Clinical trials: MODS
Burden, Dependency, Mortality
Burden, Mortality and Supply Costs in Intensive Care Unit Patients
This study systematically observes in a pragmatic trail under real world conditions the association between strategies of therapy (maximal therapy, withhold, withdraw) and treatment success in three endpoint related initial risk…
- Conditions
- Burden, Dependency, Mortality, End-of-life Care, Intensive Care Unit
- Trial name
- PLV_Ulm (NCT04094428)
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- University of Ulm
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Sepsis, Severe Sepsis
Vitamin D Status in Patients With Severe Sepsis
Sepsis is a clinical entity that complicates infection. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome.
- Conditions
- Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
- Trial name
- ViDISS (NCT02684487)
- Testing
- vitamin D3
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Sepsis, Septic Shock
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
Sepsis and septic shock patients are considered to have a high risk of complications and death. Appropriate antimicrobial therapy plays an important role in determining outcomes in septic patients.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Carbapenem
- Trial name
- NCT03344627
- Testing
- Meropenem standard dose, Meropenem high dose
- Where
- Thailand
- Volunteers
- 76 people
- Sponsor
- Mahidol University
Multi Organ Failure, Acute Kidney Injury
Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT
Several studies point at a potential relationship between vitamin D deficiency and worse outcome in critically ill patients admitted to the intensive care unit.
- Trial name
- VitDcrrt (NCT02414386)
- Testing
- biospecimen retention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
COVID-19
TXA127 for the Treatment of Severe COVID-19
The purpose of this study is to determine if administration of angiotensin-(1-7) (TXA127) prevents acute kidney injury and deterioration into multi-organ failure in patients with severe COVID-19.
- Trial name
- NCT04401423
- Testing
- TXA127
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Covid19, Organ Failure, Multiple
DNA Damage in Critically Ill COVID-19 Patients
Critically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine…
- Conditions
- Covid19, Organ Failure, Multiple, DNA Damage
- Trial name
- NCT04772703
- Testing
- COMET ASSAY
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Hradec Kralove
Multiple Organ Failure, Sepsis
Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients
The purpose of this study is to determine the pharmacokinetic properties of two different dosage regimens of intravenous vitamin C in patients admitted to the Intensive Care Unit with life-threatening illness.
- Conditions
- Multiple Organ Failure, Sepsis, Systemic Inflammatory Response Syndrome, Trauma
- Trial name
- NCT02455180
- Testing
- Ascorbic Acid
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Respiratory Failure, Circulatory Failure
ICU Background Early Awareness for Critical deterioratiON
The study will compare ICU sub-units, those with additional support of a clinician awareness system, ICU Beacon, and those receiving the standard of care.
- Conditions
- Respiratory Failure, Circulatory Failure, Mortality, Organ Dysfunction
- Trial name
- BEACON (NCT07119411)
- Testing
- ICU Beacon
- Where
- Switzerland
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Septic Shock, Disseminated Intravascular Coagulation
Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients
Septic shock is common complication in patients with critical illnesses, with higher incidence in low and medium income countries like ours.
- Trial name
- NCT06363149
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Liver Failure, Acute on Chronic
Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC (NCT02457637)
- Testing
- Standary therapy
- Where
- 16 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Hai Li
Multiorgan Failure, Perfusion; Complications
NIRS and DO2i Correlation
This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.
- Trial name
- NCT03281707
- Testing
- NIRS, DO2i
- Volunteers
- 50 people
- Sponsor
- Centro Cardiologico Monzino
Kidney Injury, Acute
Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients
Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney…
- Trial name
- NCT01824771
- Testing
- Plasma lactate were measured
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Preventive Medicine, Multi Organ Failure
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA
A study to assess effectiveness and safety of a drug FP-1201-lyo (Recombinant Human Interferon Beta-1a) in the Prevention of Multi-Organ Failure on patients after Open Surgery for a Ruptured Abdominal Aortic Aneurysm
- Trial name
- INFORAAA (NCT03119701)
- Testing
- Interferon Beta-1A
- Where
- 9 sites in Estonia, Finland and 1 more
- Volunteers
- 40 people
- Sponsor
- Faron Pharmaceuticals Ltd
Trauma; Complications, Multiple Organ Failure
A Validation of a Genomics Based Prognostic in Severe Trauma
The purpose of this study is to learn more about how to treat patients with severe injuries related to trauma and to prevent failure of vital organs in this patient population.
- Trial name
- NCT01810328
- Testing
- Traumatized population, Healthy Volunteers
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
Multi Organ Failure
Infusion of Prostacyclin vs Placebo for 72-hours in Trauma Patients With Haemorrhagic Shock Suffering From Organ Failure
A multicenter, randomized (1:1, iloprost: placebo), placebo controlled, blinded, investigator-initiated phase 2b trial in trauma patients with haemorrhagic shock and shock induced endotheliopathy (SHINE), investigating the…
- Trial name
- SHINE-TRAUMA (NCT03903939)
- Testing
- Iloprost, Isotonic saline
- Where
- 5 sites in Denmark, Norway
- Volunteers
- 228 people
- Sponsor
- Pär Johansson
Multiple Organ Dysfunction Syndrome
Tolerance and Safety of a Duodenal Probe Monitoring the Microcirculation
For Intensive Care Units (ICU) patients, Multiple Organ Dysfunction Syndrome (MODS) is a very common complication yielding high morbidity and mortality.
- Trial name
- MC Monitor (NCT02246036)
- Testing
- APD probe
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- Advanced Perfusion Diagnostics