COVID ME/CFS
Repeat Immunoadsorption Post Covid ME/CFS
The evidence for an autoimmune etiology in postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is growing.
- Trial name
- NCT05629988
- Testing
- IA with TheraSorb ® column
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
ME/CFS, Fibromyalgia (FM)
Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study
Chronic fatiguing illnesses such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Fibromyalgia, and Long COVID are becoming a major global health challenge.
- Conditions
- ME/CFS, Fibromyalgia (FM), Long-COVID, Control Group
- Trial name
- NCT07874217
- Testing
- Cryotherapy
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog.
- Conditions
- ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue
- Trial name
- NCT07523113
- Testing
- Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Chronic Fatigue Syndrome
Ampligen in Chronic Fatigue Syndrome
This is an open label study of Ampligen in patients with chronic fatigue syndrome.
- Trial name
- NCT00215813
- Testing
- Poly I: Poly C12U (Rintatolimod)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- AIM ImmunoTech Inc.
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS
This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a…
- Trial name
- NCT04026425
- Testing
- Two-day cardiopulmonary exercise test
- Where
- 3 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ithaca College
Fatigue Syndrome, Chronic
Epigenetics of Post-exertional Malaise in Patients With ME/CFS
Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology.
- Trial name
- EPIME (NCT04378634)
- Testing
- Exercise, Mental Stress Test
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME), Post COVID Syndrome
Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chronic Fatigue Syndrome and Post COVID Syndrome
This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and…
- Trial name
- NCT06978582
- Testing
- Mindful and conscious movement-based exercise, Conventional exercise
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- University of Seville
Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS
Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC).
- Conditions
- Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- POTS-CFS (NCT06054958)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Long COVID, PTLDs
A Prospective Study to Evaluate the Role of T-Cell Dysfunction in Patients Who Present Symptoms Associated With Long COVID, Lyme Disease and Myalic Encephalomyelitis / Chronic Fatigue Syndrome Using the Vira Immune Fluorospot T Cell Assay
This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS.
- Conditions
- Long COVID, PTLDs, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
- Trial name
- NCT06731179
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ViraxBio Labs
Healthy Controls
Healthy Control Population for PAIS-ME/CFS: Study to Evaluate Possible Biomarkers and Methods for Examination of PAIS-ME/CFS Diagnostics in Healthy Volunteers
Using the data from the HelP study, the underlying processes of the diseases ME/CFS and PAIS are to be researched and elucidated.
- Trial name
- HelP (NCT06653712)
- Testing
- Diagnostic Test
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME)
Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS)
Significant clinical improvements of ME/CFS symptoms were observed in two patients with long-standing ME/CFS who received adjuvant chemotherapy including cyclophosphamide for breast cancer, also in one ME/CFS patient who received…
- Trial name
- CycloME (NCT02444091)
- Testing
- Cyclophosphamide
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Haukeland University Hospital