Clinical trials: MRSA Infections
Staphylococcal Skin Infection, Abscess
Individualized vs. Household MRSA Decolonization
The purpose of this research study is to compare the effectiveness of commonly used decolonization treatments (application of mupirocin antibiotic ointment to the nose and bleach baths) when performed by individuals with a…
- Conditions
- Staphylococcal Skin Infection, Abscess, Furunculosis, Staphylococcus Aureus
- Trial name
- HOME2DS (NCT01814371)
- Testing
- 2% mupirocin ointment, Bleach Bath (dilute), Hygiene Protocol
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- Washington University School of Medicine
Bacterial Infections, Wounds
Effects of MRSA Bactericidal Gel To Promote Healing and Eliminate MRSA in cSSTI Vancogel(TM)
Based on personal experience and the literature it is reasonable expectation that Vancomycin is a viable treatment in a direct contact form to eliminate MRSA from open wounds in order to heal the wounds by conventional means.
- Trial name
- Vancogel(R) (NCT00945152)
- Testing
- Vancomycin 1.25-1.50% in a complex gel formulation trademarked Vancogel(R)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Robert S Berman MD
Staphylococcal Skin Infection
Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus
Study 0018 (NCT00107978) compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections.
- Trial name
- ATLAS2 (NCT00107978)
- Testing
- Telavancin, Vancomycin
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- Cumberland Pharmaceuticals
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community
The overall goal of this project is to elucidate the epidemiology of MRSA transmission in the community and test an intervention to prevent MRSA transmission in this setting.
- Trial name
- NCT00966446
- Testing
- Unsupervised Decolonization, Supervised Decolonization
- Where
- 4 sites in United States
- Volunteers
- 223 people
- Sponsor
- University of Pennsylvania
MRSA Bloodstream Infection, MRSA Bacteremia
Expanded Access Study of Exebacase in COVID-19 Patients With Persistent MRSA Bacteremia
This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI)…
- Conditions
- MRSA Bloodstream Infection, MRSA Bacteremia, MRSA Right-sided Endocarditis, Covid19
- Trial name
- NCT04597242
- Testing
- Exebacase
- Where
- 2 sites in United States
- Sponsor
- ContraFect
Methicillin-Resistant Staphylococcus Aureus, Cystic Fibrosis
Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)
This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy.
- Trial name
- TRI-STAR (NCT02684422)
- Testing
- Intervention N/A. Observational study
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Wound Infection
Prevention of Gastrostomy-Related Wound Infection by Vancomycin in Carriers of Methicillin-Resistant Staphylococcus Aureus.
The aim of this study is to determine whether vancomycin with cefazoline is superior to vancomycin with placebo in preventing gastrostomy-related wound infection in carriers of methicillin-resistant staphylococcus aureus (MRSA).
- Trial name
- NCT00150852
- Testing
- Vancomycin
- Where
- 3 sites in France, Switzerland
- Volunteers
- 96 people
- Sponsor
- University Hospital, Geneva
MRSA Colonization
MRSA in a Trauma Population: Does Decolonization Prevent Infection?
All trauma patients admitted to certain Intensive Care Units (ICU) will have Methicillin-resistant Staphylococcus aureus (MRSA) nasal swabs performed to determine MRSA colonization status.
- Trial name
- NCT01820455
- Testing
- Chlorhexidine, Mupirocin, Soap baths, Lubricating Jelly
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Tennessee
Blood Stream Infections, MRSA Infections
Testing Spread and Implementation of Novel Methicillin Resistant Staphylococcal Aureus (MRSA)-Reducing Practices
The purpose of this study is to implement strategies for improved efficiency and waste reduction ("Toyota Lean") and positive deviance, a social behavioral change process, utilizing frontline healthcare personnel to reduce…
- Trial name
- NCT01255943
- Testing
- healthcare staff processes for infection prevention
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- MaineHealth
Periprosthetic Joint Infection
Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial
The gold standard for treating prosthetic joint infection (PJI) is two-stage exchange arthroplasty. This includes the first stage of debridement and removal of the artificial joint, and the second stage of reimplantation of the…
- Trial name
- NCT06189885
- Testing
- Cefazolin with Daptomycin, Cefazolin with vancomycin
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Chang Gung Memorial Hospital
Infection
Trimethoprim-Sulfamethoxazole or Doxycycline for Skin and Soft Tissue Infections
Background: In many communities, skin and soft tissue infections (SSTI) with MRSA have become more prevalent than infections with β-lactam susceptible bacteria.
