Clinical trials: MRI-guided Treatment
Brain Tumor
MRI-Guided Focused Ultrasound Feasibility Study for Brain Tumors
The purpose of this study is to evaluate the safety of MRI-guided focused ultrasound thermal ablation of brain tumors performed through intact human skull using the ExAblate transcranial system.
- Trial name
- NCT00147056
- Testing
- ExAblate transcranial system
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- InSightec
Stroke, Cerebrovascular Disorders
Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity
The investigators ultimate goal is to personalize brain stimulation for stroke so outcomes of the upper limb can be maximized for each individual patient.
- Conditions
- Stroke, Cerebrovascular Disorders, Nervous System Diseases, Brain Diseases
- Trial name
- NCT03020433
- Testing
- rTMS Contralesional M1, rTMS Contralesional PMC, rTMS Ipsilesional PMC
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Prostate Cancer, Adenocarcinoma of the Prostate
MRI-Guided Radiation Therapy in Treating Patients Who Have Undergone Surgery to Remove the Prostate
This is a prospective clinical trial examining the use of MRI to measure internal organ motion and any resulting changes in the target volume (shape and location) during a course of post-operative radiation therapy for prostate…
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- NCT01028885
- Testing
- radiation therapy treatment planning/simulation, intensity-modulated radiation therapy, image-guided radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Uterine Fibroids
Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids
The purpose of this study is to determine whether ablation of uterine fibroids with MR guided focused ultrasound following 3 months pre-treatment with Gonadotrophin releasing analogues will allow the effective use of this therapy…
- Trial name
- NCT00159328
- Testing
- Magnetic Resonance Guided Focused Ultrasound
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Breast Cancer
Percutaneous Removal and Margin Ablation for Breast Cancer
We hypothesize that radiofrequency ablation after single-insertion image guided vacuum assisted biopsy (IVEB) can be used to achieve negative margins in small unicentric breast cancers (≤1.5 cm).
- Trial name
- NCT00574301
- Testing
- Percutaneous Removal and Margin Ablation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Pancreas Cancer, Lung Cancer
Stereotactic Magnetic Resonance Guided Radiation Therapy
This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer.
- Conditions
- Pancreas Cancer, Lung Cancer, Renal Cancer, Adrenal Metastases
- Trial name
- NCT04115254
- Testing
- MR-guided Linac
- Where
- 2 sites in United States
- Volunteers
- 397 people
- Sponsor
- Dana-Farber Cancer Institute
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Prostate Cancer
This clinical trial studies the side effects and how well magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) works in treating patients with prostate cancer.
- Conditions
- Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8
- Trial name
- NCT07769372
- Testing
- Biopsy Procedure, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Bone Metastases, Bone Neoplasm
Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis
The PRE-FURTHER study aims to evaluate the feasibility of the combined treatment with radiotherapy and focussed ultrasound for pain palliation in patients with painful bone metastases, and to optimize the combined treatment…
- Conditions
- Bone Metastases, Bone Neoplasm, Bone Lesion, Bone Cancer
- Trial name
- PRE-FURTHER (NCT04310410)
- Testing
- combined radiotherapy and MR-HIFU
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Glioblastoma, Gliosarcoma
Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma
This pilot clinical trial studies the side effects of spectroscopic magnetic resonance imaging (MRI)-guided radiation therapy and how well it works in treating patients with newly-diagnosed glioblastoma or gliosarcoma.
- Trial name
- NCT03137888
- Testing
- Dose-Escalated Radiation Therapy, Spectroscopic Magnetic Resonance Imaging, Temozolomide
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Head and Neck Neoplasm
Dose-Escalated Hypofractionated Adaptive Radiotherapy for Head and Neck Cancer
Locoregional failure remains the principal mode of mortality in head and neck squamous cell carcinoma (HNSCC) treated with conventional chemoradiation therapy.
- Trial name
- DEHART (NCT04477759)
- Testing
- 50 Gy Radiation Therapy, 55 Gy Radiation Therapy, 60 Gy Radiation Therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical College of Wisconsin
Prostatic Neoplasms, Prostate Cancer
Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy
Background: Radiation is a common treatment for prostate cancer. It helps damage tumor cells and causes them to die. Radiation can be effective, but some tumors may be harder to treat with radiation or even with surgery.
- Trial name
- NCT01834001
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Breast Cancer, Brain Metastases
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases
The purpose of this study is to evaluate the safety of BBB disruption using the ExAblate 4000-system Type 2 in patients with Her-2 positive breast cancer metastases in the brain.
- Trial name
- BBBD (NCT03714243)
- Testing
- ExAblate BBBD
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- InSightec
Idiopathic Parkinson's Disease, Parkinson's Disease
Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease
Safety and efficacy of AADC gene transfer in participants with Parkinson's disease.
- Conditions
- Idiopathic Parkinson's Disease, Parkinson's Disease, Basal Ganglia Disease, Brain Diseases
- Trial name
- NCT03065192
- Testing
- VY-AADC01
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Neurocrine Biosciences
Squamous Cell Tumors of the Head and Neck
Chemo-Radiotherapy Boost Treatment Guided by Perfusion MRI on Hypoxic Zones in Head and Neck Cancer
To assess and localize hypoxic tumor subregions both at baseline and during the second week of radiotherapy. And to hypothesize that an intensified IMRT regimen may ensure higher local response rates compared to the standard IMRT…
- Trial name
- NCT06880289
- Testing
- Cisplatin IV on days 1, 22, 43, at a dose of 100 mg/m2
- Where
- 2 sites in Italy
- Volunteers
- 91 people
- Sponsor
- Regina Elena Cancer Institute
Breast Cancer
MRI-Guided Ultrasound Energy in Treating Patients With Stage I, Stage II, or Stage IIIA Breast Cancer
RATIONALE: Imaging procedures, such as MRI, may allow the doctor to better detect the tumor. Highly focused ultrasound energy may be able to kill tumor cells by heating the breast tumor cells without affecting the surrounding…
- Trial name
- NCT00008437
- Testing
- high-intensity focused ultrasound ablation
- Where
- 2 sites in United States, Canada
- Sponsor
- InSightec
Prostate Cancer
Targeted Cryoablation of Prostate Cancer Lesions: An Investigator-initiated Trial
This clinical trial is to provide a minimally invasive treatment option in which the targeted prostate cancer tissue is killed by cryoablation at extremely low temperatures only in the specific area of cancer "that should be…
- Trial name
- PROCRY (NCT05500846)
- Testing
- The Visual Ice Cryoablation System
- Where
- 2 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Osamu Ukimura
Breast Cancer
MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
The objective of this study is to demonstrate the feasibility of novel Magnetic Resonance Imaging (MRI)-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam…
- Trial name
- NCT06633601
- Testing
- MR-Guided Focused Ultrasound Technology, Definity Suspension for Injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Metastatic Carcinoma
Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) in One Fraction
This is a multi-site single arm feasibility study of single-fraction Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) for primary or metastatic carcinoma involving the lung, liver, adrenal gland, abdominal/pelvic lymph…
- Trial name
- SMART ONE (NCT04939246)
- Testing
- Stereotactic ablative body radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baptist Health South Florida
Treatment Resistant Depression, Visual Perceptual Weakness
Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression
Major depressive disorder (MDD) exhibit reduced visual motor perception, which affects prognosis. Metabolic substance changes and abnormal neural activity in the middle temporal visual area (MT) mediate this perceptual…
- Trial name
- NCT06044324
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University