- Trial name
- NCT00428818
- Testing
- trimethoprim-sulfamethoxazole or doxycycline
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Burns, Wounds
Kerlix Gauze Study in a Burn Trauma Unit and Its Effect on Healthcare Associated Infections in Burn Patients
The purpose of this study is to determine whether Kerlix AMD gauze will decrease the incidence of healthcare associated infections in burn patients.
- Trial name
- NCT00656708
- Testing
- Kerlix AMD gauze
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Lucy A Wibbenmeyer
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
Gram-Positive Bacterial Infections, Staphylococcus Infections
Study Evaluating Tigecycline in Selected Serious Infections Caused by Vancomycin-Resistant Enterococcus (VRE) or Methicillin-Resistant Staphylococcus Aureus (MRSA)
To evaluate the safety and efficacy of tigecycline in the treatment of selected serious infections caused by VRE. The primary efficacy endpoint will be the clinical response for all subjects.
- Conditions
- Gram-Positive Bacterial Infections, Staphylococcus Infections, Vancomycin Resistance, Methicillin Resistance
- Trial name
- NCT00079976
- Testing
- Tigecycline
- Volunteers
- 174 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Guide Rapid Antibiotic Treatment for Serious Infections
This research will test a new ultra-rapid technology (called ID/AST Accelerate system) that uses a digital microscope to identify bacteria based on their growth patterns.
- Conditions
- INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- NCT02796716
- Testing
- Testing on new technology called Accelerate ID/AST system
- Where
- United States
- Volunteers
- 2,102 people
- Sponsor
- Denver Health and Hospital Authority
Staphylococcus Aureus
Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial
This study involves the use of investigational vaccines. A vaccine is a medicine that causes the body to make antibodies. Antibodies help destroy foreign substances that enter the body.
- Trial name
- NCT01011335
- Testing
- Monovalent rAT, Monovalent rLukS-PV, Bivalent rLukS-PV / rAT
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Pneumonia, Ventilator-Associated
Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus
Ventilator-associated pneumonia (VAP) is a commonplace complication of intensive care patients ventilated for longer than 48 hours.
- Trial name
- NCT00572559
- Testing
- Vancomycin, Linezolid
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 149 people
- Sponsor
- Pfizer
Pneumonia, Bacterial
Rapid De-escalation of Anti-MRSA Therapy Guided by S. Aureus Nares Screening in Case of Pneumonia
The current IDSA/ATS guidelines recommend Linezolid and Vancomycin for MRSA coverage in hospitalized patients with pneumonia, which is common clinical practice in Italy.
- Trial name
- SNAP (NCT06238297)
- Testing
- MRSA nasal swab based de-escalation
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- University of Bari Aldo Moro
Skin Diseases, Infectious
Effective Antibiotic Treatment of MRSA
To evaluate the effective duration (in days) to clinical improvement of outpatient antibiotic regimens in the treatment of superficial abscesses caused by MRSA in patients that present to the emergency department.
- Trial name
- NCT00388310
- Testing
- Culture
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Prospective Evaluation of a Vancomycin Nomogram With a Continuous Infusion of Vancomycin for Surgical ICU Patients
Vancomycin is an essential antimicrobial which is frequently used in the ICU for suspected methicillin-resistant Staphylococcus aureus (MRSA) infection.
- Trial name
- CIV (NCT01786161)
- Testing
- Vancomycin continuous infusion, Vancomycin intermittent dosing interval
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital